A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Reza M. Salek, Michael R. Pears, Jonathan D. Cooper, Hannah M. Mitchison, David A. Pearce, Russell J. Mortishire-Smith, Julian L. Griffin

ABSTRACT

The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in γ-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models. More... »

PAGES

175-184

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10858-011-9491-7

DOI

http://dx.doi.org/10.1007/s10858-011-9491-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043048967

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21461951


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuronal Ceroid-Lipofuscinoses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pigments, Biological", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salek", 
        "givenName": "Reza M.", 
        "id": "sg:person.01344720244.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344720244.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pears", 
        "givenName": "Michael R.", 
        "id": "sg:person.01051441772.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051441772.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooper", 
        "givenName": "Jonathan D.", 
        "id": "sg:person.01013630246.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013630246.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Paediatrics and Child Health, Royal Free and University College Medical School, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchison", 
        "givenName": "Hannah M.", 
        "id": "sg:person.01314407267.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314407267.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of South Dakota", 
          "id": "https://www.grid.ac/institutes/grid.267169.d", 
          "name": [
            "Department of Pediatrics, Sanford School of Medicine of the University of South Dakota, 2301 East 60th Street North, 57104-0589, Sioux Falls, SD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pearce", 
        "givenName": "David A.", 
        "id": "sg:person.01344603457.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344603457.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Belgium)", 
          "id": "https://www.grid.ac/institutes/grid.419619.2", 
          "name": [
            "Johnson & Johnson PR & D, Turnhoutsweg 30, 2340, Beerse, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mortishire-Smith", 
        "givenName": "Russell J.", 
        "id": "sg:person.0765706037.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765706037.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK", 
            "Department of Biochemistry, University of Cambridge, Building O, Downing Site, Tennis Court Road, CB2 1QW, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffin", 
        "givenName": "Julian L.", 
        "id": "sg:person.012451221647.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451221647.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0066-4103(08)60035-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003422066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0278-5846(03)00078-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005469784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0278-5846(03)00078-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005469784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2004.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005646462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e03-02-0120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007656833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.1998.tb00142.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007925423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/11.12.1421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008908265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/10.19.2123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011381943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011665238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011665238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nbdi.1999.0267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016721108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2004.tb00502.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017214787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1996.0410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018602157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejpn.2000.0450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021342225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2010.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022005717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2003.01602.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022046493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023612837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-007-9542-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026042754", 
          "https://doi.org/10.1007/s11064-007-9542-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/7.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028682957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(78)90229-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029085959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(78)90229-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029085959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030648036", 
          "https://doi.org/10.1038/13868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030648036", 
          "https://doi.org/10.1038/13868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019052-200304000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031458958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019052-200304000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031458958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m507380200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031576895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m507380200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031576895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032265127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034450580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01111932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039883129", 
          "https://doi.org/10.1007/bf01111932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01111932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039883129", 
