Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSN. Jennifer Klinedinst, Rosemary Schuh, Steven J. Kittner, William T. Regenold, Glenn Kehs, Christine Hoch, Alisha Hackney, Gary Fiskum
ABSTRACTApproximately half of stroke survivors suffer from clinically significant fatigue, contributing to poor quality of life, depression, dependency, and increased mortality. The etiology of post-stroke fatigue is not well understood and treatment is limited. This study tested the hypothesis that systemic aerobic energy metabolism, as reflected by platelet oxygen consumption, is negatively associated with fatigue and systemic inflammation is positively associated with fatigue in chronic ischemic stroke survivors. Data on self-reported level of fatigue, platelet oxygen consumption rates (OCR) and plasma inflammatory markers were analyzed from 20 ischemic stroke survivors. DNA copy number for two mitochondrial genes was measured as a marker of platelet mitochondrial content. Basal and protonophore-stimulated maximal platelet OCR showed a biphasic relationship to fatigue. Platelet OCR was negatively associated with low to moderate fatigue but was positively associated with moderate to high fatigue. DNA copy number was not associated with either fatigue or platelet OCR. Fatigue was negatively associated with C-reactive protein but not with other inflammatory markers. Post-stroke fatigue may be indicative of a systemic cellular energy dysfunction that is reflected in platelet energy metabolism. The biphasic relationship of fatigue to platelet OCR may indicate an ineffective bioenergetic compensatory response that has been observed in other pathological states. More... »
PAGES165-174
http://scigraph.springernature.com/pub.10.1007/s10863-018-9782-8
DOIhttp://dx.doi.org/10.1007/s10863-018-9782-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111245821
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30617735
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Nursing, Room 325B, 655 W. Lombard Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Klinedinst",
"givenName": "N. Jennifer",
"id": "sg:person.0726762723.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726762723.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Medicine, 655 W. Baltimore Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Schuh",
"givenName": "Rosemary",
"id": "sg:person.01340426650.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340426650.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Baltimore VA Medical Center",
"id": "https://www.grid.ac/institutes/grid.280711.d",
"name": [
"University of Maryland School of Medicine, 655 W. Baltimore Street, 21201, Baltimore, MD, USA",
"Baltimore Veterans Administration Medical Center, 10 N. Greene Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Kittner",
"givenName": "Steven J.",
"id": "sg:person.016415147057.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016415147057.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Medicine, 655 W. Baltimore Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Regenold",
"givenName": "William T.",
"id": "sg:person.01115063244.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115063244.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Medicine, 655 W. Baltimore Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Kehs",
"givenName": "Glenn",
"id": "sg:person.0665337530.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665337530.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Nursing, Room 325B, 655 W. Lombard Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hoch",
"givenName": "Christine",
"id": "sg:person.014175134064.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014175134064.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Nursing, Room 325B, 655 W. Lombard Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hackney",
"givenName": "Alisha",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Maryland, Baltimore",
"id": "https://www.grid.ac/institutes/grid.411024.2",
"name": [
"University of Maryland School of Medicine, 655 W. Baltimore Street, 21201, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Fiskum",
"givenName": "Gary",
"id": "sg:person.01307572755.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307572755.50"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s12035-015-9090-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001497552",
"https://doi.org/10.1007/s12035-015-9090-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.2013.53",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001640730",
"https://doi.org/10.1038/labinvest.2013.53"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jneuroim.2009.08.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004020791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmjopen-2012-002404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007359117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/jgs.12876",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008606448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mrr.0b013e328010c7b8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008816588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mrr.0b013e328010c7b8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008816588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mito.2013.05.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010981137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000139660",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012186644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-291x(88)81291-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014618453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2013/434010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016166296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0404.2011.01618.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016691253"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1479-5876-7-97",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017565580",
"https://doi.org/10.1186/1479-5876-7-97"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.114.006647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020330938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.114.006647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020330938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.114.006647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020330938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/09638288.2011.645111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021068623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1189/jlb.0212078",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021982717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.10685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026616436"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11011-013-9435-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031401827",
"https://doi.org/10.1007/s11011-013-9435-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.106.478941",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032502237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.106.478941",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032502237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jocn.2013.06.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033020413"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc9337",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034022927",
"https://doi.org/10.1186/cc9337"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc9337",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034022927",
