X-ray Crystallographic Structure of the Potent Antiplasmodial Compound 2,7-Dibromocryptolepine Acetic Acid Solvate View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11

AUTHORS

Brian S. Potter, John N. Lisgarten, James E. Pitts, Rex A. Palmer, Colin W. Wright

ABSTRACT

The structure of 2,7-dibromocryptolepine acetic acid solvate, C16H11N2Br2 [1.5(C2H4O2)][C2H3O2−][0.5H2O], Mr = 460.17, has been determined from X-ray diffraction data. The crystals are monoclinic, space group P21/c with Z = 4 molecules per unit cell and a = 7.3243(3), b = 18.7804(6), c = 15.8306(7) Å, β = 94.279(1)°, Vc = 2171.5(2) Å, crystal density Dc = 1.667 g/cm3. The structure was determined using direct methods and refined by full-matrix least-squares to a conventional R-index of 0.0496 for 4,908 reflections and 258 parameters. The cryptolepine nucleus of the 2,7-dibromocryptolepine molecule is highly planar and the two Br atoms are in this plane within 0.06 and 0.01 Å, respectively. The crystal structure is maintained via hydrogen bonding between N(10) in the cryptolepine nucleus and the oxygen of one of the three solvated acetic acid molecules. The acetic acid molecules also form hydrogen bonded chains. Acetic acid B is deprotonated and its two C–O bond lengths are equivalent, unlike those in A and C. Acetic acid C lies very close to a crystallographic centre of symmetry. To avoid overlap the two repeats cannot exist together and are subject to 50% statistical disorder. O(1C) of this methanol is furthest from the two-fold axis and its occupancy refines to a value of 1.0 and is assumed to exist alternately as a water oxygen hydrogen bonding to methanol O(1C) across the two-fold axis at a distance of 2.775 Å. The antiplasmodial activity of the analogue 2,7-dibromocryptolepine is nine times greater than that of cryptolepine itself against chloroquine-resistant Plasmodium falciparum (multi-drug resistant strain K1) with IC50 values = 0.44 and 0.049 μM, respectively. This analogue also showed promising in vivo activity against P. berghei in mice. Parasitaemia was suppressed by 91.4% compared to untreated infected control animals at a dose of 25 mg/kg given daily by i.p. injection with no apparent toxicity to the mice, in contrast to cryptolepine which was toxic to mice when given i.p. at 20 mg/kg. Further experiments showed a dose-dependent relationship with ED50 and ED90 values of 6.92 and 21.46 mg/kg/day, respectively. Although 2,7-dibromocryptolepine was not toxic to the mice its cytotoxic activity is similar to that of cryptolepine, but unlike cryptolepine it does not appear to intercalate into DNA as assessed using thermodenaturation techniques (ΔTm values = 3 and 9 °C, respectively). Like cryptolepine, 2,7-dibromocryptolepine inhibits the formation of haemozoin, but its increased antiplasmodial potency does not appear to be due to more potent inhibition of haemozoin formation, nor to increased accumulation into the acidic parasite food vacuole suggesting that 2,7-dibromocryptolepine has additional modes of action compared to cryptolepine. The X-ray structure of this compound will help to determine whether or not 2,7-dibromocryptolepine is able to intercalate into DNA and facilitate the design of new cryptolepine analogues with DNA binding properties appropriate for antimalarial (with no DNA intercalation) or anticancer (sequence-specific binding) applications. More... »

PAGES

821

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10870-008-9398-7

DOI

http://dx.doi.org/10.1007/s10870-008-9398-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043301168


