Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04-22

AUTHORS

Kazuhiro Nakayama, Takayoshi Shotake, Osamu Takeneka, Takafumi Ishida

ABSTRACT

Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have determined and compared nucleotide sequences of protein coding region of ASIP in 18 macaque species and have identified 16 different sequences of the ASIP. Macaca nemestrina, which showed yellow agouti hairs, shared an identical amino acid sequence of ASIP with several non-agouti species. No sequence changes were found in functionally important sites of ASIP in the macaques showing non-agouti dark hair color. These results indicated that the variation in the protein coding region of ASIP did not explain the non-agouti dark coat color in the macaques. Upstream regulatory regions of ASIP and other genes participating in pigmentation system remain to be investigated for the hair color variation in the macaques. More... »

PAGES

211-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10914-010-9137-7

DOI

http://dx.doi.org/10.1007/s10914-010-9137-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010789643


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakayama", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01057752627.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057752627.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shotake", 
        "givenName": "Takayoshi", 
        "id": "sg:person.01055732151.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055732151.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeneka", 
        "givenName": "Osamu", 
        "id": "sg:person.0641256305.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641256305.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "Takafumi", 
        "id": "sg:person.015576331772.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00335-005-0104-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026908377", 
          "https://doi.org/10.1007/s00335-005-0104-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-006-0056-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010406405", 
          "https://doi.org/10.1007/s00335-006-0056-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0397-311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029845575", 
          "https://doi.org/10.1038/ng0397-311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-004-2377-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012918764", 
          "https://doi.org/10.1007/s00335-004-2377-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02380850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038074634", 
          "https://doi.org/10.1007/bf02380850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642657", 
          "https://doi.org/10.1038/nprot.2009.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003350020010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024335092", 
          "https://doi.org/10.1007/s003350020010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003359900939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053071779", 
          "https://doi.org/10.1007/s003359900939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003350020017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037386099", 
          "https://doi.org/10.1007/s003350020017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-004-1251-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007556063", 
          "https://doi.org/10.1007/s00439-004-1251-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-04-22", 
    "datePublishedReg": "2010-04-22", 
    "description": "Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have determined and compared nucleotide sequences of protein coding region of ASIP in 18 macaque species and have identified 16 different sequences of the ASIP. Macaca nemestrina, which showed yellow agouti hairs, shared an identical amino acid sequence of ASIP with several non-agouti species. No sequence changes were found in functionally important sites of ASIP in the macaques showing non-agouti dark hair color. These results indicated that the variation in the protein coding region of ASIP did not explain the non-agouti dark coat color in the macaques. Upstream regulatory regions of ASIP and other genes participating in pigmentation system remain to be investigated for the hair color variation in the macaques.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10914-010-9137-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1104248", 
        "issn": [
          "1064-7554", 
          "1573-7055"
        ], 
        "name": "Journal of Mammalian Evolution", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "region of ASIP", 
      "protein gene", 
      "hair color variation", 
      "Agouti Signaling Protein Gene", 
      "amino acid sequence", 
      "upstream regulatory region", 
      "identical amino acid sequences", 
      "darker hair color", 
      "pigmentation phenotype", 
      "regulatory region", 
      "nucleotide sequence", 
      "acid sequence", 
      "sequence variation", 
      "dark coat color", 
      "coding regions", 
      "pigmentation system", 
      "sequence changes", 
      "coat color", 
      "genes", 
      "macaque species", 
      "phenotype", 
      "color variation", 
      "species", 
      "protein", 
      "sequence", 
      "laboratory mice", 
      "ASIP", 
      "important site", 
      "different sequences", 
      "mammals", 
      "hair color", 
      "agouti", 
      "mutations", 
      "region", 
      "variation", 
      "hair", 
      "agouti hair", 
      "black hair", 
      "macaques", 
      "primates", 
      "Macaca nemestrina", 
      "sites", 
      "mice", 
      "nemestrina", 
      "color", 
      "changes", 
      "results", 
      "system", 
      "issues", 
      "common pigmentation phenotype", 
      "non-agouti black hairs", 
      "agouti/non-agouti phenotypes", 
      "non-agouti phenotypes", 
      "yellow agouti hairs", 
      "non-agouti species", 
      "non-agouti dark hair color", 
      "non-agouti dark coat color", 
      "Signaling Protein Gene"
    ], 
    "name": "Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques", 
    "pagination": "211-214", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010789643"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10914-010-9137-7"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10914-010-9137-7", 
      "https://app.dimensions.ai/details/publication/pub.1010789643"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_527.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10914-010-9137-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10914-010-9137-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10914-010-9137-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10914-010-9137-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10914-010-9137-7'


