Ontology type: schema:ScholarlyArticle
2019-03-06
AUTHORSShirin Toosi, Hojjat Naderi-Meshkin, Fatemeh Kalalinia, Hossein HosseinKhani, Asieh Heirani-Tabasi, Shahrzad Havakhah, Sirous Nekooei, Amir Hossein Jafarian, Fahimeh Rezaie, Mohammad Taghi Peivandi, Hooman Mesgarani, Javad Behravan
ABSTRACTWe have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1 × 106 cells per each defect); (3) AD-MSCs (1 × 106 cells) no scaffold material, and (4) blank control. The rabbits were then divided into 3 random groups (of 5) and the treatment outcomes were evaluated at 4, 8 and 12 weeks. New bone formation was histologically assessed. Experimental groups were analyzed by CT scan and real-time PCR. Histological analysis of bone defects treated with collagen/PGA alone exhibited significant fibrous connective tissue formation at the 12 weeks of treatments (P ≤ 0.05). There was no significant difference between collagen/PGA alone and collagen/PGA + AD-MSCs groups. The results were confirmed by CT scan data showing healing percentages of 34.20% for the collage/PGA group alone as compared to the control group and no difference with collagen/PGA containing AD-MSCs (1 × 106 cells). RT-PCR analysis also indicated no significant differences between collagen/PGA and collagen/PGA + AD-MSC groups, although both scaffold containing groups significantly express ALP and SIO rather than groups without scaffolds. Although there was no significant difference between the scaffolds containing cells with non-cellular scaffolds, our results indicated that the Collagen/PGA scaffold itself had a significant effect on wound healing as compared to the control group. Therefore, the collagen/PGA scaffold seems to be a promising candidate for research in bone regeneration. More... »
PAGES33
http://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9
DOIhttp://dx.doi.org/10.1007/s10856-019-6235-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112584665
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30840143
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biomedical Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Materials Engineering",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adipose Tissue",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biocompatible Materials",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Regeneration",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone and Bones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Lineage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chondrocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Collagen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fibroblasts",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fracture Healing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mesenchymal Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mesenchymal Stem Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyglycolic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabbits",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Real-Time Polymerase Chain Reaction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Engineering",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Scaffolds",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tomography, X-Ray Computed",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Wound Healing",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "NanoSBY Knowledge Based Corporation, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran",
"NanoSBY Knowledge Based Corporation, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Toosi",
"givenName": "Shirin",
"id": "sg:person.014212754751.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014212754751.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/None",
"name": [
"NanoSBY Knowledge Based Corporation, Mashhad, Iran",
"Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Naderi-Meshkin",
"givenName": "Hojjat",
"id": "sg:person.0715547640.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715547640.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411583.a",
"name": [
"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Kalalinia",
"givenName": "Fatemeh",
"id": "sg:person.01354672317.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354672317.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Innovation Center for Advanced Technology, Matrix, Inc., 10029, New York, NY, USA",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Innovation Center for Advanced Technology, Matrix, Inc., 10029, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "HosseinKhani",
"givenName": "Hossein",
"id": "sg:person.0773173167.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773173167.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Heirani-Tabasi",
"givenName": "Asieh",
"id": "sg:person.01335211077.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335211077.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Physiology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411583.a",
"name": [
"Physiology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Havakhah",
"givenName": "Shahrzad",
"id": "sg:person.01215566662.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215566662.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411583.a",
"name": [
"Department of Radiology, Mashhad University of Medical Sciences, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Nekooei",
"givenName": "Sirous",
"id": "sg:person.0764104025.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764104025.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411583.a",
"name": [
"Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Jafarian",
"givenName": "Amir Hossein",
"id": "sg:person.01153230256.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153230256.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Stem Cells and Regenerative Medicine Research Group, Academic Center for Education Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Rezaie",
"givenName": "Fahimeh",
"id": "sg:person.013054224323.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013054224323.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Orthopedic Surgery, Orthopedic and Trauma Research Center, Mashhad University of Medical Sciences, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411583.a",
"name": [
