Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Alejandro Vazquez-Tello, Rabih Halwani, Qutayba Hamid, Saleh Al-Muhsen

ABSTRACT

PURPOSE: Most asthmatic patients have well controlled symptoms with regular treatment, but some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to respond; these patients may present Th-17 cell infiltration and associated cytokines (IL-17A and -F) in the airways, sputum and peripheral blood. Because glucocorticoid receptor-beta (GR-beta) is associated with corticosteroid resistance, we investigated whether Th-17 associated cytokines induce steroid insensitivity in PBMCs via GR-beta up-regulation. METHODS: GR-alpha, GR-beta, GILZ and IL-6 expression were analyzed in PBMCs stimulated with IL-2/IL-4, IL-17A/IL-17F and IL-23 cytokines by quantitative RT-PCR. Dexamethasone-inhibition of PHA-induced proliferation and Dexamethasone-induced apoptosis were determined by either (3)H-thymidine or CFSE-labelled cells and by Annexin-V staining and flow cytometry. RESULTS: IL-17 and IL-23 cytokines significantly increased GR-beta expression. IL-2/IL-4 significantly decreased GR-alpha expression without affecting GR-beta. IL17, IL-23 and IL2 + 4 stimulations significantly hampered Dexamethasone-inhibition of proliferation (Dex EC(50) for: IL-17A + F = 251 nM; IL-23 = 435 nM; IL2 + 4 = 950 nM; Medium = 90 nM). IL2 + 4 and IL17A + F but not IL-23, significantly hampered Dexamethasone-induced apoptosis (1400 and 320 nM Dex, respectively). Dexamethasone's trans-activation of GILZ and trans-repression of NF-kB-driven IL-6 expression were both inhibited by IL2 + 4; IL17 + IL23 antagonized Dex trans-repression in PBMC from asthmatics. CONCLUSIONS: GR-beta up-regulation by IL-17/IL-23 cytokines is associated with induced steroid insensitivity in PBMCs, observed as diminished Dexamethasone's effects on cell proliferation, apoptosis and gene regulation. Steroid resistance induced by IL-2/IL-4 was associated with decreased GR-alpha expression. This study supports the possibility that Th-17 lymphocytes and associated cytokines play a role in the mechanism of steroid hypo-responsiveness in severe asthmatics. More... »

PAGES

466-478

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-012-9828-3

DOI

http://dx.doi.org/10.1007/s10875-012-9828-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044672971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23160983


