Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-04-01

AUTHORS

Seung-Hyun Kim, Hyun-Hwan Jeong, Bo-Young Cho, MyoungKi Kim, Hyun-Young Lee, Jungseob Lee, Kyubum Wee, Hae-Sim Park

ABSTRACT

IntroductionAspirin-intolerant asthma (AIA), a major clinical presentation of aspirin hypersensitivity, affects 10% of adult asthmatics. The genetic risk factors involved in the susceptibility to AIA have recently been investigated, but multilocus single-nucleotide polymorphisms (SNPs) associated with this susceptibility has not been evaluated.MethodsWe examined 246 asthmatic patients: 94 having aspirin intolerance and 152 having aspirin tolerance. We selected 23 SNPs of 13 candidate genes and genotyped each SNP using a primer extension method. Multilocus genetic interactions were examined using multifactor dimensionality reduction (MDR) to test all multilocus SNP combinations to identify a useful SNP set for predicting the AIA phenotype.ResultsWe identified the best model using the MDR method, which consisted of a four-locus gene–gene interaction with 65.16% balanced accuracy and a cross-validation consistency of 70% in predicting AIA disease risk among asthmatic patients. This model included four SNPs such as B2ADR 46A>G, CCR3–520T>G, CysLTR1–634C>T, and FCER1B–109T>C.DiscussionThese results suggest that a multilocus SNP acts in combination to influence the susceptibility to aspirin intolerance in asthmatics and could be a useful genetic marker for the diagnosis of AIA. More... »

PAGES

336-342

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-008-9190-7

DOI

http://dx.doi.org/10.1007/s10875-008-9190-7

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https://app.dimensions.ai/details/publication/pub.1043854554

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18379861


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