Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06

AUTHORS

Zixuan Zhang, Zhirui Zhang, Qixiang Li, Hao Jiao, Dianlong Chong, Xiaojin Sun, Pei Zhang, Qiang Huo, Hao Liu

ABSTRACT

Shikonin, a natural small agent, has shown inhibitory effect in many kinds of cells, which increases intracellular reactive oxygen species (ROS) level and causes mitochondrial injury. In this study, shikonin showed good inhibitory effect on nasopharyngeal carcinoma CNE-2Z cells in vivo and vitro. The results presented here revealed that ROS levels increased markly after shikonin treated. The electron microscopy displays the change in ultrastructure of CNE-2Z cells after treatment for shikonin, which indicated that shikonin induced necroptosis. Shikonin-induced cell death was inhibited by a necroptosis inhibitor, necrostatin-1 (Nec-1), while the activity was unaffected by the caspase inhibitor z-VAD-fmk. Furthermore, we have demonstrated that the activation of receptor-interacting kinase (RIP) led to necroptosis. Meanwhile, shikonin also significantly inhibited tumor growth in a CNE-2Z xenograft mouse model. Taken together, shikonin induced CNE-2Z cells death by producing ROS as a necroptosis inducer. It could serve as a new therapeutic agent for treating CNE-2Z cells. More... »

PAGES

265-272

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10863-017-9714-z

DOI

http://dx.doi.org/10.1007/s10863-017-9714-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085595640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28547157


