Structural Characterizations of the Fas Receptor and the Fas-Associated Protein with Death Domain Interactions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Urmi Roy

ABSTRACT

The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's activity. The Fas-FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems. The interactions responsible for this cell-death process are governed by the binding process of the Fas ligand to the Fas, followed by the caspase cascade activation. Using a computational approach, the present communication explores certain essential structural aspects of the Fas-FADD death domains and their interfacial interactions. More... »

PAGES

51-60

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10930-015-9646-6

DOI

http://dx.doi.org/10.1007/s10930-015-9646-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034236905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26743763


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