          "https://doi.org/10.1007/bf01111932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cem.695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041284614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00456.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041571251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042074284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2136651100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042997044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00100.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043055340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2364(81)90037-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044536613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.2008.00984.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048742401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2004.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049328643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8628(19980526)77:4<289::aid-ajmg8>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049604508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awf180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050712608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1528-1157.2002.38901.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052354903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053126853", 
          "https://doi.org/10.1038/8861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053126853", 
          "https://doi.org/10.1038/8861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4547(19990815)57:4<551::aid-jnr15>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053600518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/338708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058637942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-07-02556.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074268114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082662836", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082679648", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1107758944", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471725331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107758944"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-04", 
    "datePublishedReg": "2011-04-01", 
    "description": "The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in \u03b3-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6\u00a0month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2\u00a0months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10858-011-9491-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2609157", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2617356", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1101518", 
        "issn": [
          "0925-2738", 
          "1573-5001"
        ], 
        "name": "Journal of Biomolecular NMR", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3-4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "name": "A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses", 
    "pagination": "175-184", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cd0e8a2b9747229acbeeaa75648d2ed62d4d71f31391643abb25d8512fa29464"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21461951"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9110829"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10858-011-9491-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043048967"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10858-011-9491-7", 
      "https://app.dimensions.ai/details/publication/pub.1043048967"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000593.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10858-011-9491-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10858-011-9491-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10858-011-9491-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10858-011-9491-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10858-011-9491-7'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      83 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10858-011-9491-7 schema:about N4eca0553d20d4ae38f3769603c22e1e7
2 N531040fcc9344d79916815d7f3ca5a11
3 N5d7878228ef1498da814e1bca31f2093
4 N6ba78e15a7a84da5b52a48acc8a6cd7f
5 N87a1f95f08d84bf28382d45d13d2be17
6 N8af235ea47d54faf93eca31569d8a0da
7 N8d684a4e49f24be9b84ef1131eee1f25
8 N9cf479c09f94447fa28ff2eac6d42c5d
9 Nbb55440ad0fd45fd9f93a3fe1cd9dc05
10 Nc683b7384617458bad37d111ef600bd5
11 Ne4e196630e2f4de596549ee82d1c1bfb
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N5a801e2119d04f5daef4c24c7abf14bc
15 schema:citation sg:pub.10.1007/bf01111932
16 sg:pub.10.1007/s11064-007-9542-3
17 sg:pub.10.1038/13868
18 sg:pub.10.1038/8861
19 https://app.dimensions.ai/details/publication/pub.1082662836
20 https://app.dimensions.ai/details/publication/pub.1082679648
21 https://app.dimensions.ai/details/publication/pub.1107758944
22 https://doi.org/10.1002/(sici)1096-8628(19980526)77:4<289::aid-ajmg8>3.0.co;2-i
23 https://doi.org/10.1002/(sici)1097-4547(19990815)57:4<551::aid-jnr15>3.0.co;2-r
24 https://doi.org/10.1002/0471725331
25 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v
26 https://doi.org/10.1002/cem.695
27 https://doi.org/10.1002/nbm.740
28 https://doi.org/10.1006/geno.1996.0410
29 https://doi.org/10.1006/nbdi.1999.0267
30 https://doi.org/10.1016/0022-2364(81)90037-8
31 https://doi.org/10.1016/0022-510x(78)90229-0
32 https://doi.org/10.1016/j.brainres.2004.07.030
33 https://doi.org/10.1016/j.nbd.2004.02.010
34 https://doi.org/10.1016/j.neuint.2010.04.001
35 https://doi.org/10.1016/s0066-4103(08)60035-6
36 https://doi.org/10.1016/s0278-5846(03)00078-2
37 https://doi.org/10.1046/j.1471-4159.2001.00456.x
38 https://doi.org/10.1046/j.1471-4159.2003.01602.x
39 https://doi.org/10.1046/j.1528-1157.2002.38901.x
40 https://doi.org/10.1053/ejpn.2000.0450
41 https://doi.org/10.1073/pnas.2136651100
42 https://doi.org/10.1074/jbc.m507380200
43 https://doi.org/10.1086/338708
44 https://doi.org/10.1091/mbc.e03-02-0120
45 https://doi.org/10.1093/brain/awf180
46 https://doi.org/10.1093/hmg/10.19.2123
47 https://doi.org/10.1093/hmg/11.12.1421
48 https://doi.org/10.1093/hmg/7.1.85
49 https://doi.org/10.1093/hmg/ddh321
50 https://doi.org/10.1093/hmg/ddi406
51 https://doi.org/10.1097/00019052-200304000-00001
52 https://doi.org/10.1111/j.1365-2990.2008.00984.x
53 https://doi.org/10.1111/j.1750-3639.1998.tb00142.x