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents, Non-Steroidal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterografts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthoquinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Clinical medicine, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zixuan", 
        "id": "sg:person.016714636145.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016714636145.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhirui", 
        "id": "sg:person.013046521261.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046521261.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Qixiang", 
        "id": "sg:person.015321675145.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015321675145.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiao", 
        "givenName": "Hao", 
        "id": "sg:person.01061150730.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061150730.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chong", 
        "givenName": "Dianlong", 
        "id": "sg:person.012251140661.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012251140661.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Xiaojin", 
        "id": "sg:person.01311227721.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311227721.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Pei", 
        "id": "sg:person.0576511402.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576511402.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huo", 
        "givenName": "Qiang", 
        "id": "sg:person.0644352563.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644352563.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Hao", 
        "id": "sg:person.01212142420.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212142420.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/cdd.2014.126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000198075", 
          "https://doi.org/10.1038/cdd.2014.126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1310050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004642273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2011.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009182541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2011.02.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013326910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-015-4258-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013583450", 
          "https://doi.org/10.1007/s13277-015-4258-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00055-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013646435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00055-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013646435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2012.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014085861", 
          "https://doi.org/10.1038/cddis.2012.64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep24835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015399559", 
          "https://doi.org/10.1038/srep24835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep24835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015399559", 
          "https://doi.org/10.1038/srep24835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2015.07.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017732936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2013.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024739375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025034761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-016-0428-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032880004", 
          "https://doi.org/10.1186/s13046-016-0428-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-016-0428-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032880004", 
          "https://doi.org/10.1186/s13046-016-0428-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033614738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.33.816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035207073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/23723556.2014.975093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035633574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2014.2804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042084983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2014.2804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042084983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/726025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043021616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2013.14.12.7069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046177926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046690609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules21060777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048508319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2015.16.16.7261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051415089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.3582006pe44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062693505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157340611796799104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069209459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mmr.2016.4967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071523641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mmr.2016.4967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071523641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082538056", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.epirev.a036130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082686466"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "Shikonin, a natural small agent, has shown inhibitory effect in many kinds of cells, which increases intracellular reactive oxygen species (ROS) level and causes mitochondrial injury. In this study, shikonin showed good inhibitory effect on nasopharyngeal carcinoma CNE-2Z cells in vivo and vitro. The results presented here revealed that ROS levels increased markly after shikonin treated. The electron microscopy displays the change in ultrastructure of CNE-2Z cells after treatment for shikonin, which indicated that shikonin induced necroptosis. Shikonin-induced cell death was inhibited by a necroptosis inhibitor, necrostatin-1 (Nec-1), while the activity was unaffected by the caspase inhibitor z-VAD-fmk. Furthermore, we have demonstrated that the activation of receptor-interacting kinase (RIP) led to necroptosis. Meanwhile, shikonin also significantly inhibited tumor growth in a CNE-2Z xenograft mouse model. Taken together, shikonin induced CNE-2Z cells death by producing ROS as a necroptosis inducer. It could serve as a new therapeutic agent for treating CNE-2Z cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10863-017-9714-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1055350", 
        "issn": [
          "0145-479X", 
          "1573-6881"
        ], 
        "name": "Journal of Bioenergetics and Biomembranes", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "name": "Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z", 