 

This table displays all metadata directly associated to this object as RDF triples.

180 TRIPLES      22 PREDICATES      93 URIs      75 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10914-010-9137-7 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N2c9059f66cd144b29927b98543bede59
4 schema:citation sg:pub.10.1007/bf02380850
5 sg:pub.10.1007/s00335-004-2377-1
6 sg:pub.10.1007/s00335-005-0104-1
7 sg:pub.10.1007/s00335-006-0056-0
8 sg:pub.10.1007/s003350020010
9 sg:pub.10.1007/s003350020017
10 sg:pub.10.1007/s003359900939
11 sg:pub.10.1007/s00439-004-1251-2
12 sg:pub.10.1038/ng0397-311
13 sg:pub.10.1038/nprot.2009.86
14 schema:datePublished 2010-04-22
15 schema:datePublishedReg 2010-04-22
16 schema:description Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have determined and compared nucleotide sequences of protein coding region of ASIP in 18 macaque species and have identified 16 different sequences of the ASIP. Macaca nemestrina, which showed yellow agouti hairs, shared an identical amino acid sequence of ASIP with several non-agouti species. No sequence changes were found in functionally important sites of ASIP in the macaques showing non-agouti dark hair color. These results indicated that the variation in the protein coding region of ASIP did not explain the non-agouti dark coat color in the macaques. Upstream regulatory regions of ASIP and other genes participating in pigmentation system remain to be investigated for the hair color variation in the macaques.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N0206c0c17e234151aada9abe92061a52
21 Nd7ce6ac9f4be4790a1cade566c0d512a
22 sg:journal.1104248
23 schema:keywords ASIP
24 Agouti Signaling Protein Gene
25 Macaca nemestrina
26 Signaling Protein Gene
27 acid sequence
28 agouti
29 agouti hair
30 agouti/non-agouti phenotypes
31 amino acid sequence
32 black hair
33 changes
34 coat color
35 coding regions
36 color
37 color variation
38 common pigmentation phenotype
39 dark coat color
40 darker hair color
41 different sequences
42 genes
43 hair
44 hair color
45 hair color variation
46 identical amino acid sequences
47 important site
48 issues
49 laboratory mice
50 macaque species
51 macaques
52 mammals
53 mice
54 mutations
55 nemestrina
56 non-agouti black hairs
57 non-agouti dark coat color
58 non-agouti dark hair color
59 non-agouti phenotypes
60 non-agouti species
61 nucleotide sequence
62 phenotype
63 pigmentation phenotype
64 pigmentation system
65 primates
66 protein
67 protein gene
68 region
69 region of ASIP
70 regulatory region
71 results
72 sequence
73 sequence changes
74 sequence variation
75 sites
76 species
77 system
78 upstream regulatory region
79 variation
80 yellow agouti hairs
81 schema:name Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques
82 schema:pagination 211-214
83 schema:productId Nbcc93c164ff7411d9714b3ff031e2a72
84 Nf96c1e75ddaf4579bd69ae5e4f85ea88
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010789643
86 https://doi.org/10.1007/s10914-010-9137-7
87 schema:sdDatePublished 2022-01-01T18:23
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Ne7b606db8566496e9d1192f764a27a46
90 schema:url https://doi.org/10.1007/s10914-010-9137-7
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0206c0c17e234151aada9abe92061a52 schema:issueNumber 3
95 rdf:type schema:PublicationIssue
96 N2c9059f66cd144b29927b98543bede59 rdf:first sg:person.01057752627.97
97 rdf:rest Nfbdd1ea19ac942e4b364cb49d435b22a
98 Nbcc93c164ff7411d9714b3ff031e2a72 schema:name doi
99 schema:value 10.1007/s10914-010-9137-7
100 rdf:type schema:PropertyValue
101 Ncaa8ee07b611495fad00e8647bfbf51a rdf:first sg:person.0641256305.85
102 rdf:rest Nd52ad05e8d2c43a0b1769c87fb76237f
103 Nd52ad05e8d2c43a0b1769c87fb76237f rdf:first sg:person.015576331772.42
104 rdf:rest rdf:nil
105 Nd7ce6ac9f4be4790a1cade566c0d512a schema:volumeNumber 17
