Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07

AUTHORS

A. R. Jalilian, M. Sabet, P. Rowshanfarzad, M. Kamali-dehghan, M. Akhlaghi, M. Mirzaii

ABSTRACT

Copper-61 produced via the natZn(p,x)61Cu nuclear reaction was used for the preparation of [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) (4) using a house-made ATSM ligand. After a proton irradiation of an electroplated zinc layer by 22 MeV protons at 180 mA for 3.2 hours, 61Cu was recovered by two-step chromatography using a cation and an anion exchange column. About 222 GBq (6.00 Ci) of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of better than 99%. Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The [61Cu]ATSM production was optimized for reaction conditions (buffer concentration and temperature) with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and a specific activity of about 246 Ci/mmol. The produced [61Cu]ATSM is a PET radiotracer for hypoxia imaging with an intermediate half life and a satisfactory quality, suitable for future PET studies. More... »

PAGES

147-154

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-006-0244-0

DOI

http://dx.doi.org/10.1007/s10967-006-0244-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034204237


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Analytical Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jalilian", 
        "givenName": "A. R.", 
        "id": "sg:person.0630401370.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630401370.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "SSDL and Health Physics Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabet", 
        "givenName": "M.", 
        "id": "sg:person.01016625775.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016625775.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rowshanfarzad", 
        "givenName": "P.", 
        "id": "sg:person.0750512575.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750512575.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamali-dehghan", 
        "givenName": "M.", 
        "id": "sg:person.0737144356.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737144356.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akhlaghi", 
        "givenName": "M.", 
        "id": "sg:person.0762526103.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762526103.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy Organization of Iran", 
          "id": "https://www.grid.ac/institutes/grid.459846.2", 
          "name": [
            "Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mirzaii", 
        "givenName": "M.", 
        "id": "sg:person.0654664743.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654664743.23"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2006-07", 
    "datePublishedReg": "2006-07-01", 
    "description": "Copper-61 produced via the natZn(p,x)61Cu nuclear reaction was used for the preparation of [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) (4) using a house-made ATSM ligand. After a proton irradiation of an electroplated zinc layer by 22 MeV protons at 180 mA for 3.2 hours, 61Cu was recovered by two-step chromatography using a cation and an anion exchange column. About 222 GBq (6.00 Ci) of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of better than 99%. Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The [61Cu]ATSM production was optimized for reaction conditions (buffer concentration and temperature) with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and a specific activity of about 246 Ci/mmol. The produced [61Cu]ATSM is a PET radiotracer for hypoxia imaging with an intermediate half life and a satisfactory quality, suitable for future PET studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10967-006-0244-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094634", 
        "issn": [
          "0236-5731", 
          "1588-2780"
        ], 
        "name": "Journal of Radioanalytical and Nuclear Chemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "269"
      }
    ], 
    "name": "Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies", 
    "pagination": "147-154", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a2efe43181c59a9e406d1e38c59c51ace08b6258551b7c7bae104f239ae26d1a"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10967-006-0244-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034204237"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10967-006-0244-0", 
      "https://app.dimensions.ai/details/publication/pub.1034204237"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10967-006-0244-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10967-006-0244-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10967-006-0244-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10967-006-0244-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10967-006-0244-0'


 

This table displays all metadata directly associated to this object as RDF triples.