    "pagination": "265-272", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "714237e94fd10ab7e15308ded63df2559e22bbfdd9b189b7007d71008d6c0686"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28547157"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7701859"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10863-017-9714-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085595640"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10863-017-9714-z", 
      "https://app.dimensions.ai/details/publication/pub.1085595640"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99824_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10863-017-9714-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10863-017-9714-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10863-017-9714-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10863-017-9714-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10863-017-9714-z'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      69 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10863-017-9714-z schema:about N2447492a9ba34447b7a0b13e9d7269e0
2 N261631453d1f430b8052446ff3b79608
3 N34893e35df2341d19c8e77de54244640
4 N3923f398f8ee48a0a39a2288849efb42
5 N3d16911543ec4c0484037d872aa7e603
6 N44ed6b23c62a45038bd9e3c5df7ae7d1
7 N67128f75f3f542dc93a283f2a2528f60
8 N6ce3ddf110e94daa88587a8c9fb701de
9 N8880b833c37b4ccb955af7a5be082142
10 N8aaf2a74a2f945d29ea427792b861e37
11 N949510ebada34c29bce01b85896adc6f
12 Na2d70aa7798343d2900065a2722cd7db
13 Na91e1cef5cff4a17937c9569bf68f2c1
14 Nf0be7a86380748839fa8ca92b622cb7d
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author Nf91c89cfafd94ed1aaf11c528ba8f2b5
18 schema:citation sg:pub.10.1007/s13277-015-4258-5
19 sg:pub.10.1038/cdd.2014.126
20 sg:pub.10.1038/cddis.2012.64
21 sg:pub.10.1038/srep24835
22 sg:pub.10.1186/s13046-016-0428-6
23 https://app.dimensions.ai/details/publication/pub.1082538056
24 https://doi.org/10.1016/j.bbrc.2015.07.054
25 https://doi.org/10.1016/j.cell.2012.06.019
26 https://doi.org/10.1016/j.ejphar.2011.02.043
27 https://doi.org/10.1016/j.freeradbiomed.2011.09.018
28 https://doi.org/10.1016/j.intimp.2013.04.020
29 https://doi.org/10.1016/s0140-6736(15)00055-0
30 https://doi.org/10.1056/nejmra1310050
31 https://doi.org/10.1093/oxfordjournals.epirev.a036130
32 https://doi.org/10.1126/stke.3582006pe44
33 https://doi.org/10.1155/2012/726025
34 https://doi.org/10.1248/bpb.33.816
35 https://doi.org/10.1371/journal.pone.0066326
36 https://doi.org/10.18632/oncotarget.3038
37 https://doi.org/10.2174/157340611796799104
38 https://doi.org/10.3390/molecules21060777
39 https://doi.org/10.3892/ijo.2014.2804
40 https://doi.org/10.3892/mmr.2016.4967
41 https://doi.org/10.4161/23723556.2014.975093
42 https://doi.org/10.7314/apjcp.2013.14.12.7069
43 https://doi.org/10.7314/apjcp.2015.16.16.7261
44 schema:datePublished 2017-06
45 schema:datePublishedReg 2017-06-01
46 schema:description Shikonin, a natural small agent, has shown inhibitory effect in many kinds of cells, which increases intracellular reactive oxygen species (ROS) level and causes mitochondrial injury. In this study, shikonin showed good inhibitory effect on nasopharyngeal carcinoma CNE-2Z cells in vivo and vitro. The results presented here revealed that ROS levels increased markly after shikonin treated. The electron microscopy displays the change in ultrastructure of CNE-2Z cells after treatment for shikonin, which indicated that shikonin induced necroptosis. Shikonin-induced cell death was inhibited by a necroptosis inhibitor, necrostatin-1 (Nec-1), while the activity was unaffected by the caspase inhibitor z-VAD-fmk. Furthermore, we have demonstrated that the activation of receptor-interacting kinase (RIP) led to necroptosis. Meanwhile, shikonin also significantly inhibited tumor growth in a CNE-2Z xenograft mouse model. Taken together, shikonin induced CNE-2Z cells death by producing ROS as a necroptosis inducer. It could serve as a new therapeutic agent for treating CNE-2Z cells.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N17f0b2a2d432410ab6500b84b98306b2
51 Ne46e20cec22940aa80a9ed14ba50b9ab
52 sg:journal.1055350
53 schema:name Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z
54 schema:pagination 265-272
55 schema:productId N21d976e6122e4dcaa5015b8ef9b56bd4
56 N2bfa9cd2b6ee432f91d34a0517329bb7
57 N63cc9620019c488383975e0f7beb46a7
58 N7d585cedb6e047cdae13d75cfe946a7f
59 Nd371d381f1414d328d8419f521c9057b
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085595640
61 https://doi.org/10.1007/s10863-017-9714-z
62 schema:sdDatePublished 2019-04-11T09:36
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N67f1973d906143c2b452311546053ae8
65 schema:url https://link.springer.com/10.1007%2Fs10863-017-9714-z
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N17f0b2a2d432410ab6500b84b98306b2 schema:issueNumber 3
70 rdf:type schema:PublicationIssue
71 N21d976e6122e4dcaa5015b8ef9b56bd4 schema:name doi
72 schema:value 10.1007/s10863-017-9714-z
73 rdf:type schema:PropertyValue
74 N2447492a9ba34447b7a0b13e9d7269e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Nasopharyngeal Carcinoma
76 rdf:type schema:DefinedTerm
77 N261631453d1f430b8052446ff3b79608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Necrosis
79 rdf:type schema:DefinedTerm
80 N2bfa9cd2b6ee432f91d34a0517329bb7 schema:name pubmed_id
81 schema:value 28547157
82 rdf:type schema:PropertyValue
83 N34893e35df2341d19c8e77de54244640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Reactive Oxygen Species
85 rdf:type schema:DefinedTerm
86 N3923f398f8ee48a0a39a2288849efb42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Anti-Inflammatory Agents, Non-Steroidal
88 rdf:type schema:DefinedTerm
89 N3d16911543ec4c0484037d872aa7e603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mice, Nude
91 rdf:type schema:DefinedTerm
92 N3d561692738c448d877af075919be575 rdf:first sg:person.012251140661.74
93 rdf:rest Nfdffede2112741629fdb78a0ad676803
94 N44ed6b23c62a45038bd9e3c5df7ae7d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Apoptosis
96 rdf:type schema:DefinedTerm
97 N5932d934b78942aeb86f409a2f65dccb rdf:first sg:person.0644352563.31
98 rdf:rest N69fda8a593e444cea57d4787e2b4bc6b
99 N6030628a34914be7a83dc7b15a0247ea rdf:first sg:person.0576511402.83
100 rdf:rest N5932d934b78942aeb86f409a2f65dccb
101 N63cc9620019c488383975e0f7beb46a7 schema:name nlm_unique_id
102 schema:value 7701859
103 rdf:type schema:PropertyValue
104 N67128f75f3f542dc93a283f2a2528f60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Naphthoquinones
106 rdf:type schema:DefinedTerm
107 N67f1973d906143c2b452311546053ae8 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N69fda8a593e444cea57d4787e2b4bc6b rdf:first sg:person.01212142420.00
110 rdf:rest rdf:nil
111 N6aaac40e74b54873b73181f04c0c35a8 rdf:first sg:person.013046521261.54
112 rdf:rest Nbdc91a49f68a4acc8ab126af5901efbf
113 N6ce3ddf110e94daa88587a8c9fb701de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Carcinoma
115 rdf:type schema:DefinedTerm
116 N7d585cedb6e047cdae13d75cfe946a7f schema:name readcube_id
117 schema:value 714237e94fd10ab7e15308ded63df2559e22bbfdd9b189b7007d71008d6c0686
118 rdf:type schema:PropertyValue
119 N8880b833c37b4ccb955af7a5be082142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cell Line, Tumor
121 rdf:type schema:DefinedTerm
122 N8aaf2a74a2f945d29ea427792b861e37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Heterografts
124 rdf:type schema:DefinedTerm
125 N949510ebada34c29bce01b85896adc6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 Na2d70aa7798343d2900065a2722cd7db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Animals
