Nucleic acid helix structure determination from NMR proton chemical shifts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Ramon M. van der Werf, Marco Tessari, Sybren S. Wijmenga

ABSTRACT

We present a method for de novo derivation of the three-dimensional helix structure of nucleic acids using non-exchangeable proton chemical shifts as sole source of experimental restraints. The method is called chemical shift de novo structure derivation protocol employing singular value decomposition (CHEOPS) and uses iterative singular value decomposition to optimize the structure in helix parameter space. The correct performance of CHEOPS and its range of application are established via an extensive set of structure derivations using either simulated or experimental chemical shifts as input. The simulated input data are used to assess in a defined manner the effect of errors or limitations in the input data on the derived structures. We find that the RNA helix parameters can be determined with high accuracy. We finally demonstrate via three deposited RNA structures that experimental proton chemical shifts suffice to derive RNA helix structures with high precision and accuracy. CHEOPS provides, subject to further development, new directions for high-resolution NMR structure determination of nucleic acids. More... »

PAGES

95-112

References to SciGraph publications

  • 2010-05. Structural aspects of messenger RNA reading frame maintenance by the ribosome in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2001-09. Prediction of proton chemical shifts in RNA – Their use in structure refinement and validation in JOURNAL OF BIOMOLECULAR NMR
  • 1995-12. Calibration of ring-current effects in proteins and nucleic acids in JOURNAL OF BIOMOLECULAR NMR
  • 2010-07. Major groove width variations in RNA structures determined by NMR and impact of 13C residual chemical shift anisotropy and 1H–13C residual dipolar coupling on refinement in JOURNAL OF BIOMOLECULAR NMR
  • 2006-12. Impact of static and dynamic A-form heterogeneity on the determination of RNA global structural dynamics using NMR residual dipolar couplings in JOURNAL OF BIOMOLECULAR NMR
  • 2005-10. The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer–editing conformation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-06. Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings in NATURE PROTOCOLS
  • 2010-12. RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures in BMC BIOINFORMATICS
  • 1997-12. Analysis of 1H chemical shifts in DNA: Assessment of the reliability of 1H chemical shift calculations for use in structure refinement in JOURNAL OF BIOMOLECULAR NMR
  • 1995-01. Sequential backbone assignment of uniformly 13C-labeled RNAs by a two-dimensional P(CC)H-TOCSY triple resonance NMR experiment in JOURNAL OF BIOMOLECULAR NMR
  • 2009-02. De novo protein structure generation from incomplete chemical shift assignments in JOURNAL OF BIOMOLECULAR NMR
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10858-013-9725-y

    DOI

    http://dx.doi.org/10.1007/s10858-013-9725-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051703904

