Cytocompatibility of the selected calcium phosphate based bone cements: comparative study in human cell culture View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-28

AUTHORS

Radosław Olkowski, Piotr Kaszczewski, Joanna Czechowska, Dominika Siek, Dawid Pijocha, Aneta Zima, Anna Ślósarczyk, Małgorzata Lewandowska-Szumieł

ABSTRACT

Calcium phosphate cements (CPC) are valuable bone fillers. Recently they have been also considered as the basis for drug-, growth factors- or cells-delivery systems. Broad possibilities to manipulate CPC composition provide a unique opportunity to obtain materials with a wide range of physicochemical properties. In this study we show that CPC composition significantly influences cell response. Human bone derived cells were exposed to the several well-characterized different cements based on calcium phosphates, magnesium phosphates and calcium sulfate hemihydrate (CSH). Cell viability assays, live/dead staining and real-time observation of cells in contact with the materials (time-laps) were performed. Although all the investigated materials have successfully passed a standard cytocompatibility assay, cell behavior in a direct contact with the materials varied depending on the material and the experimental system. The most recommended were the α-TCP-based materials which proved suitable as a support for cells in a direct contact. The materials which caused a decrease of calcium ions concentration in culture induced the negative cell response, however this effect might be expected efficiently compensated in vivo. All the materials consisting of CSH had negative impact on the cells. The obtained results strongly support running series of cytocompatibility studies for preclinical evaluation of bone cements. More... »

PAGES

270

References to SciGraph publications

  • 1996-04-18. Isolation and Culture of Bone-Forming Cells (Osteoblasts) from Human Bone in HUMAN CELL CULTURE PROTOCOLS
  • 2005-03. Osteogenic cell contact with biomaterials influences phenotype expression in CELL AND TISSUE BANKING
  • 2011-01-14. Osteoblast Interactions Within a Biomimetic Apatite Microenvironment in ANNALS OF BIOMEDICAL ENGINEERING
  • 2005-05. Cement from magnesium substituted hydroxyapatite in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 2003-06. Development of a fully injectable calcium phosphate cement for orthopedic and dental applications in BULLETIN OF MATERIALS SCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10856-015-5589-x

    DOI

    http://dx.doi.org/10.1007/s10856-015-5589-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006046815

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26511138


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