Preparation and preliminary evaluation of [67Ga]-tetra phenyl porphyrin complexes as possible imaging agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04

AUTHORS

Yousef Fazaeli, Amir R. Jalilian, Mostafa M. Amini, Ali Rahiminejad-kisomi, Saeed Rajabifar, Fatemeh Bolourinovin, Sedigheh Moradkhani

ABSTRACT

[67Ga]labeled tetraphenyl porphyrin ([67Ga]-TPP) was prepared using freshly prepared [67Ga]GaCl3 and tetraphenyl porphyrin (TPPH2) for 30–60 min at 25 °C (radiochemical purity: >97 ± 1% ITLC, >98 ± 0.5% HPLC, specific activity: 13–14 GBq/mmol). Stability of the complex was checked in final formulation and human serum for 24 h. The partition coefficient was calculated for the compound (log P 1.89). The biodistribution of the labeled compound in vital organs of wild-type rats was studied using scarification studies and SPECT imaging up to 24 h. A detailed comparative pharmacokinetic study performed for 67Ga cation and [67Ga]-TPP. The complex is mostly washed out from the circulation through kidneys and can be an interesting tumor imaging/targeting agent due to low liver uptake and rapid excretion through the urinary tract. More... »

PAGES

17-24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-010-0962-1

DOI

http://dx.doi.org/10.1007/s10967-010-0962-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041204248


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