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23564038


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0307", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Theoretical and Computational Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Magnetic Resonance, Biomolecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acid Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen", 
              "id": "https://www.grid.ac/institutes/grid.5590.9", 
              "name": [
                "Department of Biophysical Chemistry, Institute of Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Werf", 
            "givenName": "Ramon M.", 
            "id": "sg:person.01247472251.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247472251.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen", 
              "id": "https://www.grid.ac/institutes/grid.5590.9", 
              "name": [
                "Department of Biophysical Chemistry, Institute of Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tessari", 
            "givenName": "Marco", 
            "id": "sg:person.01271277325.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271277325.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen", 
              "id": "https://www.grid.ac/institutes/grid.5590.9", 
              "name": [
                "Department of Biophysical Chemistry, Institute of Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wijmenga", 
            "givenName": "Sybren S.", 
            "id": "sg:person.0672171122.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672171122.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10858-010-9424-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000207805", 
              "https://doi.org/10.1007/s10858-010-9424-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10858-010-9424-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000207805", 
              "https://doi.org/10.1007/s10858-010-9424-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1007988107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008697881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008900126", 
              "https://doi.org/10.1038/nsmb.1790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkl582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010422284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.00817-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010493979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0800256105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014826453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2008.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014826864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2008.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014826864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0079-6565(96)01028-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014964647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2011.01.049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017238212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017392719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10858-008-9288-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019767764", 
              "https://doi.org/10.1007/s10858-008-9288-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2009.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023661005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pnmrs.2008.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024108824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10858-006-9087-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025732001", 
              "https://doi.org/10.1007/s10858-006-9087-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pnmrs.2010.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026710137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(73)90182-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027256206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-440x(00)00087-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027317294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2364(84)90257-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028403092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028498447", 
              "https://doi.org/10.1038/nprot.2007.221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6565(97)00023-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029391671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(02)00153-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031443868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.20650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034321967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00197633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035644731", 
              "https://doi.org/10.1007/bf00197633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00197633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035644731", 
              "https://doi.org/10.1007/bf00197633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1003995107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036793077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0610313104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038680697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(92)81649-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038798518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1202692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040752755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmrb.1994.1021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041174234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2001.4987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043212796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043400608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1996.0855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043706774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045212970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2007.08.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045805284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2364(90)90305-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046412631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1194294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046843532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047665033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-11-231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048503968", 
              "https://doi.org/10.1186/1471-2105-11-231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.23.8785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048916212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-1280(81)85115-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049361212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00227472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051175236", 
              "https://doi.org/10.1007/bf00227472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00227472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051175236", 
              "https://doi.org/10.1007/bf00227472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00227472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051175236", 
              "https://doi.org/10.1007/bf00227472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018348123074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051753188", 
