Radiosynthesis and biological evaluation of 166Ho labeled methoxylated porphyrins as possible therapeutic agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07

AUTHORS

Nasim Vahidfar, Amir R. Jalilian, Yousef Fazaeli, Ali Bahrami-Samani, Davood Beiki, Ali Khalaj

ABSTRACT

166Ho labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin, and 5,10,15,20-tetrakis(3,4,5-trimethoxyphenyl) porphyrin ([166Ho]–TDMPP and [166Ho]–TTMPP respectively) were prepared with acceptable radiochemical purity and specific activities. Stability and partition coefficient of the complexes were determined in the final formulations and biodistribution studies in mouse demonstrated high accumulation of [166Ho]–TDMPP in the lung and liver and less excretion through the kidney. while [166Ho]–TTMPP was mostly excreted into intestines and kidneys while lungs were a minor accumulation site. In contrast to other reported radiolanthanide labeled porphyrins these two complexes showed less liver accumulation. Further investigation of their potential therapeutic properties is of interest. More... »

PAGES

269-276

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-014-3113-2

DOI

http://dx.doi.org/10.1007/s10967-014-3113-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008480895


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