Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading α-Mangostin View Full Text


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Article Info

DATE

2021-07-05

AUTHORS

Thi Hien Nguyen, Thuy Chinh Nguyen, Thi Minh Tu Nguyen, Dinh Hoa Hoang, Do Mai Trang Tran, Dinh Thang Tran, Phuong Thai Hoang, Van Tan Le, Thi Kim Ngan Tran, Hoang Thai

ABSTRACT

This study attempted to develop carrageenan/chitosan based microparticles loading α-mangostin which was extracted from Vietnamese mangosteen skin. The carrageenan/chitosan/α-mangostin microparticles were prepared by ionic gelation method by mixing chitosan, carrageenan with α-mangostin and subsequently cross-linking the mixtures with sodium tripolyphosphate crosslinking agent. The content of α-mangostin in microparticles was changed to evaluate the effect of α-mangostin content on physical, morphological properties, particles size and bioactivities of the carrageenan/chitosan/α-mangostin microparticles. The obtained results showed that carrageenan, chitosan was interacted together and with α-mangostin. The presence of polymers matrix improved the release ability of α-mangostin into ethanol/pH buffer solutions. The carrageenan/chitosan/α-mangostin microparticles have antibacterial (gram ( +) strains) and antioxidant activities. The results suggested that combination of chitosan and carrageenan in the microparticles can enhance the control release of α-mangostin into solutions as well as keep the bioactivities and reduce the vero cell toxicity of α-mangostin. More... »

PAGES

1-13

References to SciGraph publications

  • 2008-09-26. Iota-Carrageenan is a potent inhibitor of rhinovirus infection in VIROLOGY JOURNAL
  • 2019-12-20. Cyclodextrin-based nanoparticles encapsulating α-mangostin and their drug release behavior: potential carriers of α-mangostin for cancer therapy in POLYMER JOURNAL
  • 2018-07-23. In Vitro and In Silico Studies of Chitin and Chitosan Based Nanocarriers for Curcumin and Insulin Delivery in JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • 2018-03-13. Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo in JOURNAL OF APPLIED PHYCOLOGY
  • 2015-02-27. Synthesis of α − mangostin-D-glucoside in supercritical carbon dioxide media in JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
  • 2021-02-23. Development of Multi-Cellular Gel Droplets Using κ-Carrageenan Composited Alginate for Controlled Release of Hydrophobic Components in JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • 2020-04-07. Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery in JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • 2012-12-18. Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug in JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • 2020-10-22. In Vitro and In Vivo Evaluation of Oral Disintegrating Nanofiber and Thin-Film Contains Hyperbranched Chitosan/Donepezil for Active Drug Delivery in JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • 2017-11-24. Nanocarrier-mediated delivery of α-mangostin for non-surgical castration of male animals in SCIENTIFIC REPORTS
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    http://scigraph.springernature.com/pub.10.1007/s10924-021-02230-2

    DOI

    http://dx.doi.org/10.1007/s10924-021-02230-2

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