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asthma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-17", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-23", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes, Mononuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Glucocorticoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "King Saud University", 
          "id": "https://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Asthma Research Chair and Prince Naif Center for Immunology Research, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vazquez-Tello", 
        "givenName": "Alejandro", 
        "id": "sg:person.0673611031.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673611031.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Saud University", 
          "id": "https://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Asthma Research Chair and Prince Naif Center for Immunology Research, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halwani", 
        "givenName": "Rabih", 
        "id": "sg:person.0653703642.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653703642.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Meakins-Christie Laboratories and Respiratory Division, Department of Medicine, McGill University, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamid", 
        "givenName": "Qutayba", 
        "id": "sg:person.016215742657.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215742657.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Saud University", 
          "id": "https://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Asthma Research Chair and Prince Naif Center for Immunology Research, King Saud University, Riyadh, Saudi Arabia", 
            "Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Muhsen", 
        "givenName": "Saleh", 
        "id": "sg:person.0634613272.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634613272.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1513/pats.200402-014ms", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000695088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11882-004-0060-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002298789", 
          "https://doi.org/10.1007/s11882-004-0060-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003171550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003171550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003616467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004440626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005663571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.329.7472.966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007084949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0704063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007318007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.08-0440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007702415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2007.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009163583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2006.10.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011322362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200500266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011712046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012648496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012648496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.212365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015528690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.181.6.4089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017849618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.105.019679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019726416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-10-248245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021208825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201001-0015oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021811902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.12.4319-4330.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022120094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2004.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022430264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0098-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023416255", 
          "https://doi.org/10.1007/s00018-009-0098-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0098-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023416255", 
          "https://doi.org/10.1007/s00018-009-0098-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0098-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023416255", 
          "https://doi.org/10.1007/s00018-009-0098-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/144.5.1016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024649692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2011.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025337139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4110/in.2010.10.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027598848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4110/in.2010.10.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027598848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-3038.1998.tb00293.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029241064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200308-1143oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029685071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2005.02846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029794219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2005.02846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029794219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1398-9995.2002.02164.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029945723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1000690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030424706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.162.1.9911032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033402656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2010.03544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2010.03544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037139398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2010-0369oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037232561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2003.12.322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037365470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.159.5.9804131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037542138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037983153", 
          "https://doi.org/10.1038/sj.cdd.4400724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037983153", 
          "https://doi.org/10.1038/sj.cdd.4400724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3858/emm.2009.41.5.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038113137", 
          "https://doi.org/10.3858/emm.2009.41.5.033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3858/emm.2009.41.5.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038113137", 
          "https://doi.org/10.3858/emm.2009.41.5.033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02801323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038511468", 
          "https://doi.org/10.1007/bf02801323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02801323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038511468", 
          "https://doi.org/10.1007/bf02801323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2011.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039130540", 
          "https://doi.org/10.1038/tpj.2011.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2007.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039463723", 
          "https://doi.org/10.1038/cr.2007.35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/rr31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040111563", 
          "https://doi.org/10.1186/rr31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.122.6_suppl.278s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045269931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.122.6_suppl.278s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045269931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0407008101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046750075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mai.2002.122635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046847173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00363.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051346930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.16.9550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052040489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000146344.49689.bb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052865970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mai.2000.106486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053544768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.9.1567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.9.6986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.84.11.4149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064300560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2004-0206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077584324", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.181.4.2799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077686006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080481060", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082781152", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082794514", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082800593", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082991401", 
          "https://doi.org/10.1007/bf03401643"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-02", 
    "datePublishedReg": "2013-02-01", 
    "description": "PURPOSE: Most asthmatic patients have well controlled symptoms with regular treatment, but some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to respond; these patients may present Th-17 cell infiltration and associated cytokines (IL-17A and -F) in the airways, sputum and peripheral blood. Because glucocorticoid receptor-beta (GR-beta) is associated with corticosteroid resistance, we investigated whether Th-17 associated cytokines induce steroid insensitivity in PBMCs via GR-beta up-regulation.\nMETHODS: GR-alpha, GR-beta, GILZ and IL-6 expression were analyzed in PBMCs stimulated with IL-2/IL-4, IL-17A/IL-17F and IL-23 cytokines by quantitative RT-PCR. Dexamethasone-inhibition of PHA-induced proliferation and Dexamethasone-induced apoptosis were determined by either (3)H-thymidine or CFSE-labelled cells and by Annexin-V staining and flow cytometry.\nRESULTS: IL-17 and IL-23 cytokines significantly increased GR-beta expression. IL-2/IL-4 significantly decreased GR-alpha expression without affecting GR-beta. IL17, IL-23 and IL2\u2009+\u20094 stimulations significantly hampered Dexamethasone-inhibition of proliferation (Dex EC(50) for: IL-17A\u2009+\u2009F\u2009=\u2009251 nM; IL-23\u2009=\u2009435 nM; IL2\u2009+\u20094\u2009=\u2009950 nM; Medium\u2009=\u200990 nM). IL2\u2009+\u20094 and IL17A\u2009+\u2009F but not IL-23, significantly hampered Dexamethasone-induced apoptosis (1400 and 320 nM Dex, respectively). Dexamethasone's trans-activation of GILZ and trans-repression of NF-kB-driven IL-6 expression were both inhibited by IL2\u2009+\u20094; IL17\u2009+\u2009IL23 antagonized Dex trans-repression in PBMC from asthmatics.\nCONCLUSIONS: GR-beta up-regulation by IL-17/IL-23 cytokines is associated with induced steroid insensitivity in PBMCs, observed as diminished Dexamethasone's effects on cell proliferation, apoptosis and gene regulation. Steroid resistance induced by IL-2/IL-4 was associated with decreased GR-alpha expression. This study supports the possibility that Th-17 lymphocytes and associated cytokines play a role in the mechanism of steroid hypo-responsiveness in severe asthmatics.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10875-012-9828-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092207", 
        "issn": [
          "0271-9142", 
          "1573-2592"
        ], 
        "name": "Journal of Clinical Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells", 
    "pagination": "466-478", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d4cb6ab5ee968af65ae9bdc1f34f9595e4ea8ee8b94b10b5a396f2d7dbb93669"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23160983"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8102137"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10875-012-9828-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044672971"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10875-012-9828-3", 
      "https://app.dimensions.ai/details/publication/pub.1044672971"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54298_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10875-012-9828-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10875-012-9828-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10875-012-9828-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10875-012-9828-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10875-012-9828-3'


 

This table displays all metadata directly associated to this object as RDF triples.

