Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-01

AUTHORS

Alexander W. Jackson

ABSTRACT

The incorporation of biologically active targeting ligands into polymeric materials is a key challenge in drug delivery and bioimaging. Reported here is the synthesis of diblock copolymers end-functionalized with the Somatostatin analog Octreotide. This methodology employs a novel Octreotide functional reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agent, which is used to mediate the polymerization of N-isopropylacrylamide and subsequent chain-extension with N,N-dimethylacrylamide. More... »

PAGES

64

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10965-017-1220-9

DOI

http://dx.doi.org/10.1007/s10965-017-1220-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084028362


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