Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rγnull (NSG) Mice Conditioned by Busulfan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10-28

AUTHORS

Bongkum Choi, Eunyoung Chun, Miyoung Kim, Seong-Tae Kim, Keejung Yoon, Ki-Young Lee, Sung Joo Kim

ABSTRACT

BackgroundBusulfan treatment as a chemotherapeutic agent has been considered an alternative approach in xenograft model because it offers a simple, convenient, effective, and less toxic conditioning regimen.Objective and methodsTo investigate busulfan effects on the reconstitution of human immune cells and the generation of immune response to foreign antigens, we generated humanized NOD/SCID/IL-2Rγnull (NSG) mice conditioned either busulfan or total body irradiation (TBI) with hCD34+ CB cells.ResultsBusulfan resulted in a high survival rate and effective reconstitution of human immune cells including B, T, macrophage, and dendritic cells in humanized NSG mice, compared to that of TBI. Moreover, the humanized NSG mice conditioned busulfan showed effective B cell development and thereby the high production of human antibody against immunized antigen.ConclusionHumanized mice conditioned by busulfan provide a powerful and versatile tool for studying the entire process of human B-lymphocyte development and for producing specific human antibodies More... »

PAGES

253-264

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-010-9478-2

DOI

http://dx.doi.org/10.1007/s10875-010-9478-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023553631

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20981478


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