Synthesis and characterization of PLGA/HAP scaffolds with DNA-functionalised calcium phosphate nanoparticles for bone tissue engineering View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-02

AUTHORS

Viktoriya Sokolova, Kathrin Kostka, K. T. Shalumon, Oleg Prymak, Jyh-Ping Chen, Matthias Epple

ABSTRACT

Porous scaffolds of poly(lactide-co-glycolide) (PLGA; 85:15) and nano-hydroxyapatite (nHAP) were prepared by an emulsion-precipitation procedure from uniform PLGA–nHAP spheres (150–250 µm diameter). These spheres were then thermally sintered at 83 °C to porous scaffolds that can serve for bone tissue engineering or for bone substitution. The base materials PLGA and nHAP and the PLGA–nHAP scaffolds were extensively characterized by X-ray powder diffraction, infrared spectroscopy, thermogravimetry, differential scanning calorimetry, and scanning electron microscopy. The scaffold porosity was about 50 vol% as determined by relating mass and volume of the scaffolds, together with the computed density of the solid phase (PLGA–nHAP). The cultivation of HeLa cells demonstrated their high cytocompatibility. In combination with DNA-loaded calcium phosphate nanoparticles, they showed a good activity of gene transfection with enhanced green fluorescent protein (EGFP) as model protein. This is expected enhance bone growth around an implanted scaffold or inside a scaffold for tissue engineering. More... »

PAGES

102

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-020-06442-1

DOI

http://dx.doi.org/10.1007/s10856-020-06442-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132265037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33140175


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