343 TRIPLES      21 PREDICATES      105 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10875-012-9828-3 schema:about N0d048a97f0374eb4bc733412cbe4fcbe
2 N124f7cebd1334cfd8e547eb5b9367bfd
3 N1668cd680b164b9aaefb74a7d5d5394d
4 N17b53f41efc3499a8846b269bb9f995a
5 N21ba2b40f0824f92b7d2715f594fb5f5
6 N3dc0f6a44da84154a617e00c3f18a275
7 N3e13c94a5ad845c9b77f5b808a0614f7
8 N47b0627132f3409f847cd541905ce8d4
9 N4b496b01e51b4e03a3e519fa0ba2baf4
10 N8c43c7be141f49c186cea9a0fd450bc7
11 N9eb110c274e247fea0908ed2038185cf
12 Na3d2bc186e074821b6f119a09f92f5c9
13 Naa9d6cfbf5e64913974e9bbe7200bbce
14 Naee1d3a1f004486d853d51b506dcd4dd
15 Nca9375c5db804b928bddf42647684ad2
16 Nd7be66fbeb0c489a89cfc8c812a7ab87
17 Ne8cc5202beb94ad082f1da3c767037a0
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N2277ddff7f784b9e890a410380aa601c
21 schema:citation sg:pub.10.1007/bf02801323
22 sg:pub.10.1007/bf03401643
23 sg:pub.10.1007/s00018-009-0098-z
24 sg:pub.10.1007/s11882-004-0060-y
25 sg:pub.10.1038/cr.2007.35
26 sg:pub.10.1038/sj.cdd.4400724
27 sg:pub.10.1038/tpj.2011.46
28 sg:pub.10.1186/rr31
29 sg:pub.10.3858/emm.2009.41.5.033
30 https://app.dimensions.ai/details/publication/pub.1077584324
31 https://app.dimensions.ai/details/publication/pub.1080481060
32 https://app.dimensions.ai/details/publication/pub.1082781152
33 https://app.dimensions.ai/details/publication/pub.1082794514
34 https://app.dimensions.ai/details/publication/pub.1082800593
35 https://doi.org/10.1002/eji.200838908
36 https://doi.org/10.1002/pmic.200500266
37 https://doi.org/10.1006/bbrc.1998.9980
38 https://doi.org/10.1016/j.clim.2011.07.003
39 https://doi.org/10.1016/j.jaci.2003.12.322
40 https://doi.org/10.1016/j.jaci.2004.11.014
41 https://doi.org/10.1016/j.jaci.2006.10.035
42 https://doi.org/10.1016/j.jaci.2007.09.010
43 https://doi.org/10.1016/j.jaci.2009.02.024
44 https://doi.org/10.1034/j.1398-9995.2002.02164.x
45 https://doi.org/10.1038/sj.bjp.0704063
46 https://doi.org/10.1053/rmed.2003.1507
47 https://doi.org/10.1067/mai.2000.106486
48 https://doi.org/10.1067/mai.2002.122635
49 https://doi.org/10.1073/pnas.0407008101
50 https://doi.org/10.1074/jbc.271.16.9550
51 https://doi.org/10.1074/jbc.m110.212365
52 https://doi.org/10.1084/jem.186.9.1567
53 https://doi.org/10.1111/j.1365-2222.2010.03544.x
54 https://doi.org/10.1111/j.1365-2249.2005.02846.x
55 https://doi.org/10.1111/j.1399-3038.1998.tb00293.x
56 https://doi.org/10.1124/mol.105.019679
57 https://doi.org/10.1128/mcb.23.12.4319-4330.2003
58 https://doi.org/10.1136/bmj.329.7472.966
59 https://doi.org/10.1152/ajpcell.00363.2001
60 https://doi.org/10.1158/0008-5472.can-05-1130
61 https://doi.org/10.1161/01.cir.0000146344.49689.bb
62 https://doi.org/10.1164/ajrccm.159.5.9804131
63 https://doi.org/10.1164/ajrccm.162.1.9911032
64 https://doi.org/10.1164/ajrccm/144.5.1016
65 https://doi.org/10.1164/rccm.200308-1143oc
66 https://doi.org/10.1164/rccm.201001-0015oc
67 https://doi.org/10.1165/rcmb.2010-0369oc
68 https://doi.org/10.1172/jci116963
69 https://doi.org/10.1182/blood-2009-10-248245
70 https://doi.org/10.1210/endo.140.9.6986
71 https://doi.org/10.1210/jc.84.11.4149
72 https://doi.org/10.1210/me.2004-0206
73 https://doi.org/10.1378/chest.08-0440
74 https://doi.org/10.1378/chest.122.6_suppl.278s
75 https://doi.org/10.1513/pats.200402-014ms
76 https://doi.org/10.4049/jimmunol.1000690
77 https://doi.org/10.4049/jimmunol.181.4.2799
78 https://doi.org/10.4049/jimmunol.181.6.4089
79 https://doi.org/10.4110/in.2010.10.1.1
80 schema:datePublished 2013-02
81 schema:datePublishedReg 2013-02-01
82 schema:description PURPOSE: Most asthmatic patients have well controlled symptoms with regular treatment, but some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to respond; these patients may present Th-17 cell infiltration and associated cytokines (IL-17A and -F) in the airways, sputum and peripheral blood. Because glucocorticoid receptor-beta (GR-beta) is associated with corticosteroid resistance, we investigated whether Th-17 associated cytokines induce steroid insensitivity in PBMCs via GR-beta up-regulation. METHODS: GR-alpha, GR-beta, GILZ and IL-6 expression were analyzed in PBMCs stimulated with IL-2/IL-4, IL-17A/IL-17F and IL-23 cytokines by quantitative RT-PCR. Dexamethasone-inhibition of PHA-induced proliferation and Dexamethasone-induced apoptosis were determined by either (3)H-thymidine or CFSE-labelled cells and by Annexin-V staining and flow cytometry. RESULTS: IL-17 and IL-23 cytokines significantly increased GR-beta expression. IL-2/IL-4 significantly decreased GR-alpha expression without affecting GR-beta. IL17, IL-23 and IL2 + 4 stimulations significantly hampered Dexamethasone-inhibition of proliferation (Dex EC(50) for: IL-17A + F = 251 nM; IL-23 = 435 nM; IL2 + 4 = 950 nM; Medium = 90 nM). IL2 + 4 and IL17A + F but not IL-23, significantly hampered Dexamethasone-induced apoptosis (1400 and 320 nM Dex, respectively). Dexamethasone's trans-activation of GILZ and trans-repression of NF-kB-driven IL-6 expression were both inhibited by IL2 + 4; IL17 + IL23 antagonized Dex trans-repression in PBMC from asthmatics. CONCLUSIONS: GR-beta up-regulation by IL-17/IL-23 cytokines is associated with induced steroid insensitivity in PBMCs, observed as diminished Dexamethasone's effects on cell proliferation, apoptosis and gene regulation. Steroid resistance induced by IL-2/IL-4 was associated with decreased GR-alpha expression. This study supports the possibility that Th-17 lymphocytes and associated cytokines play a role in the mechanism of steroid hypo-responsiveness in severe asthmatics.