97 TRIPLES      20 PREDICATES      27 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10967-006-0244-0 schema:about anzsrc-for:03
2 anzsrc-for:0301
3 schema:author Nfc33841214f84092aab9ba9f499ac5c4
4 schema:datePublished 2006-07
5 schema:datePublishedReg 2006-07-01
6 schema:description Copper-61 produced via the natZn(p,x)61Cu nuclear reaction was used for the preparation of [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) (4) using a house-made ATSM ligand. After a proton irradiation of an electroplated zinc layer by 22 MeV protons at 180 mA for 3.2 hours, 61Cu was recovered by two-step chromatography using a cation and an anion exchange column. About 222 GBq (6.00 Ci) of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of better than 99%. Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The [61Cu]ATSM production was optimized for reaction conditions (buffer concentration and temperature) with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and a specific activity of about 246 Ci/mmol. The produced [61Cu]ATSM is a PET radiotracer for hypoxia imaging with an intermediate half life and a satisfactory quality, suitable for future PET studies.
7 schema:genre research_article
8 schema:inLanguage en
9 schema:isAccessibleForFree false
10 schema:isPartOf N9cc2d5b371c349059f9540eacc44c37c
11 Nea1941b65d4343918d16be95abdf27a4
12 sg:journal.1094634
13 schema:name Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies
14 schema:pagination 147-154
15 schema:productId N16a460280ccb4eb8bddbcb64642840c7
16 N97bb3717c9684fe7a50b12985dca662f
17 Nd2e999a2268f465791f17a37f663438f
18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034204237
19 https://doi.org/10.1007/s10967-006-0244-0
20 schema:sdDatePublished 2019-04-10T14:10
21 schema:sdLicense https://scigraph.springernature.com/explorer/license/
22 schema:sdPublisher Nc0097b9029ea440db3f05b3ceeddaab4
23 schema:url http://link.springer.com/10.1007%2Fs10967-006-0244-0
24 sgo:license sg:explorer/license/
25 sgo:sdDataset articles
26 rdf:type schema:ScholarlyArticle
27 N089453e8517445a99473f060149dcffd rdf:first sg:person.0750512575.25
28 rdf:rest N2affed2b5e4441b9b373d60375f3fb65
29 N16a460280ccb4eb8bddbcb64642840c7 schema:name readcube_id
30 schema:value a2efe43181c59a9e406d1e38c59c51ace08b6258551b7c7bae104f239ae26d1a
31 rdf:type schema:PropertyValue
32 N1fb1c1710aa149a3995aa3fb36296ed1 rdf:first sg:person.01016625775.03
33 rdf:rest N089453e8517445a99473f060149dcffd
34 N2affed2b5e4441b9b373d60375f3fb65 rdf:first sg:person.0737144356.18
35 rdf:rest N910f66db83714ac292ee84a890317b86
36 N910f66db83714ac292ee84a890317b86 rdf:first sg:person.0762526103.16
37 rdf:rest Na8c759abaf3f4dbf8cb4a2c584a7cf3f
38 N97bb3717c9684fe7a50b12985dca662f schema:name dimensions_id
39 schema:value pub.1034204237
40 rdf:type schema:PropertyValue
41 N9cc2d5b371c349059f9540eacc44c37c schema:issueNumber 1
42 rdf:type schema:PublicationIssue
43 Na8c759abaf3f4dbf8cb4a2c584a7cf3f rdf:first sg:person.0654664743.23
44 rdf:rest rdf:nil
45 Nc0097b9029ea440db3f05b3ceeddaab4 schema:name Springer Nature - SN SciGraph project
46 rdf:type schema:Organization
47 Nd2e999a2268f465791f17a37f663438f schema:name doi
48 schema:value 10.1007/s10967-006-0244-0
49 rdf:type schema:PropertyValue
50 Nea1941b65d4343918d16be95abdf27a4 schema:volumeNumber 269
51 rdf:type schema:PublicationVolume
52 Nfc33841214f84092aab9ba9f499ac5c4 rdf:first sg:person.0630401370.00
53 rdf:rest N1fb1c1710aa149a3995aa3fb36296ed1
54 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
55 schema:name Chemical Sciences
56 rdf:type schema:DefinedTerm
57 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
58 schema:name Analytical Chemistry
59 rdf:type schema:DefinedTerm
60 sg:journal.1094634 schema:issn 0236-5731
61 1588-2780
62 schema:name Journal of Radioanalytical and Nuclear Chemistry
63 rdf:type schema:Periodical
64 sg:person.01016625775.03 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
65 schema:familyName Sabet
66 schema:givenName M.
67 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016625775.03
68 rdf:type schema:Person
69 sg:person.0630401370.00 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
70 schema:familyName Jalilian
71 schema:givenName A. R.
72 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630401370.00
73 rdf:type schema:Person
74 sg:person.0654664743.23 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
75 schema:familyName Mirzaii
76 schema:givenName M.
77 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654664743.23
78 rdf:type schema:Person
79 sg:person.0737144356.18 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
80 schema:familyName Kamali-dehghan
81 schema:givenName M.
82 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737144356.18
83 rdf:type schema:Person
84 sg:person.0750512575.25 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
85 schema:familyName Rowshanfarzad
86 schema:givenName P.
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750512575.25
88 rdf:type schema:Person
89 sg:person.0762526103.16 schema:affiliation https://www.grid.ac/institutes/grid.459846.2
90 schema:familyName Akhlaghi
91 schema:givenName M.
92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762526103.16
93 rdf:type schema:Person
94 https://www.grid.ac/institutes/grid.459846.2 schema:alternateName Atomic Energy Organization of Iran
95 schema:name Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran
96 SSDL and Health Physics Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran, P.O. Box 31485-498, Karaj, Iran
97 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...