54 https://doi.org/10.1111/j.1750-3639.2004.tb00502.x
55 https://doi.org/10.1152/physiolgenomics.00100.2002
56 https://doi.org/10.1242/jcs.02656
57 https://doi.org/10.1523/jneurosci.19-07-02556.1999
58 schema:datePublished 2011-04
59 schema:datePublishedReg 2011-04-01
60 schema:description The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in γ-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf Na8dced29845c46a4af00f35bf1574f77
65 Ne755f93f425641968e98d49f73f3e39f
66 sg:journal.1101518
67 schema:name A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses
68 schema:pagination 175-184
69 schema:productId N504196430f30494ca3f73e7f7205a5a2
70 N53d51a6316034f42849e1c684db0c213
71 N61891fac9625441f8b75e7ec900273a2
72 N81982499c1fe4d0b87a87de5ae2989a9
73 N97eafecb4c6d4715be67d6124069c2a1
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043048967
75 https://doi.org/10.1007/s10858-011-9491-7
76 schema:sdDatePublished 2019-04-10T14:22
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N4eee4101b0b249e1920e81a7284637d1
79 schema:url http://link.springer.com/10.1007/s10858-011-9491-7
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N4eca0553d20d4ae38f3769603c22e1e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Pigments, Biological
85 rdf:type schema:DefinedTerm
86 N4eee4101b0b249e1920e81a7284637d1 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N504196430f30494ca3f73e7f7205a5a2 schema:name dimensions_id
89 schema:value pub.1043048967
90 rdf:type schema:PropertyValue
91 N531040fcc9344d79916815d7f3ca5a11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Neurons
93 rdf:type schema:DefinedTerm
94 N53d51a6316034f42849e1c684db0c213 schema:name pubmed_id
95 schema:value 21461951
96 rdf:type schema:PropertyValue
97 N5a801e2119d04f5daef4c24c7abf14bc rdf:first sg:person.01344720244.70
98 rdf:rest Nb19f8498230042eb884df14e54f1b130
99 N5d7878228ef1498da814e1bca31f2093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cerebellum
101 rdf:type schema:DefinedTerm
102 N61891fac9625441f8b75e7ec900273a2 schema:name readcube_id
103 schema:value cd0e8a2b9747229acbeeaa75648d2ed62d4d71f31391643abb25d8512fa29464
104 rdf:type schema:PropertyValue
105 N6ba78e15a7a84da5b52a48acc8a6cd7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Glutamic Acid
107 rdf:type schema:DefinedTerm
108 N81982499c1fe4d0b87a87de5ae2989a9 schema:name nlm_unique_id
109 schema:value 9110829
110 rdf:type schema:PropertyValue
111 N87a1f95f08d84bf28382d45d13d2be17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cerebral Cortex
113 rdf:type schema:DefinedTerm
114 N8af235ea47d54faf93eca31569d8a0da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Glutamine
116 rdf:type schema:DefinedTerm
117 N8d684a4e49f24be9b84ef1131eee1f25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Magnetic Resonance Spectroscopy
119 rdf:type schema:DefinedTerm
120 N97eafecb4c6d4715be67d6124069c2a1 schema:name doi
121 schema:value 10.1007/s10858-011-9491-7
122 rdf:type schema:PropertyValue
123 N9cf479c09f94447fa28ff2eac6d42c5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice
125 rdf:type schema:DefinedTerm
126 Na8dced29845c46a4af00f35bf1574f77 schema:issueNumber 3-4
127 rdf:type schema:PublicationIssue
128 Nb19f8498230042eb884df14e54f1b130 rdf:first sg:person.01051441772.22
129 rdf:rest Nbe830e79d9fb49fe8ae85c57be1012f9
130 Nb3a82aa7183c4cd793132a6b57bfe9d5 rdf:first sg:person.012451221647.25
131 rdf:rest rdf:nil
132 Nbb55440ad0fd45fd9f93a3fe1cd9dc05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Disease Models, Animal
134 rdf:type schema:DefinedTerm
135 Nbe4ddbc5409646e7b3b44a518ed85da1 rdf:first sg:person.01344603457.72
136 rdf:rest Ne717be8d8d644f1e8dca2b4d576dac89
137 Nbe830e79d9fb49fe8ae85c57be1012f9 rdf:first sg:person.01013630246.83
138 rdf:rest Ned411cfc6b10425f99e5111cf6732f51
139 Nc683b7384617458bad37d111ef600bd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 Ne4e196630e2f4de596549ee82d1c1bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neuronal Ceroid-Lipofuscinoses
144 rdf:type schema:DefinedTerm
145 Ne717be8d8d644f1e8dca2b4d576dac89 rdf:first sg:person.0765706037.35
146 rdf:rest Nb3a82aa7183c4cd793132a6b57bfe9d5
147 Ne755f93f425641968e98d49f73f3e39f schema:volumeNumber 49
148 rdf:type schema:PublicationVolume
149 Ned411cfc6b10425f99e5111cf6732f51 rdf:first sg:person.01314407267.43
150 rdf:rest Nbe4ddbc5409646e7b3b44a518ed85da1
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
155 schema:name Neurosciences
156 rdf:type schema:DefinedTerm
157 sg:grant.2609157 http://pending.schema.org/fundedItem sg:pub.10.1007/s10858-011-9491-7
158 rdf:type schema:MonetaryGrant
159 sg:grant.2617356 http://pending.schema.org/fundedItem sg:pub.10.1007/s10858-011-9491-7
160 rdf:type schema:MonetaryGrant
161 sg:journal.1101518 schema:issn 0925-2738
162 1573-5001
163 schema:name Journal of Biomolecular NMR
164 rdf:type schema:Periodical
165 sg:person.01013630246.83 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
166 schema:familyName Cooper
167 schema:givenName Jonathan D.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013630246.83
169 rdf:type schema:Person
170 sg:person.01051441772.22 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
171 schema:familyName Pears
172 schema:givenName Michael R.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051441772.22
174 rdf:type schema:Person
175 sg:person.012451221647.25 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
176 schema:familyName Griffin
177 schema:givenName Julian L.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451221647.25
179 rdf:type schema:Person
180 sg:person.01314407267.43 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
181 schema:familyName Mitchison
182 schema:givenName Hannah M.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314407267.43
184 rdf:type schema:Person
185 sg:person.01344603457.72 schema:affiliation https://www.grid.ac/institutes/grid.267169.d
186 schema:familyName Pearce
187 schema:givenName David A.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344603457.72
189 rdf:type schema:Person
190 sg:person.01344720244.70 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
191 schema:familyName Salek
192 schema:givenName Reza M.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344720244.70
194 rdf:type schema:Person
195 sg:person.0765706037.35 schema:affiliation https://www.grid.ac/institutes/grid.419619.2
196 schema:familyName Mortishire-Smith
197 schema:givenName Russell J.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765706037.35
199 rdf:type schema:Person
200 sg:pub.10.1007/bf01111932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039883129
