Preparation of core–shell poly(l-lactic) acid-nanocrystalline apatite hollow microspheres for bone repairing applications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08-05

AUTHORS

Michele Iafisco, Barbara Palazzo, Tomoko Ito, Makoto Otsuka, Mamoru Senna, Josè Manuel Delgado-Lopez, Jaime Gomez-Morales, Anna Tampieri, Maria Prat, Lia Rimondini

ABSTRACT

In this paper, hybrid inorganic–organic core–shell hollow microspheres, made of poly(l-lactic acid) (PLLA) and biomimetic nano apatites (HA), were prepared from biodegradable and biocompatible substances, suitable for bone tissue applications. Preparation is started from Pickering emulsification, i.e., solid particle-stabilized emulsions in the absence of any molecular surfactant, where solid particles adsorbed to an oil–water interface. Stable oil-in-water emulsions were produced using biomimetic 20 nm sized HA nanocrystals as particulate emulsifier and a dichloromethane (CH2Cl2) solution of PLLA as oil phase. Hybrid hollow PLLA microspheres at three different HA nanocrystals surface coverage, ranging from 10 to 50 μm, were produced. The resulting materials were completely characterized with spectroscopic, calorimetric and microscopic techniques and the cytocompatibility was established by indirect contact tests with both fibroblasts and osteoblasts and direct contact with these latter. They displayed a high level of cytocompatibility and thus represent promising materials for drug delivery systems, cell carriers and scaffolds for regeneration of bone useful in the treatment of orthopaedic, maxillofacial and dental fields. More... »

PAGES

2659-2669

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-012-4732-1

DOI

http://dx.doi.org/10.1007/s10856-012-4732-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034752239

