PolyNaSS grafting on titanium surfaces enhances osteoblast differentiation and inhibits Staphylococcus aureus adhesion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

A. Alcheikh, G. Pavon-Djavid, G. Helary, H. Petite, V. Migonney, F. Anagnostou

ABSTRACT

Titanium surface modifications to simultaneously prevent bacterial adhesion but promote bone-cell functions could be highly beneficial for improving implant osseointegration. In the present in vitro study, the effect of sulfonate groups on titanium surfaces was investigated with respect to both S. aureus adhesion and osteoblast functions pertinent to new bone formation. Commercial pure titanium (cpTi) squares were oxydized (Tiox), grafted with poly(sodium styrene sulfonate) groups (Tigraft) by covalent bonding using radical polymerization, and were characterized by infrared spectroscopy (HATR-FTIR) and colorimetry. Bacterial adhesion study showed that Tigraft exhibited high inhibition of S. aureus adhesion S at levels >90 %, when compared to cpTi (P < 0.05). In contrast osteoblasts adhesion was similar on all three titanium surfaces. While the kinetics of cell proliferation were similar on the three titanium surfaces, Alkaline phosphatase-specific activity of osteoblasts cultured on Tigraft surfaces was twofold higher than that observed on either on Tiox or cpTi surfaces (P < 0.01). More importantly, the amount and the distribution of calcium-containing nodules was different. The total area covered by calcium-containing nodules was 2.2-fold higher on the Tigraft as compared to either Tiox or cpTi surfaces (P < 0.01). These results provide evidence that poly(sodium styrene sulfonate) groups grafting on cpTi simultaneously inhibits bacteria adhesion but promote osteoblast function pertinent to new bone formation. Such modified titanium surfaces offer a promising strategy for preventing biofilm-related infections and enhancing osteointegration of implants in orthopaedic and dental applications. More... »

PAGES

1745-1754

References to SciGraph publications

  • 2011-03. In vitro adhesion of staphylococci to diamond-like carbon polymer hybrids under dynamic flow conditions in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 2004-09. Surface treatments and roughness properties of Ti-based biomaterials in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 2010-02. Bone tissue response to titanium implant surfaces modified with carboxylate and sulfonate groups in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10856-013-4932-3

    DOI

    http://dx.doi.org/10.1007/s10856-013-4932-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045771749

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23625318


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