              "https://doi.org/10.1023/a:1018348123074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011914132531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051905524", 
              "https://doi.org/10.1023/a:1011914132531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-458x(200002)38:2<95::aid-mrc592>3.0.co;2-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052537649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-458x(200002)38:2<95::aid-mrc592>3.0.co;2-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052537649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053078774", 
              "https://doi.org/10.1038/nsmb986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053078774", 
              "https://doi.org/10.1038/nsmb986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053152333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07391102.1989.10507726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053494706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0033583500004169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053852242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0033583500004169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053852242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00023a002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055157610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00189a037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055164521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00440a039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055176244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi9607214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055211982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi9607214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055211982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi970122c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055213524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi970122c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055213524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja010033u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055760372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja010033u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055760372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja011646+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055776816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja011646+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055776816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja9528846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055863689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja9528846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055863689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja9902221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055871632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bk-1999-0732.ch014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1089355007"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-06", 
        "datePublishedReg": "2013-06-01", 
        "description": "We present a method for de novo derivation of the three-dimensional helix structure of nucleic acids using non-exchangeable proton chemical shifts as sole source of experimental restraints. The method is called chemical shift de novo structure derivation protocol employing singular value decomposition (CHEOPS) and uses iterative singular value decomposition to optimize the structure in helix parameter space. The correct performance of CHEOPS and its range of application are established via an extensive set of structure derivations using either simulated or experimental chemical shifts as input. The simulated input data are used to assess in a defined manner the effect of errors or limitations in the input data on the derived structures. We find that the RNA helix parameters can be determined with high accuracy. We finally demonstrate via three deposited RNA structures that experimental proton chemical shifts suffice to derive RNA helix structures with high precision and accuracy. CHEOPS provides, subject to further development, new directions for high-resolution NMR structure determination of nucleic acids.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10858-013-9725-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1101518", 
            "issn": [
              "0925-2738", 
              "1573-5001"
            ], 
            "name": "Journal of Biomolecular NMR", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "56"
          }
        ], 
        "name": "Nucleic acid helix structure determination from NMR proton chemical shifts", 
        "pagination": "95-112", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f64a84ac1f2a74445eb41f63e71f21a36c657311e5521b6e2564f1f2fa8182fb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23564038"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9110829"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10858-013-9725-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1051703904"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10858-013-9725-y", 
          "https://app.dimensions.ai/details/publication/pub.1051703904"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000491.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10858-013-9725-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10858-013-9725-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10858-013-9725-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10858-013-9725-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10858-013-9725-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    285 TRIPLES      21 PREDICATES      91 URIs      26 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10858-013-9725-y schema:about N3ac5bf620dbe483ca92763fb0c22c884
    2 N7a63bb29ce544d5798d5d44ccfed27cc
    3 N9b3dd6b207d643879892f457ac0e8c5c
    4 Nb08d0b86fbcc42b8b9ebe9dabc9af1c6
    5 Ne7a60f644dcd4deaab35961cf6117f8b
    6 anzsrc-for:03
    7 anzsrc-for:0307
    8 schema:author N6bf47ab524fe4759b023ac4b92f0db8f
    9 schema:citation sg:pub.10.1007/bf00197633
    10 sg:pub.10.1007/bf00227472
    11 sg:pub.10.1007/s10858-006-9087-9
    12 sg:pub.10.1007/s10858-008-9288-5
    13 sg:pub.10.1007/s10858-010-9424-x
    14 sg:pub.10.1023/a:1011914132531
    15 sg:pub.10.1023/a:1018348123074
    16 sg:pub.10.1038/nprot.2007.221
    17 sg:pub.10.1038/nsmb.1790
    18 sg:pub.10.1038/nsmb986
    19 sg:pub.10.1186/1471-2105-11-231
    20 https://doi.org/10.1002/(sici)1097-458x(200002)38:2<95::aid-mrc592>3.0.co;2-m
    21 https://doi.org/10.1002/bip.20650
    22 https://doi.org/10.1006/jmbi.1996.0855
    23 https://doi.org/10.1006/jmbi.2001.4987
    24 https://doi.org/10.1006/jmrb.1994.1021
    25 https://doi.org/10.1016/0022-2364(84)90257-9
    26 https://doi.org/10.1016/0022-2364(90)90305-s
    27 https://doi.org/10.1016/0022-2836(73)90182-4
    28 https://doi.org/10.1016/0079-6565(96)01028-x
    29 https://doi.org/10.1016/0166-1280(81)85115-9
    30 https://doi.org/10.1016/j.jmb.2007.08.033
    31 https://doi.org/10.1016/j.jmb.2011.01.049
    32 https://doi.org/10.1016/j.pnmrs.2008.06.002
    33 https://doi.org/10.1016/j.pnmrs.2010.01.002
    34 https://doi.org/10.1016/j.sbi.2009.07.015
    35 https://doi.org/10.1016/j.ymeth.2008.12.003
    36 https://doi.org/10.1016/s0006-3495(92)81649-1
