Preparation and evaluation of [201Tl](III)-DTPA complex for cell labeling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

A. R. Jalilian, Y. Yari-Kamrani, M. Kamali-Dehghan, S. Rajabifar

ABSTRACT

Due to interesting physical properties and wide availability of 201Tl as a SPECT radionuclide, the incorporation of this nuclide into DTPA for cell labeling was targeted. Thallium-201 (T1/2 = 3.04 d) in Tl+ form was converted to Tl3+ cation in the presence of O3/6M HCl and di-isopropyl ether, controlled by RTLC/gel electrophoresis methods. The final evaporated activity reacted with cDTPA in normal saline to yield [201Tl](III)DTPA at room temperature after 0.5 hour, followed by solid phase extraction purification using C18 Sep-Pak column (radiochemical yield >95%). Radiochemical purity of more than 99% was obtained using RTLC with specific activity of about 260 GBq/mmol. The stability of the tracer was checked in the final product in the presence of human serum at 37 °C up to 3 days. The partition coefficient was also measured. The labeled compound was used in red blood cell (RBC) labeling. The cell uptake ratio was determined at 4, 25 and 37 °C up to 3 hours. More... »

PAGES

109-114

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-007-6938-0

DOI

http://dx.doi.org/10.1007/s10967-007-6938-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028950697


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