"Department of Orthopedic Surgery, Orthopedic and Trauma Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Peivandi",
"givenName": "Mohammad Taghi",
"id": "sg:person.01313075313.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313075313.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Veterinary Sciences, Ferdowsi University of Mashhad, Mashhad, Iran",
"id": "http://www.grid.ac/institutes/grid.411301.6",
"name": [
"Department of Veterinary Sciences, Ferdowsi University of Mashhad, Mashhad, Iran"
],
"type": "Organization"
},
"familyName": "Mesgarani",
"givenName": "Hooman",
"id": "sg:person.013755475425.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013755475425.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for Bioengineering and Biotechnology, University of Waterloo, Waterloo, ON, Canada",
"id": "http://www.grid.ac/institutes/grid.46078.3d",
"name": [
"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran",
"NanoSBY Knowledge Based Corporation, Mashhad, Iran",
"School of Pharmacy, University of Waterloo, Waterloo, ON, Canada",
"Center for Bioengineering and Biotechnology, University of Waterloo, Waterloo, ON, Canada"
],
"type": "Organization"
},
"familyName": "Behravan",
"givenName": "Javad",
"id": "sg:person.01245756105.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245756105.18"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00701-006-0740-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024211500",
"https://doi.org/10.1007/s00701-006-0740-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/b99997",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026994380",
"https://doi.org/10.1007/b99997"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-94-010-0305-6_14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025410380",
"https://doi.org/10.1007/978-94-010-0305-6_14"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/b:abme.0000017544.36001.8e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040671954",
"https://doi.org/10.1023/b:abme.0000017544.36001.8e"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt958",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032078985",
"https://doi.org/10.1038/nbt958"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302386",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040271001",
"https://doi.org/10.1038/sj.gt.3302386"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00119733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009958200",
"https://doi.org/10.1007/bf00119733"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-03-06",
"datePublishedReg": "2019-03-06",
"description": "We have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1\u2009\u00d7\u2009106 cells per each defect); (3) AD-MSCs (1\u2009\u00d7\u2009106 cells) no scaffold material, and (4) blank control. The rabbits were then divided into 3 random groups (of 5) and the treatment outcomes were evaluated at 4, 8 and 12 weeks. New bone formation was histologically assessed. Experimental groups were analyzed by CT scan and real-time PCR. Histological analysis of bone defects treated with collagen/PGA alone exhibited significant fibrous connective tissue formation at the 12 weeks of treatments (P\u2009\u2264\u20090.05). There was no significant difference between collagen/PGA alone and collagen/PGA\u2009+\u2009AD-MSCs groups. The results were confirmed by CT scan data showing healing percentages of 34.20% for the collage/PGA group alone as compared to the control group and no difference with collagen/PGA containing AD-MSCs (1\u2009\u00d7\u2009106 cells). RT-PCR analysis also indicated no significant differences between collagen/PGA and collagen/PGA\u2009+\u2009AD-MSC groups, although both scaffold containing groups significantly express ALP and SIO rather than groups without scaffolds. Although there was no significant difference between the scaffolds containing cells with non-cellular scaffolds, our results indicated that the Collagen/PGA scaffold itself had a significant effect on wound healing as compared to the control group. Therefore, the collagen/PGA scaffold seems to be a promising candidate for research in bone regeneration.",
"genre": "article",
"id": "sg:pub.10.1007/s10856-019-6235-9",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1100668",
"issn": [
"0957-4530",
"1573-4838"
],
"name": "Journal of Materials Science: Materials in Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "30"
}
],
"keywords": [
"AD-MSC group",
"control group",
"significant differences",
"weeks of treatment",
"adipose-derived mesenchymal stem cells",
"critical size defects",
"bone defects",
"fibrous connective tissue formation",
"treatment modalities",
"new bone formation",
"treatment outcomes",
"real-time PCR",
"connective tissue formation",
"Ad-MSCs",
"mesenchymal stem cells",
"bone defect healing",
"histological analysis",
"PGA group",
"RT-PCR analysis",
"bone formation",
"healing percentage",
"wound healing",
"calvarial bone",
"experimental group",
"rabbits",
"blank control",
"stem cells",
"CT scan data",
"weeks",
"calvarial bone defects",
"healing",
"random group",
"tissue formation",
"group",
"defect healing",
"polyglycolic acid",
"bone regeneration",
"size defects",
"cells",
"PGA scaffolds",
"differences",
"CT",
"significant effect",
"outcomes",
"defects",
"modalities",
"treatment",
"bone",
"glycolic acid scaffolds",
"regeneration",
"PCR",
"bone critical size defects",
"acid scaffolds",
"percentage",
"scan data",
"control",
"PGA",
"effect",
"analysis",
"results",
"acid",
"candidates",
"scaffolds",
"scaffold material",
"promising candidate",
"data",
"formation",
"research",
"materials",
"Alps",
"capability",
"SiO"
],
"name": "Bone defect healing is induced by collagen sponge/polyglycolic acid",
"pagination": "33",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112584665"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10856-019-6235-9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30840143"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10856-019-6235-9",
"https://app.dimensions.ai/details/publication/pub.1112584665"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_805.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10856-019-6235-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9'
This table displays all metadata directly associated to this object as RDF triples.
352 TRIPLES
22 PREDICATES
127 URIs
111 LITERALS
28 BLANK NODES