Programmed Cell Death of Peripheral Blood B Cells Determined by Laser Scanning Cytometry in Sjögren’s Syndrome with a Special Emphasis ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

PETER SZODORAY, STIG JELLESTAD, PHILIP ALEX, TONG ZHOU, PATRICK C. WILSON, MICHAEL CENTOLA, JOHAN G. BRUN, ROLAND JONSSON

ABSTRACT

Functionally impaired B cells play an important role in the pathogenesis of Sjögren’s syndrome (SS). The aim of the study was to investigate the apoptosis susceptibility of peripheral blood B cells from patients with SS and the impact of B cell activating factor (BAFF) on the apoptosis capability of these cells in correlation with IgG production. Peripheral blood B cells were isolated and stained for apoptosis markers (Bax, Bcl-2) and members of the TNF-R superfamily, CD95 and CD40. The apoptosis frequency of cells bearing these markers were assessed. Also, the apoptosis capability of cultured B-lymphocytes was investigated in medium alone, with anti-CD95 or with soluble BAFF. Quantitative ELISA was performed to detect plasma levels of sBAFF. Furthermore, the level of circulating B-cell cytokines was measured. BAFF levels were compared between patients with normal and elevated IgG levels. In SS, Bcl-2 positive B cell counts were significantly higher then in controls, also in this population the apoptosis frequency was reduced. Apoptosis within Bax+ and CD40+ B cells were significantly decreased in patients. BAFF induced a significant antiapoptotic effect in SS; also this effect was clearly evident in B cells from SS with hypergammaglobulinaemia. Plasma BAFF levels were significantly higher in SS, mostly in patients with hypergammaglobulinaemia. Plasma B-cell cytokines were raised in SS. In Sjögren’s syndrome B cells, a general antiapoptotic tendency might lead to prolonged B-cell survival driven at least partly by elevated levels of BAFF and supposedly by B-cell cytokines. Also, the exaggerated BAFF stimulation might lead to excessive immunoglobulin production. The B-cell apoptosis defects, the increased BAFF levels—correlating with hypergammaglobulinaemia—together with the raised B-cell cytokine levels indicates the disturbed B-cell biology in the disease. More... »

PAGES

600-611

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10875-004-6240-7

DOI

http://dx.doi.org/10.1007/s10875-004-6240-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035697068

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15622444


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74 cytokine levels
75 cytokines
76 cytometry
77 death
78 defects
79 disease
80 effect
81 elevated IgG levels
82 elevated levels
83 emphasis
84 factors
85 frequency
86 hypergammaglobulinaemia
87 immunoglobulin production
88 impact
89 important role
90 laser scanning cytometry
91 levels
92 lymphocytes
93 markers
94 medium
95 members
96 pathogenesis
97 patients
98 peripheral blood B cells
99 plasma B
100 plasma BAFF levels
101 plasma levels
102 population
103 production
104 quantitative ELISA
105 role
106 sBAFF
107 scanning cytometry
108 significant antiapoptotic effect
109 soluble BAFF
110 special emphasis
111 stimulation
112 study
113 survival
114 susceptibility
115 syndrome
116 tendency
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