Bone defect healing is induced by collagen sponge/polyglycolic acid View Full Text


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Article Info

DATE

2019-03-06

AUTHORS

Shirin Toosi, Hojjat Naderi-Meshkin, Fatemeh Kalalinia, Hossein HosseinKhani, Asieh Heirani-Tabasi, Shahrzad Havakhah, Sirous Nekooei, Amir Hossein Jafarian, Fahimeh Rezaie, Mohammad Taghi Peivandi, Hooman Mesgarani, Javad Behravan

ABSTRACT

We have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1 × 106 cells per each defect); (3) AD-MSCs (1 × 106 cells) no scaffold material, and (4) blank control. The rabbits were then divided into 3 random groups (of 5) and the treatment outcomes were evaluated at 4, 8 and 12 weeks. New bone formation was histologically assessed. Experimental groups were analyzed by CT scan and real-time PCR. Histological analysis of bone defects treated with collagen/PGA alone exhibited significant fibrous connective tissue formation at the 12 weeks of treatments (P ≤ 0.05). There was no significant difference between collagen/PGA alone and collagen/PGA + AD-MSCs groups. The results were confirmed by CT scan data showing healing percentages of 34.20% for the collage/PGA group alone as compared to the control group and no difference with collagen/PGA containing AD-MSCs (1 × 106 cells). RT-PCR analysis also indicated no significant differences between collagen/PGA and collagen/PGA + AD-MSC groups, although both scaffold containing groups significantly express ALP and SIO rather than groups without scaffolds. Although there was no significant difference between the scaffolds containing cells with non-cellular scaffolds, our results indicated that the Collagen/PGA scaffold itself had a significant effect on wound healing as compared to the control group. Therefore, the collagen/PGA scaffold seems to be a promising candidate for research in bone regeneration. More... »

PAGES

33

References to SciGraph publications

  • 2004-10-28. Sonic hedgehog gene-enhanced tissue engineering for bone regeneration in GENE THERAPY
  • 2004-04-11. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects in NATURE BIOTECHNOLOGY
  • 2006-02-09. Analyses of the factors influencing bone graft infection after delayed cranioplasty in ACTA NEUROCHIRURGICA
  • 2005-03-07. Tissue Engineering Strategies for Bone Regeneration in REGENERATIVE MEDICINE II
  • 2002. Bone Tissue Engineering by Cell Transplantation in POLYMER BASED SYSTEMS ON TISSUE ENGINEERING, REPLACEMENT AND REGENERATION
  • 1996-04. Evaluation of different chemical methods for cros-linking collagen gel, films and sponges in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 2004-03. Polymeric Scaffolds for Bone Tissue Engineering in ANNALS OF BIOMEDICAL ENGINEERING
  • Journal

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10856-019-6235-9

    DOI

    http://dx.doi.org/10.1007/s10856-019-6235-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112584665

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30840143


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    35 schema:description We have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1 × 106 cells per each defect); (3) AD-MSCs (1 × 106 cells) no scaffold material, and (4) blank control. The rabbits were then divided into 3 random groups (of 5) and the treatment outcomes were evaluated at 4, 8 and 12 weeks. New bone formation was histologically assessed. Experimental groups were analyzed by CT scan and real-time PCR. Histological analysis of bone defects treated with collagen/PGA alone exhibited significant fibrous connective tissue formation at the 12 weeks of treatments (P ≤ 0.05). There was no significant difference between collagen/PGA alone and collagen/PGA + AD-MSCs groups. The results were confirmed by CT scan data showing healing percentages of 34.20% for the collage/PGA group alone as compared to the control group and no difference with collagen/PGA containing AD-MSCs (1 × 106 cells). RT-PCR analysis also indicated no significant differences between collagen/PGA and collagen/PGA + AD-MSC groups, although both scaffold containing groups significantly express ALP and SIO rather than groups without scaffolds. Although there was no significant difference between the scaffolds containing cells with non-cellular scaffolds, our results indicated that the Collagen/PGA scaffold itself had a significant effect on wound healing as compared to the control group. Therefore, the collagen/PGA scaffold seems to be a promising candidate for research in bone regeneration.
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