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree false
86 schema:isPartOf Na0c51d14a9464a2f8b82566a62c3994f
87 Nda6113f2e8fe4353bf7846bb15d66bdf
88 sg:journal.1092207
89 schema:name Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells
90 schema:pagination 466-478
91 schema:productId N1ae6885896914ae5b15158e9b61b9616
92 N251d58b286124d218f6fe714c5b99c8b
93 N488758c90dc34e6dbe58a636af1de435
94 Nd86f38952fdf454fb3c6507ce61e96e2
95 Nf40ef23bcbdc409cba65b47c463d4836
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044672971
97 https://doi.org/10.1007/s10875-012-9828-3
98 schema:sdDatePublished 2019-04-11T10:15
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher Nfe7734765bc24fa8840caec84cffb3c8
101 schema:url https://link.springer.com/10.1007%2Fs10875-012-9828-3
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0d048a97f0374eb4bc733412cbe4fcbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Receptors, Glucocorticoid
107 rdf:type schema:DefinedTerm
108 N124f7cebd1334cfd8e547eb5b9367bfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Interleukin-23
110 rdf:type schema:DefinedTerm
111 N1668cd680b164b9aaefb74a7d5d5394d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Asthma
113 rdf:type schema:DefinedTerm
114 N17b53f41efc3499a8846b269bb9f995a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N1ae6885896914ae5b15158e9b61b9616 schema:name readcube_id
118 schema:value d4cb6ab5ee968af65ae9bdc1f34f9595e4ea8ee8b94b10b5a396f2d7dbb93669
119 rdf:type schema:PropertyValue
120 N21ba2b40f0824f92b7d2715f594fb5f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N2277ddff7f784b9e890a410380aa601c rdf:first sg:person.0673611031.40
124 rdf:rest N35f9a736c0f5464da6e6f00832ea7146
125 N251d58b286124d218f6fe714c5b99c8b schema:name doi
126 schema:value 10.1007/s10875-012-9828-3
127 rdf:type schema:PropertyValue
128 N2dc0a042548e40ac86757e4b854130e7 rdf:first sg:person.016215742657.56
129 rdf:rest N3e8e5e16419846afa6c0905c64e5b250
130 N35f9a736c0f5464da6e6f00832ea7146 rdf:first sg:person.0653703642.75
131 rdf:rest N2dc0a042548e40ac86757e4b854130e7
132 N3dc0f6a44da84154a617e00c3f18a275 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 N3e13c94a5ad845c9b77f5b808a0614f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Apoptosis
137 rdf:type schema:DefinedTerm
138 N3e8e5e16419846afa6c0905c64e5b250 rdf:first sg:person.0634613272.80
139 rdf:rest rdf:nil
140 N47b0627132f3409f847cd541905ce8d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 N488758c90dc34e6dbe58a636af1de435 schema:name pubmed_id
144 schema:value 23160983
145 rdf:type schema:PropertyValue
146 N4b496b01e51b4e03a3e519fa0ba2baf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Up-Regulation
148 rdf:type schema:DefinedTerm
149 N8c43c7be141f49c186cea9a0fd450bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 N9eb110c274e247fea0908ed2038185cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Leukocytes, Mononuclear
154 rdf:type schema:DefinedTerm
155 Na0c51d14a9464a2f8b82566a62c3994f schema:issueNumber 2
156 rdf:type schema:PublicationIssue
157 Na3d2bc186e074821b6f119a09f92f5c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Interleukin-17
159 rdf:type schema:DefinedTerm
160 Naa9d6cfbf5e64913974e9bbe7200bbce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Drug Resistance
162 rdf:type schema:DefinedTerm
163 Naee1d3a1f004486d853d51b506dcd4dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cell Proliferation
165 rdf:type schema:DefinedTerm
166 Nca9375c5db804b928bddf42647684ad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Dexamethasone
168 rdf:type schema:DefinedTerm
169 Nd7be66fbeb0c489a89cfc8c812a7ab87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Interleukin-6
171 rdf:type schema:DefinedTerm
172 Nd86f38952fdf454fb3c6507ce61e96e2 schema:name dimensions_id
173 schema:value pub.1044672971
174 rdf:type schema:PropertyValue
175 Nda6113f2e8fe4353bf7846bb15d66bdf schema:volumeNumber 33
176 rdf:type schema:PublicationVolume
177 Ne8cc5202beb94ad082f1da3c767037a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Gene Expression Regulation
179 rdf:type schema:DefinedTerm
180 Nf40ef23bcbdc409cba65b47c463d4836 schema:name nlm_unique_id
181 schema:value 8102137
182 rdf:type schema:PropertyValue