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22864504


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biocompatible Materials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Substitutes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calorimetry, Differential Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microspheres", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Particle Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyesters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spectroscopy, Fourier Transform Infrared", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Ray Diffraction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dipartimento di Chimica \u201cG. Ciamician\u201d, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy", 
          "id": "http://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy", 
            "Dipartimento di Chimica \u201cG. Ciamician\u201d, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iafisco", 
        "givenName": "Michele", 
        "id": "sg:person.0727410013.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727410013.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GHIMAS SpA, MeLab, Cittadella della Ricerca, SS7 per Mesagne, 72100, Brindisi, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "GHIMAS SpA, MeLab, Cittadella della Ricerca, SS7 per Mesagne, 72100, Brindisi, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palazzo", 
        "givenName": "Barbara", 
        "id": "sg:person.01176776157.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176776157.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411867.d", 
          "name": [
            "Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Tomoko", 
        "id": "sg:person.01132020041.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132020041.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411867.d", 
          "name": [
            "Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otsuka", 
        "givenName": "Makoto", 
        "id": "sg:person.01032304265.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032304265.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Science and Technology, Keio University, 223-8522, Hiyoshi, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan", 
            "Faculty of Science and Technology, Keio University, 223-8522, Hiyoshi, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senna", 
        "givenName": "Mamoru", 
        "id": "sg:person.011363404413.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011363404413.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Estudios Cristalogr\u00e1ficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratorio de Estudios Cristalogr\u00e1ficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delgado-Lopez", 
        "givenName": "Jos\u00e8 Manuel", 
        "id": "sg:person.0601640051.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601640051.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Estudios Cristalogr\u00e1ficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratorio de Estudios Cristalogr\u00e1ficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez-Morales", 
        "givenName": "Jaime", 
        "id": "sg:person.01100430251.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100430251.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto di Scienza e Tecnologia dei Materiali Ceramici, Consiglio Nazionale delle Ricerche, Via Granarolo 64, 48018, Faenza, RA, Italy", 
          "id": "http://www.grid.ac/institutes/grid.494561.b", 
          "name": [
            "Istituto di Scienza e Tecnologia dei Materiali Ceramici, Consiglio Nazionale delle Ricerche, Via Granarolo 64, 48018, Faenza, RA, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tampieri", 
        "givenName": "Anna", 
        "id": "sg:person.01330144172.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330144172.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy", 
          "id": "http://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prat", 
        "givenName": "Maria", 
        "id": "sg:person.01150401507.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150401507.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy", 
          "id": "http://www.grid.ac/institutes/grid.16563.37", 
          "name": [
            "Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rimondini", 
        "givenName": "Lia", 
        "id": "sg:person.01044377206.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044377206.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10856-010-4161-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015136446", 
          "https://doi.org/10.1007/s10856-010-4161-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-008-9759-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033018631", 
          "https://doi.org/10.1007/s11095-008-9759-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-69002-5_55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016723686", 
          "https://doi.org/10.1007/978-0-387-69002-5_55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10856-011-4232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345884", 
          "https://doi.org/10.1007/s10856-011-4232-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10856-010-4110-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018727275", 
          "https://doi.org/10.1007/s10856-010-4110-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00021145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051540178", 
          "https://doi.org/10.1007/pl00021145"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08-05", 
    "datePublishedReg": "2012-08-05", 