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0302", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Inorganic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Crystallography, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potter", 
        "givenName": "Brian S.", 
        "id": "sg:person.015762001065.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015762001065.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Crystallography, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lisgarten", 
        "givenName": "John N.", 
        "id": "sg:person.01270741263.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270741263.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Crystallography, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pitts", 
        "givenName": "James E.", 
        "id": "sg:person.01270351472.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270351472.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Crystallography, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palmer", 
        "givenName": "Rex A.", 
        "id": "sg:person.01013714776.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013714776.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The School of Pharmacy, University of Bradford, BD7 4ER, West Yorkshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wright", 
        "givenName": "Colin W.", 
        "id": "sg:person.0612043450.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612043450.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1009519211938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003582014", 
          "https://doi.org/10.1023/a:1009519211938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889899006020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015082962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019218560", 
          "https://doi.org/10.1038/nsb729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s002188980600731x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020120347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889886089835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020168478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10870-008-9397-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021588487", 
          "https://doi.org/10.1007/s10870-008-9397-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10870-008-9397-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021588487", 
          "https://doi.org/10.1007/s10870-008-9397-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889896014628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026248525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889897003117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030678188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)77028-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041442837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767394005726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046337108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi972927q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055215186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi972927q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055215186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010929+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm010929+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055946879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm040893w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm040893w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948797"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "The structure of 2,7-dibromocryptolepine acetic acid solvate, C16H11N2Br2 [1.5(C2H4O2)][C2H3O2\u2212][0.5H2O], Mr = 460.17, has been determined from X-ray diffraction data. The crystals are monoclinic, space group P21/c with Z = 4 molecules per unit cell and a = 7.3243(3), b = 18.7804(6), c = 15.8306(7) \u00c5, \u03b2 = 94.279(1)\u00b0, Vc = 2171.5(2) \u00c5, crystal density Dc = 1.667 g/cm3. The structure was determined using direct methods and refined by full-matrix least-squares to a conventional R-index of 0.0496 for 4,908 reflections and 258 parameters. The cryptolepine nucleus of the 2,7-dibromocryptolepine molecule is highly planar and the two Br atoms are in this plane within 0.06 and 0.01 \u00c5, respectively. The crystal structure is maintained via hydrogen bonding between N(10) in the cryptolepine nucleus and the oxygen of one of the three solvated acetic acid molecules. The acetic acid molecules also form hydrogen bonded chains. Acetic acid B is deprotonated and its two C\u2013O bond lengths are equivalent, unlike those in A and C. Acetic acid C lies very close to a crystallographic centre of symmetry. To avoid overlap the two repeats cannot exist together and are subject to 50% statistical disorder. O(1C) of this methanol is furthest from the two-fold axis and its occupancy refines to a value of 1.0 and is assumed to exist alternately as a water oxygen hydrogen bonding to methanol O(1C) across the two-fold axis at a distance of 2.775 \u00c5. The antiplasmodial activity of the analogue 2,7-dibromocryptolepine is nine times greater than that of cryptolepine itself against chloroquine-resistant Plasmodium falciparum (multi-drug resistant strain K1) with IC50 values = 0.44 and 0.049 \u03bcM, respectively. This analogue also showed promising in vivo activity against P. berghei in mice. Parasitaemia was suppressed by 91.4% compared to untreated infected control animals at a dose of 25 mg/kg given daily by i.p. injection with no apparent toxicity to the mice, in contrast to cryptolepine which was toxic to mice when given i.p. at 20 mg/kg. Further experiments showed a dose-dependent relationship with ED50 and ED90 values of 6.92 and 21.46 mg/kg/day, respectively. Although 2,7-dibromocryptolepine was not toxic to the mice its cytotoxic activity is similar to that of cryptolepine, but unlike cryptolepine it does not appear to intercalate into DNA as assessed using thermodenaturation techniques (\u0394Tm values = 3 and 9 \u00b0C, respectively). Like cryptolepine, 2,7-dibromocryptolepine inhibits the formation of haemozoin, but its increased antiplasmodial potency does not appear to be due to more potent inhibition of haemozoin formation, nor to increased accumulation into the acidic parasite food vacuole suggesting that 2,7-dibromocryptolepine has additional modes of action compared to cryptolepine. The X-ray structure of this compound will help to determine whether or not 2,7-dibromocryptolepine is able to intercalate into DNA and facilitate the design of new cryptolepine analogues with DNA binding properties appropriate for antimalarial (with no DNA intercalation) or anticancer (sequence-specific binding) applications.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10870-008-9398-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1093566", 
        "issn": [
          "1074-1542", 
          "1572-8854"
        ], 
        "name": "Journal of Chemical Crystallography", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "X-ray Crystallographic Structure of the Potent Antiplasmodial Compound 2,7-Dibromocryptolepine Acetic Acid Solvate", 
    "pagination": "821", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10870-008-9398-7"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ce426d59bd70a9e09d08a00fc81d7520880d63307747228584de43235498139f"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043301168"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10870-008-9398-7", 
      "https://app.dimensions.ai/details/publication/pub.1043301168"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56154_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10870-008-9398-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10870-008-9398-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10870-008-9398-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10870-008-9398-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10870-008-9398-7'


 

This table displays all metadata directly associated to this object as RDF triples.

