Crystal and Molecular Structure of (S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02

AUTHORS

Gang Chen, Ying Tang, Qun-Zheng Zhang, Mei Meng, Xiao-Jiang Hao

ABSTRACT

(S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide was synthesized from Cbz-l-proline through two steps and characterized by NMR and MS. The crystal structure was determined from single-crystal X-ray diffraction data. It crystallizes in the monoclinic space group, P21, with unit cell dimensions a = 7.284(6) Å, b = 10.262(9) Å, and c = 7.975(7) Å, α = 90.00°, β = 114.451(14)°, γ = 90.00° and Z = 2. The absolute configuration of the chiral center is determined as S. In the crystal structure, intermolecular and intramolecular hydrogen bonds are responsible for the formation of a 1-dimensional network. [(S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide was synthesized from Cbz-l-proline through two steps and characterized by NMR and MS. The crystal structure was determined from single-crystal X-ray diffraction data. It crystallizes in the monoclinic space group, P21, with unit cell dimensions a = 7.284(6) Å, b = 10.262(9) Å, and c = 7.975(7) Å, α = 90.00°, β = 114.451(14)°, γ = 90.00° and Z = 2. The absolute configuration of the chiral center is determined as S. In the crystal structure, intermolecular and intramolecular hydrogen bonds are responsible for the formation of a 1-dimensional network. More... »

PAGES

251-254

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10870-010-9935-z

DOI

http://dx.doi.org/10.1007/s10870-010-9935-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027418980


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