    "description": "In this paper, hybrid inorganic\u2013organic core\u2013shell hollow microspheres, made of poly(l-lactic acid) (PLLA) and biomimetic nano apatites (HA), were prepared from biodegradable and biocompatible substances, suitable for bone tissue applications. Preparation is started from Pickering emulsification, i.e., solid particle-stabilized emulsions in the absence of any molecular surfactant, where solid particles adsorbed to an oil\u2013water interface. Stable oil-in-water emulsions were produced using biomimetic 20\u00a0nm sized HA nanocrystals as particulate emulsifier and a dichloromethane (CH2Cl2) solution of PLLA as oil phase. Hybrid hollow PLLA microspheres at three different HA nanocrystals surface coverage, ranging from 10 to 50\u00a0\u03bcm, were produced. The resulting materials were completely characterized with spectroscopic, calorimetric and microscopic techniques and the cytocompatibility was established by indirect contact tests with both fibroblasts and osteoblasts and direct contact with these latter. They displayed a high level of cytocompatibility and thus represent promising materials for drug delivery systems, cell carriers and scaffolds for regeneration of bone useful in the treatment of orthopaedic, maxillofacial and dental fields.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10856-012-4732-1", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6072996", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1100668", 
        "issn": [
          "0957-4530", 
          "1573-4838"
        ], 
        "name": "Journal of Materials Science: Materials in Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "hollow microspheres", 
      "particle-stabilized emulsions", 
      "core-shell hollow microspheres", 
      "oil-water interface", 
      "drug delivery systems", 
      "molecular surfactants", 
      "dichloromethane solution", 
      "water emulsions", 
      "bone tissue applications", 
      "stable oil", 
      "bone repairing applications", 
      "oil phase", 
      "surface coverage", 
      "biocompatible substances", 
      "indirect contact tests", 
      "PLLA microspheres", 
      "promising material", 
      "nano-apatite", 
      "HA nanocrystals", 
      "solid particles", 
      "regeneration of bone", 
      "delivery system", 
      "tissue applications", 
      "microspheres", 
      "microscopic techniques", 
      "emulsions", 
      "cell carriers", 
      "cytocompatibility", 
      "preparation", 
      "emulsifiers", 
      "surfactants", 
      "nanocrystals", 
      "emulsification", 
      "contact test", 
      "materials", 
      "calorimetric", 
      "PLLA", 
      "dental field", 
      "scaffolds", 
      "applications", 
      "direct contact", 
      "particles", 
      "interface", 
      "oil", 
      "carriers", 
      "solution", 
      "substances", 
      "apatite", 
      "phase", 
      "regeneration", 
      "contact", 
      "field", 
      "coverage", 
      "technique", 
      "system", 
      "test", 
      "paper", 
      "bone", 
      "absence", 
      "osteoblasts", 
      "high levels", 
      "fibroblasts", 
      "treatment", 
      "levels"
    ], 
    "name": "Preparation of core\u2013shell poly(l-lactic) acid-nanocrystalline apatite hollow microspheres for bone repairing applications", 
    "pagination": "2659-2669", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034752239"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10856-012-4732-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22864504"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10856-012-4732-1", 
      "https://app.dimensions.ai/details/publication/pub.1034752239"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_577.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10856-012-4732-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10856-012-4732-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10856-012-4732-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10856-012-4732-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10856-012-4732-1'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      21 PREDICATES      112 URIs      98 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10856-012-4732-1 schema:about N10db8f97bbaa4395a149555ce9a50c40
2 N18ecc49e932242d49b77a98cce247173
3 N28ec83d12c77443b925c05c8e8912a36
4 N29f73d53f9c7448ca3cf13f68c4d2619
5 N3e8eb389b31143d7b90dbb08433771c1
6 N466401f12ccd412a84b07ae0239df0df
7 N70cbec34eaa1473a9ac7e25c6709785a
8 N714a6fd32f624bbfb5af31ebe219efb7
9 N768dfbe039494dbaae4cddf492c45afb
10 N7bc5496329f447319b129f5e454abad4
11 N85540a6fbf7d4d6c8b4f4ff619984b21
12 N8c006fa0f40e4904bebf9a07424b98d9
13 N97569c9f99214ef5a9f227a2239638be
14 N994317d8a86b4e0a9cc3f9a1812c9713
15 Na3df7f7aec2b4a7f9aeb7705d1044f48
16 Ned0fae4f4680450d82e21346b5002479
17 Nff9529ac2e4d4a95949c133c56f15cdd
18 anzsrc-for:09
19 anzsrc-for:0903
20 schema:author N2e435c04f6384286b31440f463fc25b1
21 schema:citation sg:pub.10.1007/978-0-387-69002-5_55
22 sg:pub.10.1007/pl00021145
23 sg:pub.10.1007/s10856-010-4110-9
24 sg:pub.10.1007/s10856-010-4161-y
25 sg:pub.10.1007/s10856-011-4232-8
26 sg:pub.10.1007/s11095-008-9759-0
27 schema:datePublished 2012-08-05
28 schema:datePublishedReg 2012-08-05
29 schema:description In this paper, hybrid inorganic–organic core–shell hollow microspheres, made of poly(l-lactic acid) (PLLA) and biomimetic nano apatites (HA), were prepared from biodegradable and biocompatible substances, suitable for bone tissue applications. Preparation is started from Pickering emulsification, i.e., solid particle-stabilized emulsions in the absence of any molecular surfactant, where solid particles adsorbed to an oil–water interface. Stable oil-in-water emulsions were produced using biomimetic 20 nm sized HA nanocrystals as particulate emulsifier and a dichloromethane (CH2Cl2) solution of PLLA as oil phase. Hybrid hollow PLLA microspheres at three different HA nanocrystals surface coverage, ranging from 10 to 50 μm, were produced. The resulting materials were completely characterized with spectroscopic, calorimetric and microscopic techniques and the cytocompatibility was established by indirect contact tests with both fibroblasts and osteoblasts and direct contact with these latter. They displayed a high level of cytocompatibility and thus represent promising materials for drug delivery systems, cell carriers and scaffolds for regeneration of bone useful in the treatment of orthopaedic, maxillofacial and dental fields.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N4575eeaf1aa048dfb604b013040180be
