Coronary Artery Abnormalities in Hyper-IgE Syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Alexandra F. Freeman, Elizabeth Mannino Avila, Pamela A. Shaw, Joie Davis, Amy P. Hsu, Pamela Welch, Jatin R. Matta, Colleen Hadigan, Roderic I. Pettigrew, Steven M. Holland, Ahmed M. Gharib

ABSTRACT

OBJECTIVE: Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency caused by autosomal dominant STAT3 mutations resulting in recurrent infections and connective tissue abnormalities. Coronary artery abnormalities have been reported infrequently. We aimed to determine the frequency and characteristics of coronary artery abnormalities. DESIGN: STAT3-mutated HIES patients (n=38), ranging in age from 8 to 57 years, underwent coronary artery imaging by computed tomography or magnetic resonance imaging. Images were evaluated for tortuosity, dilation, and aneurysm. Charts were reviewed for cardiac risk factors. To allow blinded image interpretation, an age- and gender-matched non-HIES group was also evaluated (n=33). RESULTS: Coronary artery tortuosity or dilation occurred in 70% of HIES patients, with aneurysms present in 37%, incidences much higher than in the literature and in our non-HIES group, in which 21% had tortuosity or dilation and 3% had aneurysms. Hypertension was more common in the HIES group than in the general population and was associated with vessel abnormalities. Atherosclerosis was uncommon and mild. CONCLUSIONS: Coronary artery aneurysms and tortuosity are common in HIES, despite a paucity of atherosclerosis, suggesting that STAT3 plays an integral role in human vascular remodeling and atherosclerosis. More... »

PAGES

338-345

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-011-9515-9

DOI

http://dx.doi.org/10.1007/s10875-011-9515-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010576558

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21494893


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