135 TRIPLES      21 PREDICATES      41 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10870-008-9398-7 schema:about anzsrc-for:03
2 anzsrc-for:0302
3 schema:author N3c6bf56d259748238f26d6063dbe4524
4 schema:citation sg:pub.10.1007/s10870-008-9397-8
5 sg:pub.10.1023/a:1009519211938
6 sg:pub.10.1038/nsb729
7 https://doi.org/10.1016/s0076-6879(97)76066-x
8 https://doi.org/10.1016/s0076-6879(97)77028-9
9 https://doi.org/10.1021/bi972927q
10 https://doi.org/10.1021/jm010929+
11 https://doi.org/10.1021/jm040893w
12 https://doi.org/10.1107/s002188980600731x
13 https://doi.org/10.1107/s0021889886089835
14 https://doi.org/10.1107/s0021889896014628
15 https://doi.org/10.1107/s0021889897003117
16 https://doi.org/10.1107/s0021889899006020
17 https://doi.org/10.1107/s0108767394005726
18 schema:datePublished 2008-11
19 schema:datePublishedReg 2008-11-01
20 schema:description The structure of 2,7-dibromocryptolepine acetic acid solvate, C16H11N2Br2 [1.5(C2H4O2)][C2H3O2−][0.5H2O], Mr = 460.17, has been determined from X-ray diffraction data. The crystals are monoclinic, space group P21/c with Z = 4 molecules per unit cell and a = 7.3243(3), b = 18.7804(6), c = 15.8306(7) Å, β = 94.279(1)°, Vc = 2171.5(2) Å, crystal density Dc = 1.667 g/cm3. The structure was determined using direct methods and refined by full-matrix least-squares to a conventional R-index of 0.0496 for 4,908 reflections and 258 parameters. The cryptolepine nucleus of the 2,7-dibromocryptolepine molecule is highly planar and the two Br atoms are in this plane within 0.06 and 0.01 Å, respectively. The crystal structure is maintained via hydrogen bonding between N(10) in the cryptolepine nucleus and the oxygen of one of the three solvated acetic acid molecules. The acetic acid molecules also form hydrogen bonded chains. Acetic acid B is deprotonated and its two C–O bond lengths are equivalent, unlike those in A and C. Acetic acid C lies very close to a crystallographic centre of symmetry. To avoid overlap the two repeats cannot exist together and are subject to 50% statistical disorder. O(1C) of this methanol is furthest from the two-fold axis and its occupancy refines to a value of 1.0 and is assumed to exist alternately as a water oxygen hydrogen bonding to methanol O(1C) across the two-fold axis at a distance of 2.775 Å. The antiplasmodial activity of the analogue 2,7-dibromocryptolepine is nine times greater than that of cryptolepine itself against chloroquine-resistant Plasmodium falciparum (multi-drug resistant strain K1) with IC50 values = 0.44 and 0.049 μM, respectively. This analogue also showed promising in vivo activity against P. berghei in mice. Parasitaemia was suppressed by 91.4% compared to untreated infected control animals at a dose of 25 mg/kg given daily by i.p. injection with no apparent toxicity to the mice, in contrast to cryptolepine which was toxic to mice when given i.p. at 20 mg/kg. Further experiments showed a dose-dependent relationship with ED50 and ED90 values of 6.92 and 21.46 mg/kg/day, respectively. Although 2,7-dibromocryptolepine was not toxic to the mice its cytotoxic activity is similar to that of cryptolepine, but unlike cryptolepine it does not appear to intercalate into DNA as assessed using thermodenaturation techniques (ΔTm values = 3 and 9 °C, respectively). Like cryptolepine, 2,7-dibromocryptolepine inhibits the formation of haemozoin, but its increased antiplasmodial potency does not appear to be due to more potent inhibition of haemozoin formation, nor to increased accumulation into the acidic parasite food vacuole suggesting that 2,7-dibromocryptolepine has additional modes of action compared to cryptolepine. The X-ray structure of this compound will help to determine whether or not 2,7-dibromocryptolepine is able to intercalate into DNA and facilitate the design of new cryptolepine analogues with DNA binding properties appropriate for antimalarial (with no DNA intercalation) or anticancer (sequence-specific binding) applications.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N9e9f2b67996a458bb46027a37812d386
25 Na935e73119cd4148a0ce6133efcaefae
26 sg:journal.1093566
27 schema:name X-ray Crystallographic Structure of the Potent Antiplasmodial Compound 2,7-Dibromocryptolepine Acetic Acid Solvate
28 schema:pagination 821
29 schema:productId N01363ad339c2425fb08955ac45196505
30 N362180bae3da41f295b5cdad065f316e
31 N83033c5acf0448ed92cdc3999f967265
32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043301168
33 https://doi.org/10.1007/s10870-008-9398-7
34 schema:sdDatePublished 2019-04-15T09:08
35 schema:sdLicense https://scigraph.springernature.com/explorer/license/
36 schema:sdPublisher N6c19a5505a884f77a2b2aa80be02fafb
37 schema:url http://link.springer.com/10.1007/s10870-008-9398-7
38 sgo:license sg:explorer/license/
39 sgo:sdDataset articles
40 rdf:type schema:ScholarlyArticle
41 N01363ad339c2425fb08955ac45196505 schema:name doi
