Kit for instant 99mTc labeling of the antimicrobial peptide ubiquicidin 29-41 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-11

AUTHORS

G. Ferro-Flores, C. Arteaga de Murphy, P. Palomares-Rodríguez, L. Meléndez-Alafort, M. Pedraza-López

ABSTRACT

The ubiquicidin 29-41 fragment (UBI) is a cationic antimicrobial peptide. The aim of this study was to develop an instant kit formulation for the preparation of 99mTc-UBI 29-41 in high radiochemical yield and to evaluate its use as an infection imaging agent in humans. The components were selected to produce a direct 99mTc labeling, presumably to the amine groups of Lys and Arg7. 99mTc-UBI 29-41 obtained from the lyophilized kit showed radiochemical purity of >97% with an average target/non-target ratio of 2.3±0.6 in positive infection sites at 2 hours. Kits were stable at 4 °C for over 6 months. More... »

PAGES

307-311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-005-0908-1

DOI

http://dx.doi.org/10.1007/s10967-005-0908-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038155745


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