106 rdf:type schema:PublicationVolume
107 Ne7b606db8566496e9d1192f764a27a46 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 Nf96c1e75ddaf4579bd69ae5e4f85ea88 schema:name dimensions_id
110 schema:value pub.1010789643
111 rdf:type schema:PropertyValue
112 Nfbdd1ea19ac942e4b364cb49d435b22a rdf:first sg:person.01055732151.02
113 rdf:rest Ncaa8ee07b611495fad00e8647bfbf51a
114 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
115 schema:name Biological Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
118 schema:name Genetics
119 rdf:type schema:DefinedTerm
120 sg:journal.1104248 schema:issn 1064-7554
121 1573-7055
122 schema:name Journal of Mammalian Evolution
123 schema:publisher Springer Nature
124 rdf:type schema:Periodical
125 sg:person.01055732151.02 schema:affiliation grid-institutes:grid.258799.8
126 schema:familyName Shotake
127 schema:givenName Takayoshi
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055732151.02
129 rdf:type schema:Person
130 sg:person.01057752627.97 schema:affiliation grid-institutes:grid.26999.3d
131 schema:familyName Nakayama
132 schema:givenName Kazuhiro
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057752627.97
134 rdf:type schema:Person
135 sg:person.015576331772.42 schema:affiliation grid-institutes:grid.26999.3d
136 schema:familyName Ishida
137 schema:givenName Takafumi
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42
139 rdf:type schema:Person
140 sg:person.0641256305.85 schema:affiliation grid-institutes:grid.258799.8
141 schema:familyName Takeneka
142 schema:givenName Osamu
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641256305.85
144 rdf:type schema:Person
145 sg:pub.10.1007/bf02380850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038074634
146 https://doi.org/10.1007/bf02380850
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s00335-004-2377-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012918764
149 https://doi.org/10.1007/s00335-004-2377-1
150 rdf:type schema:CreativeWork
151 sg:pub.10.1007/s00335-005-0104-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026908377
152 https://doi.org/10.1007/s00335-005-0104-1
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s00335-006-0056-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010406405
155 https://doi.org/10.1007/s00335-006-0056-0
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/s003350020010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024335092
158 https://doi.org/10.1007/s003350020010
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s003350020017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037386099
161 https://doi.org/10.1007/s003350020017
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s003359900939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053071779
164 https://doi.org/10.1007/s003359900939
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s00439-004-1251-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007556063
167 https://doi.org/10.1007/s00439-004-1251-2
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/ng0397-311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029845575
170 https://doi.org/10.1038/ng0397-311
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nprot.2009.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642657
173 https://doi.org/10.1038/nprot.2009.86
174 rdf:type schema:CreativeWork
175 grid-institutes:grid.258799.8 schema:alternateName Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan
176 schema:name Primate Research Institute, Kyoto University, 484-8506, Inuyama, Aichi, Japan
177 rdf:type schema:Organization
178 grid-institutes:grid.26999.3d schema:alternateName Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan
179 schema:name Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 113-0033, Tokyo, Japan
180 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...