    37 https://doi.org/10.1016/s0079-6565(97)00023-x
    38 https://doi.org/10.1016/s0959-440x(00)00087-7
    39 https://doi.org/10.1016/s1074-5521(02)00153-9
    40 https://doi.org/10.1017/s0033583500004169
    41 https://doi.org/10.1021/bi00023a002
    42 https://doi.org/10.1021/bi00189a037
    43 https://doi.org/10.1021/bi00440a039
    44 https://doi.org/10.1021/bi9607214
    45 https://doi.org/10.1021/bi970122c
    46 https://doi.org/10.1021/bk-1999-0732.ch014
    47 https://doi.org/10.1021/ja010033u
    48 https://doi.org/10.1021/ja011646+
    49 https://doi.org/10.1021/ja9528846
    50 https://doi.org/10.1021/ja9902221
    51 https://doi.org/10.1073/pnas.0610313104
    52 https://doi.org/10.1073/pnas.0800256105
    53 https://doi.org/10.1073/pnas.1003995107
    54 https://doi.org/10.1073/pnas.1007988107
    55 https://doi.org/10.1073/pnas.85.23.8785
    56 https://doi.org/10.1080/07391102.1989.10507726
    57 https://doi.org/10.1093/nar/gkg654
    58 https://doi.org/10.1093/nar/gkg680
    59 https://doi.org/10.1093/nar/gki704
    60 https://doi.org/10.1093/nar/gkl582
    61 https://doi.org/10.1093/nar/gkm774
    62 https://doi.org/10.1093/nar/gkn305
    63 https://doi.org/10.1126/science.1194294
    64 https://doi.org/10.1126/science.1202692
    65 https://doi.org/10.1128/aac.00817-09
    66 schema:datePublished 2013-06
    67 schema:datePublishedReg 2013-06-01
    68 schema:description We present a method for de novo derivation of the three-dimensional helix structure of nucleic acids using non-exchangeable proton chemical shifts as sole source of experimental restraints. The method is called chemical shift de novo structure derivation protocol employing singular value decomposition (CHEOPS) and uses iterative singular value decomposition to optimize the structure in helix parameter space. The correct performance of CHEOPS and its range of application are established via an extensive set of structure derivations using either simulated or experimental chemical shifts as input. The simulated input data are used to assess in a defined manner the effect of errors or limitations in the input data on the derived structures. We find that the RNA helix parameters can be determined with high accuracy. We finally demonstrate via three deposited RNA structures that experimental proton chemical shifts suffice to derive RNA helix structures with high precision and accuracy. CHEOPS provides, subject to further development, new directions for high-resolution NMR structure determination of nucleic acids.
    69 schema:genre research_article
    70 schema:inLanguage en
    71 schema:isAccessibleForFree false
    72 schema:isPartOf N76b38d46b71b4fa4bacdc729f1cbe9ae
    73 N7db87f9ee48045459d3fb4a8edafb0b8
    74 sg:journal.1101518
    75 schema:name Nucleic acid helix structure determination from NMR proton chemical shifts
    76 schema:pagination 95-112
    77 schema:productId N3d1dfa898f6b4fde8fea122aabcb10af
    78 N3fbe40f5d92e4c94b10f39653d127293
    79 N4ca2b2f915da460c8dd0ccc10f733e22
    80 Nb2eb7bb3e9f74686933e15ec5f400624
    81 Nc87e2136238e4c998907edc2ac1dbd5a
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051703904
    83 https://doi.org/10.1007/s10858-013-9725-y
    84 schema:sdDatePublished 2019-04-11T00:11
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher N8c5b473e13ce4cde9fb3f61c270e32ae
    87 schema:url http://link.springer.com/10.1007/s10858-013-9725-y
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N3ac5bf620dbe483ca92763fb0c22c884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name RNA
    93 rdf:type schema:DefinedTerm
    94 N3d1dfa898f6b4fde8fea122aabcb10af schema:name nlm_unique_id
    95 schema:value 9110829
    96 rdf:type schema:PropertyValue
    97 N3fbe40f5d92e4c94b10f39653d127293 schema:name pubmed_id
    98 schema:value 23564038
    99 rdf:type schema:PropertyValue
    100 N4ca2b2f915da460c8dd0ccc10f733e22 schema:name readcube_id
    101 schema:value f64a84ac1f2a74445eb41f63e71f21a36c657311e5521b6e2564f1f2fa8182fb
    102 rdf:type schema:PropertyValue
    103 N6bf47ab524fe4759b023ac4b92f0db8f rdf:first sg:person.01247472251.19
    104 rdf:rest Na29bb96b1fb445f6bf0a58cab602a6a7
    105 N7213466c7e2148cc8215cdac6ef4447e rdf:first sg:person.0672171122.04
    106 rdf:rest rdf:nil
    107 N76b38d46b71b4fa4bacdc729f1cbe9ae schema:volumeNumber 56
    108 rdf:type schema:PublicationVolume
    109 N7a63bb29ce544d5798d5d44ccfed27cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Nuclear Magnetic Resonance, Biomolecular
    111 rdf:type schema:DefinedTerm
    112 N7db87f9ee48045459d3fb4a8edafb0b8 schema:issueNumber 2
    113 rdf:type schema:PublicationIssue
    114 N8c5b473e13ce4cde9fb3f61c270e32ae schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N9b3dd6b207d643879892f457ac0e8c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Protons
    118 rdf:type schema:DefinedTerm
    119 Na29bb96b1fb445f6bf0a58cab602a6a7 rdf:first sg:person.01271277325.46
    120 rdf:rest N7213466c7e2148cc8215cdac6ef4447e
    121 Nb08d0b86fbcc42b8b9ebe9dabc9af1c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Nucleic Acid Conformation
    123 rdf:type schema:DefinedTerm
    124 Nb2eb7bb3e9f74686933e15ec5f400624 schema:name dimensions_id
    125 schema:value pub.1051703904
    126 rdf:type schema:PropertyValue
    127 Nc87e2136238e4c998907edc2ac1dbd5a schema:name doi
    128 schema:value 10.1007/s10858-013-9725-y
    129 rdf:type schema:PropertyValue
    130 Ne7a60f644dcd4deaab35961cf6117f8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Nucleic Acids
    132 rdf:type schema:DefinedTerm
    133 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Chemical Sciences
    135 rdf:type schema:DefinedTerm
    136 anzsrc-for:0307 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Theoretical and Computational Chemistry
    138 rdf:type schema:DefinedTerm
    139 sg:journal.1101518 schema:issn 0925-2738
    140 1573-5001
    141 schema:name Journal of Biomolecular NMR
    142 rdf:type schema:Periodical
    143 sg:person.01247472251.19 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
    144 schema:familyName van der Werf
    145 schema:givenName Ramon M.
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247472251.19
    147 rdf:type schema:Person
    148 sg:person.01271277325.46 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
    149 schema:familyName Tessari
    150 schema:givenName Marco
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271277325.46
    152 rdf:type schema:Person
    153 sg:person.0672171122.04 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
    154 schema:familyName Wijmenga
    155 schema:givenName Sybren S.
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672171122.04
    157 rdf:type schema:Person
    158 sg:pub.10.1007/bf00197633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035644731
    159 https://doi.org/10.1007/bf00197633
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/bf00227472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051175236
    162 https://doi.org/10.1007/bf00227472
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s10858-006-9087-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025732001
    165 https://doi.org/10.1007/s10858-006-9087-9
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s10858-008-9288-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019767764
    168 https://doi.org/10.1007/s10858-008-9288-5
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1007/s10858-010-9424-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000207805