42 schema:value 10.1007/s10870-008-9398-7
43 rdf:type schema:PropertyValue
44 N362180bae3da41f295b5cdad065f316e schema:name readcube_id
45 schema:value ce426d59bd70a9e09d08a00fc81d7520880d63307747228584de43235498139f
46 rdf:type schema:PropertyValue
47 N3c6bf56d259748238f26d6063dbe4524 rdf:first sg:person.015762001065.56
48 rdf:rest N9b8ec50179dd4fa1b35a62c5568b3eb3
49 N56d7003fea14443d94dbfbdb1c834be3 rdf:first sg:person.01013714776.39
50 rdf:rest Nbabba572c3fd479f838da76d56988f68
51 N6c19a5505a884f77a2b2aa80be02fafb schema:name Springer Nature - SN SciGraph project
52 rdf:type schema:Organization
53 N83033c5acf0448ed92cdc3999f967265 schema:name dimensions_id
54 schema:value pub.1043301168
55 rdf:type schema:PropertyValue
56 N9b8ec50179dd4fa1b35a62c5568b3eb3 rdf:first sg:person.01270741263.28
57 rdf:rest Nde007a8a305244948652a577c7fe61ea
58 N9e9f2b67996a458bb46027a37812d386 schema:issueNumber 11
59 rdf:type schema:PublicationIssue
60 Na935e73119cd4148a0ce6133efcaefae schema:volumeNumber 38
61 rdf:type schema:PublicationVolume
62 Nbabba572c3fd479f838da76d56988f68 rdf:first sg:person.0612043450.78
63 rdf:rest rdf:nil
64 Nde007a8a305244948652a577c7fe61ea rdf:first sg:person.01270351472.33
65 rdf:rest N56d7003fea14443d94dbfbdb1c834be3
66 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
67 schema:name Chemical Sciences
68 rdf:type schema:DefinedTerm
69 anzsrc-for:0302 schema:inDefinedTermSet anzsrc-for:
70 schema:name Inorganic Chemistry
71 rdf:type schema:DefinedTerm
72 sg:journal.1093566 schema:issn 1074-1542
73 1572-8854
74 schema:name Journal of Chemical Crystallography
75 rdf:type schema:Periodical
76 sg:person.01013714776.39 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
77 schema:familyName Palmer
78 schema:givenName Rex A.
79 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013714776.39
80 rdf:type schema:Person
81 sg:person.01270351472.33 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
82 schema:familyName Pitts
83 schema:givenName James E.
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270351472.33
85 rdf:type schema:Person
86 sg:person.01270741263.28 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
87 schema:familyName Lisgarten
88 schema:givenName John N.
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270741263.28
90 rdf:type schema:Person
91 sg:person.015762001065.56 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
92 schema:familyName Potter
93 schema:givenName Brian S.
94 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015762001065.56
95 rdf:type schema:Person
96 sg:person.0612043450.78 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
97 schema:familyName Wright
98 schema:givenName Colin W.
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612043450.78
100 rdf:type schema:Person
101 sg:pub.10.1007/s10870-008-9397-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021588487
102 https://doi.org/10.1007/s10870-008-9397-8
103 rdf:type schema:CreativeWork
104 sg:pub.10.1023/a:1009519211938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003582014
105 https://doi.org/10.1023/a:1009519211938
106 rdf:type schema:CreativeWork
107 sg:pub.10.1038/nsb729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019218560
108 https://doi.org/10.1038/nsb729
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/s0076-6879(97)77028-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041442837
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1021/bi972927q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055215186
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1021/jm010929+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1055946879
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1021/jm040893w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055948797
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1107/s002188980600731x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020120347
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1107/s0021889886089835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020168478
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1107/s0021889896014628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026248525
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1107/s0021889897003117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030678188
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1107/s0021889899006020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015082962
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1107/s0108767394005726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046337108
131 rdf:type schema:CreativeWork
132 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
133 schema:name School of Crystallography, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK
134 The School of Pharmacy, University of Bradford, BD7 4ER, West Yorkshire, UK
135 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...