201 https://doi.org/10.1007/bf01111932
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s11064-007-9542-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026042754
204 https://doi.org/10.1007/s11064-007-9542-3
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/13868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030648036
207 https://doi.org/10.1038/13868
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/8861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053126853
210 https://doi.org/10.1038/8861
211 rdf:type schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082662836 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082679648 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1107758944 schema:CreativeWork
215 https://doi.org/10.1002/(sici)1096-8628(19980526)77:4<289::aid-ajmg8>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1049604508
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/(sici)1097-4547(19990815)57:4<551::aid-jnr15>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1053600518
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/0471725331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107758944
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1032265127
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/cem.695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041284614
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/nbm.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023612837
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1006/geno.1996.0410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018602157
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1006/nbdi.1999.0267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016721108
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0022-2364(81)90037-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044536613
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0022-510x(78)90229-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029085959
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.brainres.2004.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005646462
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.nbd.2004.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049328643
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.neuint.2010.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022005717
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0066-4103(08)60035-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003422066
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0278-5846(03)00078-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005469784
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1046/j.1471-4159.2001.00456.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041571251
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1046/j.1471-4159.2003.01602.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022046493
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1046/j.1528-1157.2002.38901.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052354903
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1053/ejpn.2000.0450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021342225
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1073/pnas.2136651100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042997044
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1074/jbc.m507380200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031576895
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1086/338708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058637942
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1091/mbc.e03-02-0120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007656833
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/brain/awf180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050712608
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/hmg/10.19.2123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011381943
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/hmg/11.12.1421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008908265
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/hmg/7.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028682957
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/hmg/ddh321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042074284
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/hmg/ddi406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011665238
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00019052-200304000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031458958
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1365-2990.2008.00984.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048742401
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1750-3639.1998.tb00142.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007925423
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1750-3639.2004.tb00502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017214787
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1152/physiolgenomics.00100.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043055340
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1242/jcs.02656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034450580
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1523/jneurosci.19-07-02556.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074268114
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
288 schema:name Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry, King’s College London, London, UK
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.267169.d schema:alternateName University of South Dakota
291 schema:name Department of Pediatrics, Sanford School of Medicine of the University of South Dakota, 2301 East 60th Street North, 57104-0589, Sioux Falls, SD, USA
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.419619.2 schema:alternateName Janssen (Belgium)
294 schema:name Johnson & Johnson PR & D, Turnhoutsweg 30, 2340, Beerse, Belgium
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
297 schema:name Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
298 Department of Biochemistry, University of Cambridge, Building O, Downing Site, Tennis Court Road, CB2 1QW, Cambridge, UK
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
301 schema:name Department of Paediatrics and Child Health, Royal Free and University College Medical School, London, UK
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...