    171 https://doi.org/10.1007/s10858-010-9424-x
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1023/a:1011914132531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051905524
    174 https://doi.org/10.1023/a:1011914132531
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1023/a:1018348123074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051753188
    177 https://doi.org/10.1023/a:1018348123074
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/nprot.2007.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028498447
    180 https://doi.org/10.1038/nprot.2007.221
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/nsmb.1790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008900126
    183 https://doi.org/10.1038/nsmb.1790
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/nsmb986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053078774
    186 https://doi.org/10.1038/nsmb986
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1186/1471-2105-11-231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048503968
    189 https://doi.org/10.1186/1471-2105-11-231
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1002/(sici)1097-458x(200002)38:2<95::aid-mrc592>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1052537649
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1002/bip.20650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034321967
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1006/jmbi.1996.0855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043706774
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1006/jmbi.2001.4987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043212796
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1006/jmrb.1994.1021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041174234
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/0022-2364(84)90257-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028403092
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/0022-2364(90)90305-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1046412631
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/0022-2836(73)90182-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027256206
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/0079-6565(96)01028-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014964647
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/0166-1280(81)85115-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049361212
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.jmb.2007.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045805284
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.jmb.2011.01.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017238212
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.pnmrs.2008.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024108824
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/j.pnmrs.2010.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026710137
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/j.sbi.2009.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023661005
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.ymeth.2008.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014826864
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/s0006-3495(92)81649-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038798518
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/s0079-6565(97)00023-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029391671
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/s0959-440x(00)00087-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027317294
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/s1074-5521(02)00153-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031443868
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1017/s0033583500004169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053852242
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1021/bi00023a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157610
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1021/bi00189a037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055164521
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1021/bi00440a039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055176244
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1021/bi9607214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055211982
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1021/bi970122c schema:sameAs https://app.dimensions.ai/details/publication/pub.1055213524
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1021/bk-1999-0732.ch014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089355007
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1021/ja010033u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055760372
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1021/ja011646+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1055776816
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1021/ja9528846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055863689
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1021/ja9902221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055871632
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1073/pnas.0610313104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038680697
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1073/pnas.0800256105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014826453
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1073/pnas.1003995107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036793077
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1073/pnas.1007988107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008697881
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1073/pnas.85.23.8785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048916212
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1080/07391102.1989.10507726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053494706
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1093/nar/gkg654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053152333
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1093/nar/gkg680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045212970
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/nar/gki704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043400608
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1093/nar/gkl582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010422284
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1093/nar/gkm774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017392719
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1093/nar/gkn305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047665033
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1126/science.1194294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046843532
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1126/science.1202692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040752755
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1128/aac.00817-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010493979
    282 rdf:type schema:CreativeWork
    283 https://www.grid.ac/institutes/grid.5590.9 schema:alternateName Radboud University Nijmegen
    284 schema:name Department of Biophysical Chemistry, Institute of Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
    285 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...