130 rdf:type schema:DefinedTerm
131 Na91e1cef5cff4a17937c9569bf68f2c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Nasopharyngeal Neoplasms
133 rdf:type schema:DefinedTerm
134 Nbdc91a49f68a4acc8ab126af5901efbf rdf:first sg:person.015321675145.16
135 rdf:rest Ne27d52283ed241d5ba4a13f4735411ce
136 Nd371d381f1414d328d8419f521c9057b schema:name dimensions_id
137 schema:value pub.1085595640
138 rdf:type schema:PropertyValue
139 Ne27d52283ed241d5ba4a13f4735411ce rdf:first sg:person.01061150730.81
140 rdf:rest N3d561692738c448d877af075919be575
141 Ne46e20cec22940aa80a9ed14ba50b9ab schema:volumeNumber 49
142 rdf:type schema:PublicationVolume
143 Nf0be7a86380748839fa8ca92b622cb7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 Nf91c89cfafd94ed1aaf11c528ba8f2b5 rdf:first sg:person.016714636145.84
147 rdf:rest N6aaac40e74b54873b73181f04c0c35a8
148 Nfdffede2112741629fdb78a0ad676803 rdf:first sg:person.01311227721.52
149 rdf:rest N6030628a34914be7a83dc7b15a0247ea
150 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
151 schema:name Biological Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biochemistry and Cell Biology
155 rdf:type schema:DefinedTerm
156 sg:journal.1055350 schema:issn 0145-479X
157 1573-6881
158 schema:name Journal of Bioenergetics and Biomembranes
159 rdf:type schema:Periodical
160 sg:person.01061150730.81 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
161 schema:familyName Jiao
162 schema:givenName Hao
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061150730.81
164 rdf:type schema:Person
165 sg:person.01212142420.00 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
166 schema:familyName Liu
167 schema:givenName Hao
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212142420.00
169 rdf:type schema:Person
170 sg:person.012251140661.74 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
171 schema:familyName Chong
172 schema:givenName Dianlong
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012251140661.74
174 rdf:type schema:Person
175 sg:person.013046521261.54 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
176 schema:familyName Zhang
177 schema:givenName Zhirui
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046521261.54
179 rdf:type schema:Person
180 sg:person.01311227721.52 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
181 schema:familyName Sun
182 schema:givenName Xiaojin
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311227721.52
184 rdf:type schema:Person
185 sg:person.015321675145.16 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
186 schema:familyName Li
187 schema:givenName Qixiang
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015321675145.16
189 rdf:type schema:Person
190 sg:person.016714636145.84 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
191 schema:familyName Zhang
192 schema:givenName Zixuan
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016714636145.84
194 rdf:type schema:Person
195 sg:person.0576511402.83 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
196 schema:familyName Zhang
197 schema:givenName Pei
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576511402.83
199 rdf:type schema:Person
200 sg:person.0644352563.31 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
201 schema:familyName Huo
202 schema:givenName Qiang
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644352563.31
204 rdf:type schema:Person
205 sg:pub.10.1007/s13277-015-4258-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013583450
206 https://doi.org/10.1007/s13277-015-4258-5
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/cdd.2014.126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000198075
209 https://doi.org/10.1038/cdd.2014.126
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/cddis.2012.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014085861
212 https://doi.org/10.1038/cddis.2012.64
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/srep24835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015399559
215 https://doi.org/10.1038/srep24835
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/s13046-016-0428-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032880004
218 https://doi.org/10.1186/s13046-016-0428-6
219 rdf:type schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1082538056 schema:CreativeWork
221 https://doi.org/10.1016/j.bbrc.2015.07.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017732936
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.cell.2012.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046690609
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ejphar.2011.02.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013326910
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.freeradbiomed.2011.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009182541
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.intimp.2013.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024739375
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0140-6736(15)00055-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013646435
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1056/nejmra1310050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004642273
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/oxfordjournals.epirev.a036130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082686466
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1126/stke.3582006pe44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062693505
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1155/2012/726025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043021616
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1248/bpb.33.816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035207073
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.pone.0066326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025034761
244 rdf:type schema:CreativeWork
245 https://doi.org/10.18632/oncotarget.3038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033614738
246 rdf:type schema:CreativeWork
247 https://doi.org/10.2174/157340611796799104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069209459
248 rdf:type schema:CreativeWork
249 https://doi.org/10.3390/molecules21060777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048508319
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3892/ijo.2014.2804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042084983
252 rdf:type schema:CreativeWork
253 https://doi.org/10.3892/mmr.2016.4967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071523641
254 rdf:type schema:CreativeWork
255 https://doi.org/10.4161/23723556.2014.975093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035633574
256 rdf:type schema:CreativeWork
257 https://doi.org/10.7314/apjcp.2013.14.12.7069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046177926
258 rdf:type schema:CreativeWork
259 https://doi.org/10.7314/apjcp.2015.16.16.7261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051415089
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.252957.e schema:alternateName Bengbu Medical College
262 schema:name Department of Clinical medicine, Bengbu Medical College, 233000, Bengbu, Anhui, People’s Republic of China
263 Faculty of Pharmacy, Bengbu Medical College, 233000, Bengbu, Anhui, People’s Republic of China
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...