CD3ζ Expression and T Cell Proliferation are Inhibited by TGF-β1 and IL-10 in Cervical Cancer Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03-04

AUTHORS

Cinthya E. Díaz-Benítez, Karla R. Navarro-Fuentes, Jacqueline A. Flores-Sosa, Janet Juárez-Díaz, Felipe J. Uribe-Salas, Edgar Román-Basaure, Ludwig E. González-Mena, Patricia Alonso de Ruíz, Guillermina López-Estrada, Alfredo Lagunas-Martínez, Victor H. Bermúdez-Morales, Juan M. Alcocer-González, Jesús Martínez-Barnetche, Rogelio Hernández-Pando, Yvonne Rosenstein, José Moreno, Vicente Madrid-Marina

ABSTRACT

IntroductionCervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC).Results and DiscussionT cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-γ were observed in women with CC. Moreover, infiltrating cells showed marginal responses. We also found that CD3ζ mRNA expression, whose protein is required for T cell activation, correlated with a decreased proliferation in advanced stages of the disease.ConclusionExperiments with T cells from healthy donors in the presence TGF-β1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during CC progression. More... »

PAGES

532-544

Journal

TITLE

Journal of Clinical Immunology

ISSUE

4

VOLUME

29

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-009-9279-7

DOI

http://dx.doi.org/10.1007/s10875-009-9279-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015830380

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19259799


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