Changes of Treg-Associated Molecules on CD4+CD25+Treg Cells in Myasthenia Gravis and Effects of Immunosuppressants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03-31

AUTHORS

Wen-Hua Xu, Ai-Mei Zhang, Ming-Shan Ren, Xu-Dong Zhang, Fang Wang, Xiu-Cai Xu, Qing Li, Jian Wang, Bang-Sheng Din, Yuan-Bo Wu, Gui-Hai Chen

ABSTRACT

ObjectiveMyasthenia gravis (MG) is a CD4+ T cell-dependent autoimmune disease, and close attention has been paid to the role of CD4+CD25+Treg cells (Tregs). Previous results regarding Tregs in MG patients have been conflicting. The discrepancy was partly ascribed to selecting different Treg-associated molecules in defining Tregs. Therefore, we considered it necessary to find a reliable index for assessing the immunologic state in MG patients and explore the effect of IS on them.MethodsWe adopted flow cytometric techniques to measure the numbers and frequencies of Tregs in peripheral blood taken from 57 patients and 91 age-matched healthy donors, and we also analyzed FOXP3 mean fluorescence intensity on Tregs.ResultsThe number and frequency of Tregs in peripheral blood of MG patients significantly decreased, together with down-regulation of FOXP3 expression. There was dynamic change of Treg cell level and the inverse relationship with clinical symptom, suggesting that the immunologic disorder in MG patients was related to peripheral Tregs population. Meanwhile, CD4+CD25+FOXP3+Helios+T cells might be activated Tregs, rather than nTregs. Moreover, the number and frequency of CD4+CD25+FOXP3+Helios+T cells significantly decreased in MG patients, indicating that the reduction of the activated Tregs population might be a critical contributor to the pathogenesis of MG.ConclusionsThe significant reduction of the peripheral Tregs population in MG patients might be responsible for the immunologic disorders in MG patients. IS such as GC took its effect possible by increasing the population size, and the underlying mechanism should be further investigated. More... »

PAGES

975-983

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-012-9685-0

DOI

http://dx.doi.org/10.1007/s10875-012-9685-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046567576

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22467037


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