"https://doi.org/10.1186/cc9337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.redox.2013.12.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036805666"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0097673",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036885475"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10863-016-9657-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037102862",
"https://doi.org/10.1007/s10863-016-9657-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-3999(02)00392-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037199234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-3999(02)00392-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037199234"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1741-7015-11-205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037449833",
"https://doi.org/10.1186/1741-7015-11-205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.redox.2016.09.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038634513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1532-5415.2008.01925.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038858526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd007030.pub3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039886467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0736-4679(99)00135-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039907950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1532-5415.2010.02811.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042112790"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/jan.12002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043922083"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4939-1875-1_3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044338120",
"https://doi.org/10.1007/978-1-4939-1875-1_3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/gerona/glu096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044791720"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.108.527101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045166744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.108.527101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045166744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3791/51301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046082386"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12916-014-0259-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046399665",
"https://doi.org/10.1186/s12916-014-0259-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12916-014-0259-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046399665",
"https://doi.org/10.1186/s12916-014-0259-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/02699052.2010.531687",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048267587"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jocn.2005.07.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049332938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/hsz-2012-0198",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051302787"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00415-011-5962-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052702276",
"https://doi.org/10.1007/s00415-011-5962-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.10.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053377569"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1027/1015-5759.20.1.39",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056344133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4997/jrcpe.2010.103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072533021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4997/jrcpe.2010.103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072533021"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074643566",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/str.0000000000000132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085618996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/str.0000000000000132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085618996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2017/7317251",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092048253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bsr20180286",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103256797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bsr20180286",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103256797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2017.35.15_suppl.10018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106845503"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "Approximately half of stroke survivors suffer from clinically significant fatigue, contributing to poor quality of life, depression, dependency, and increased mortality. The etiology of post-stroke fatigue is not well understood and treatment is limited. This study tested the hypothesis that systemic aerobic energy metabolism, as reflected by platelet oxygen consumption, is negatively associated with fatigue and systemic inflammation is positively associated with fatigue in chronic ischemic stroke survivors. Data on self-reported level of fatigue, platelet oxygen consumption rates (OCR) and plasma inflammatory markers were analyzed from 20 ischemic stroke survivors. DNA copy number for two mitochondrial genes was measured as a marker of platelet mitochondrial content. Basal and protonophore-stimulated maximal platelet OCR showed a biphasic relationship to fatigue. Platelet OCR was negatively associated with low to moderate fatigue but was positively associated with moderate to high fatigue. DNA copy number was not associated with either fatigue or platelet OCR. Fatigue was negatively associated with C-reactive protein but not with other inflammatory markers. Post-stroke fatigue may be indicative of a systemic cellular energy dysfunction that is reflected in platelet energy metabolism. The biphasic relationship of fatigue to platelet OCR may indicate an ineffective bioenergetic compensatory response that has been observed in other pathological states.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10863-018-9782-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1055350",
"issn": [
"0145-479X",
"1573-6881"
],
"name": "Journal of Bioenergetics and Biomembranes",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "51"
}
],
"name": "Post-stroke fatigue as an indicator of underlying bioenergetics alterations",
"pagination": "165-174",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"49b3c1c89df609f3dfcffc716222210a79bafffcb29eceff3d471aa6723c9b63"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30617735"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7701859"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10863-018-9782-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111245821"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10863-018-9782-8",
"https://app.dimensions.ai/details/publication/pub.1111245821"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:28",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46741_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10863-018-9782-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10863-018-9782-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10863-018-9782-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10863-018-9782-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10863-018-9782-8'
This table displays all metadata directly associated to this object as RDF triples.
275 TRIPLES
21 PREDICATES
77 URIs
21 LITERALS
9 BLANK NODES