Clinical Course in a Patient With Neutrophil-Specific Granule Deficiency and Rapid Detection of Neutrophil Granules as a Screening Test View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Tomonari Shigemura, Takashi Yamazaki, Masaaki Shiohara, Norimoto Kobayashi, Kuniaki Naganuma, Kenich Koike, Kazunaga Agematsu

ABSTRACT

PURPOSE: Neutrophil-specific granule deficiency (SGD) is a rare, congenital disorder characterized by atypical neutrophil structure and function that results in frequent and severe bacterial infections. However, the clinical course of patients with SGD have not been described in detail because of the scarcity of the disease. We present the clinical course of an adult patient with SGD and propose a method for making an early diagnosis of SGD. PATIENT AND METHODS: A32-year-old Japanese woman with SGD had a small impetigo lesion on her face and experienced the rapid spread of a facial abscess to a pulmonary abscess via the blood stream. We also analyzed the expression of neutrophil granule proteins in our patient compared with a healthy control by flow cytometry. RESULTS: We confirmed defects of several neutrophil granule proteins in our patient by flow cytometry. CONCLUSION: Severe bacterial infections sometimes occur and spread rapidly in SGD. Detection of neutrophil granules by flow cytometry is useful for a rapid diagnosis and a screening of SGD. More... »

PAGES

780-783

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-014-0082-8

DOI

http://dx.doi.org/10.1007/s10875-014-0082-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035395745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25081842


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