When to Consider Risk-Reducing Mastectomy in BRCA1/BRCA2 Mutation Carriers with Advanced Stage Ovarian Cancer: a Case Study Illustrating the Genetic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Beverley Speight, Marc Tischkowitz

ABSTRACT

Germline mutations in BRCA1/BRCA2 significantly increase the risk of breast and ovarian cancer in women. This case report describes a BRCA1 germline mutation identified in a woman with stage IV epithelial ovarian cancer and the provision of genetic counseling about BRCA1-associated breast cancer risk in the three years following diagnosis. The report centers on the patient's enquiry about risk-reducing breast surgery. We focus on the challenges for health professionals and patients in understanding and balancing the risks and benefits of major prophylactic surgery in the context of a potentially life-limiting cancer diagnosis. Breast cancer risk management in BRCA1/BRCA2 carriers with advanced ovarian cancer is an under-explored area of genetic counseling research. This article includes a case report, a review of the relevant literature and considers some implications for practice. More... »

PAGES

1173-1178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10897-017-0136-1

DOI

http://dx.doi.org/10.1007/s10897-017-0136-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091053975

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28780755


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