Structural Evaluation and Analyses of Tumor Differentiation Factor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10

AUTHORS

Urmi Roy, Alisa G. Woods, Izabela Sokolowska, Costel C. Darie

ABSTRACT

Tumor differentiation factor (TDF) is a protein produced by the pituitary and secreted into the blood stream. The mechanism of its action has still not been elucidated, although the associated protein receptor was identified. Furthermore, the TDF protein does not have any homology with other known proteins, and the crystal structure of TDF also is not available at this time. To gain some insight into the structure of this rather underexplored protein, we have performed a molecular dynamics simulation of a model TDF structure. The structural stability of this protein is evaluated as a function of time. The time dependent structural changes of four cysteine residues present in this structure also are explored. More... »

PAGES

512-518

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10930-013-9510-5

DOI

http://dx.doi.org/10.1007/s10930-013-9510-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035021618

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24037223


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