Relationship between Vitamin D Levels and Bone Tissue in Adolescents with and without Down Syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Ángel Matute-Llorente, Alejandro González-Agüero, Luis A. Moreno-Aznar, Germán Vicente-Rodríguez, José A. Casajús

ABSTRACT

Vitamin D (vitD) deficiency is a worldwide problem. Therefore, the main aims of this study were to compare 25-hydroxivitamin D levels (25(OH)D) in adolescents with and without Down syndrome (DS) and to study the relationship between 25(OH)D and bone. Eleven adolescents with DS (6 females) aged 15.5 ± 2.8 years and sixteen healthy controls (non-DS) (6 females) aged 14.3 ± 2.2 years were evaluated by bone imaging techniques. Blood samples were collected to determine vitD levels. Independent t-tests and analyses of covariance controlling for age, height, sex, sexual maturation, calcium intake and body mass index were performed to evaluate differences in 25(OH)D levels between groups. Pearson’s correlation test and multiple linear regression analyses were performed to examine the association between 25(OH)D and bone mass. Adolescents with DS had lower 25(OH)D (22.8 ± 8.0 vs. 36.0 ± 6.5 ng/ml) than non-DS (d = 1.81; p < 0.05). Only 18% of participants with DS reached the recommended level of 30 ng/ml of 25(OH)D. No significant group interactions were found for any bone variable (all p > 0.05) but linear regression analyses suggested that 25(OH)D influenced positively femoral neck bone mineral density (β = 0.477, p = 0.038) and content at the 4% of the length of the tibia (β = 0.453, p = 0.008) in the non-DS and cortical volumetric bone mineral density at the 38% (β = 0.841, p = 0.034) in the DS. Adolescents with DS had lower levels of 25(OH)D and higher prevalence of vitD deficiency compared with non-DS. Associations between 25(OH)D and bone parameters were not observed for adolescents with DS but medium and positive correlations were observed in the non-DS group. More... »

PAGES

611-624

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10882-017-9545-1

DOI

http://dx.doi.org/10.1007/s10882-017-9545-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084760264


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248 https://www.grid.ac/institutes/grid.484042.e schema:alternateName Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
249 schema:name Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain
250 Departamento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud y del Deporte, Instituto Agroalimentario de Aragón-IA2-(Universidad de Zaragoza-CITA), C/ Pedro Cerbuna 12, Grupo GENUD, 50009, Zaragoza, Spain
251 GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, C/ Pedro Cerbuna, 12 50009, Zaragoza, Spain
252 Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain
253 rdf:type schema:Organization
 




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