183 Nfe7734765bc24fa8840caec84cffb3c8 schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
189 schema:name Clinical Sciences
190 rdf:type schema:DefinedTerm
191 sg:journal.1092207 schema:issn 0271-9142
192 1573-2592
193 schema:name Journal of Clinical Immunology
194 rdf:type schema:Periodical
195 sg:person.016215742657.56 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
196 schema:familyName Hamid
197 schema:givenName Qutayba
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215742657.56
199 rdf:type schema:Person
200 sg:person.0634613272.80 schema:affiliation https://www.grid.ac/institutes/grid.56302.32
201 schema:familyName Al-Muhsen
202 schema:givenName Saleh
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634613272.80
204 rdf:type schema:Person
205 sg:person.0653703642.75 schema:affiliation https://www.grid.ac/institutes/grid.56302.32
206 schema:familyName Halwani
207 schema:givenName Rabih
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653703642.75
209 rdf:type schema:Person
210 sg:person.0673611031.40 schema:affiliation https://www.grid.ac/institutes/grid.56302.32
211 schema:familyName Vazquez-Tello
212 schema:givenName Alejandro
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673611031.40
214 rdf:type schema:Person
215 sg:pub.10.1007/bf02801323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038511468
216 https://doi.org/10.1007/bf02801323
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/bf03401643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082991401
219 https://doi.org/10.1007/bf03401643
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s00018-009-0098-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023416255
222 https://doi.org/10.1007/s00018-009-0098-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s11882-004-0060-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1002298789
225 https://doi.org/10.1007/s11882-004-0060-y
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/cr.2007.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039463723
228 https://doi.org/10.1038/cr.2007.35
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/sj.cdd.4400724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037983153
231 https://doi.org/10.1038/sj.cdd.4400724
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/tpj.2011.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039130540
234 https://doi.org/10.1038/tpj.2011.46
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/rr31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040111563
237 https://doi.org/10.1186/rr31
238 rdf:type schema:CreativeWork
239 sg:pub.10.3858/emm.2009.41.5.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038113137
240 https://doi.org/10.3858/emm.2009.41.5.033
241 rdf:type schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1077584324 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1080481060 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1082781152 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1082794514 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082800593 schema:CreativeWork
247 https://doi.org/10.1002/eji.200838908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003171550
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/pmic.200500266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011712046
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1006/bbrc.1998.9980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003616467
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.clim.2011.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025337139
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.jaci.2003.12.322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037365470
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.jaci.2004.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022430264
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.jaci.2006.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011322362
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.jaci.2007.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009163583
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.jaci.2009.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037139398
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1034/j.1398-9995.2002.02164.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029945723
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1038/sj.bjp.0704063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007318007
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1053/rmed.2003.1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012648496
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1067/mai.2000.106486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053544768
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1067/mai.2002.122635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046847173
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1073/pnas.0407008101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046750075
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1074/jbc.271.16.9550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052040489
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1074/jbc.m110.212365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015528690
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1084/jem.186.9.1567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438636
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1365-2222.2010.03544.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035604465
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1111/j.1365-2249.2005.02846.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029794219
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1111/j.1399-3038.1998.tb00293.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029241064
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1124/mol.105.019679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019726416
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1128/mcb.23.12.4319-4330.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022120094
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1136/bmj.329.7472.966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007084949
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/ajpcell.00363.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051346930
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1158/0008-5472.can-05-1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004440626
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1161/01.cir.0000146344.49689.bb schema:sameAs https://app.dimensions.ai/details/publication/pub.1052865970
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1164/ajrccm.159.5.9804131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037542138
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1164/ajrccm.162.1.9911032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033402656
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1164/ajrccm/144.5.1016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024649692
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1164/rccm.200308-1143oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1029685071
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1164/rccm.201001-0015oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1021811902
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1165/rcmb.2010-0369oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1037232561
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1172/jci116963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005663571
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1182/blood-2009-10-248245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021208825
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1210/endo.140.9.6986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283314
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1210/jc.84.11.4149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064300560
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1210/me.2004-0206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327279
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1378/chest.08-0440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007702415
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1378/chest.122.6_suppl.278s schema:sameAs https://app.dimensions.ai/details/publication/pub.1045269931
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1513/pats.200402-014ms schema:sameAs https://app.dimensions.ai/details/publication/pub.1000695088
328 rdf:type schema:CreativeWork
329 https://doi.org/10.4049/jimmunol.1000690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030424706
330 rdf:type schema:CreativeWork
331 https://doi.org/10.4049/jimmunol.181.4.2799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077686006
332 rdf:type schema:CreativeWork
333 https://doi.org/10.4049/jimmunol.181.6.4089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017849618
334 rdf:type schema:CreativeWork
335 https://doi.org/10.4110/in.2010.10.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027598848
336 rdf:type schema:CreativeWork
337 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
338 schema:name Meakins-Christie Laboratories and Respiratory Division, Department of Medicine, McGill University, Montreal, QC, Canada
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.56302.32 schema:alternateName King Saud University
341 schema:name Asthma Research Chair and Prince Naif Center for Immunology Research, King Saud University, Riyadh, Saudi Arabia
342 Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
343 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...