33 Nd81b56f68e984ad7a77592eadfc2da29
34 sg:journal.1100668
35 schema:keywords HA nanocrystals
36 PLLA
37 PLLA microspheres
38 absence
39 apatite
40 applications
41 biocompatible substances
42 bone
43 bone repairing applications
44 bone tissue applications
45 calorimetric
46 carriers
47 cell carriers
48 contact
49 contact test
50 core-shell hollow microspheres
51 coverage
52 cytocompatibility
53 delivery system
54 dental field
55 dichloromethane solution
56 direct contact
57 drug delivery systems
58 emulsification
59 emulsifiers
60 emulsions
61 fibroblasts
62 field
63 high levels
64 hollow microspheres
65 indirect contact tests
66 interface
67 levels
68 materials
69 microscopic techniques
70 microspheres
71 molecular surfactants
72 nano-apatite
73 nanocrystals
74 oil
75 oil phase
76 oil-water interface
77 osteoblasts
78 paper
79 particle-stabilized emulsions
80 particles
81 phase
82 preparation
83 promising material
84 regeneration
85 regeneration of bone
86 scaffolds
87 solid particles
88 solution
89 stable oil
90 substances
91 surface coverage
92 surfactants
93 system
94 technique
95 test
96 tissue applications
97 treatment
98 water emulsions
99 schema:name Preparation of core–shell poly(l-lactic) acid-nanocrystalline apatite hollow microspheres for bone repairing applications
100 schema:pagination 2659-2669
101 schema:productId N46d1d3a682d147cfa9173f9c0e011811
102 N548080bd7ee0427eb8c050c23400d459
103 Nbf9ea13a9f164799a8f653214e7b5940
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034752239
105 https://doi.org/10.1007/s10856-012-4732-1
106 schema:sdDatePublished 2022-10-01T06:38
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N16c2bf85c3a6478f91f4618cc3cfbf60
109 schema:url https://doi.org/10.1007/s10856-012-4732-1
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N10db8f97bbaa4395a149555ce9a50c40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Particle Size
115 rdf:type schema:DefinedTerm
116 N16c2bf85c3a6478f91f4618cc3cfbf60 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N18ecc49e932242d49b77a98cce247173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Microspheres
120 rdf:type schema:DefinedTerm
121 N287ae62034f7476bb2caeff99aea6253 rdf:first sg:person.01132020041.15
122 rdf:rest N44ea64c711684a49aa5f69e72a337aba
123 N28ec83d12c77443b925c05c8e8912a36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name X-Ray Diffraction
125 rdf:type schema:DefinedTerm
126 N29f73d53f9c7448ca3cf13f68c4d2619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 N2aeb691e189444528365e50c89777db8 rdf:first sg:person.0601640051.57
130 rdf:rest Ndf2671bb18c34f04b4b38638e74c4c5e
131 N2e435c04f6384286b31440f463fc25b1 rdf:first sg:person.0727410013.47
132 rdf:rest Ned0f5325c2284071b94e325f3e81bbeb
133 N3e8eb389b31143d7b90dbb08433771c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Crystallization
135 rdf:type schema:DefinedTerm
136 N44ea64c711684a49aa5f69e72a337aba rdf:first sg:person.01032304265.79
137 rdf:rest Nfafa4e035e0d4174a07ccda5ac58fb3d
138 N4575eeaf1aa048dfb604b013040180be schema:volumeNumber 23
139 rdf:type schema:PublicationVolume
140 N466401f12ccd412a84b07ae0239df0df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Tissue Engineering
142 rdf:type schema:DefinedTerm
143 N46d1d3a682d147cfa9173f9c0e011811 schema:name doi
144 schema:value 10.1007/s10856-012-4732-1
145 rdf:type schema:PropertyValue
146 N548080bd7ee0427eb8c050c23400d459 schema:name pubmed_id
147 schema:value 22864504
148 rdf:type schema:PropertyValue
149 N6246c8debc48460cb1b23f7f76ca23b1 rdf:first sg:person.01044377206.04
150 rdf:rest rdf:nil
151 N70cbec34eaa1473a9ac7e25c6709785a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Osteoblasts
153 rdf:type schema:DefinedTerm
154 N714a6fd32f624bbfb5af31ebe219efb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Polymers
156 rdf:type schema:DefinedTerm
157 N768dfbe039494dbaae4cddf492c45afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Spectroscopy, Fourier Transform Infrared
159 rdf:type schema:DefinedTerm
160 N7bc5496329f447319b129f5e454abad4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Microscopy, Electron, Scanning
162 rdf:type schema:DefinedTerm
163 N85540a6fbf7d4d6c8b4f4ff619984b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Polyesters
165 rdf:type schema:DefinedTerm
166 N8c006fa0f40e4904bebf9a07424b98d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Lactic Acid
168 rdf:type schema:DefinedTerm
169 N97569c9f99214ef5a9f227a2239638be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cells, Cultured
171 rdf:type schema:DefinedTerm
172 N994317d8a86b4e0a9cc3f9a1812c9713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Biocompatible Materials
174 rdf:type schema:DefinedTerm
175 Na3df7f7aec2b4a7f9aeb7705d1044f48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Calorimetry, Differential Scanning
177 rdf:type schema:DefinedTerm
178 Nbf9ea13a9f164799a8f653214e7b5940 schema:name dimensions_id
179 schema:value pub.1034752239
180 rdf:type schema:PropertyValue
181 Nc80798943a2f48fa910ee47b676fcdeb rdf:first sg:person.01330144172.71
182 rdf:rest Ne32e1a6103a6420d9c479b363a771013
183 Nd81b56f68e984ad7a77592eadfc2da29 schema:issueNumber 11
184 rdf:type schema:PublicationIssue
185 Ndf2671bb18c34f04b4b38638e74c4c5e rdf:first sg:person.01100430251.90
186 rdf:rest Nc80798943a2f48fa910ee47b676fcdeb
187 Ne32e1a6103a6420d9c479b363a771013 rdf:first sg:person.01150401507.30
188 rdf:rest N6246c8debc48460cb1b23f7f76ca23b1
189 Ned0f5325c2284071b94e325f3e81bbeb rdf:first sg:person.01176776157.32
190 rdf:rest N287ae62034f7476bb2caeff99aea6253
191 Ned0fae4f4680450d82e21346b5002479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Bone Substitutes
193 rdf:type schema:DefinedTerm
194 Nfafa4e035e0d4174a07ccda5ac58fb3d rdf:first sg:person.011363404413.06
195 rdf:rest N2aeb691e189444528365e50c89777db8
196 Nff9529ac2e4d4a95949c133c56f15cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Fluorescent Antibody Technique
198 rdf:type schema:DefinedTerm
199 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
200 schema:name Engineering
201 rdf:type schema:DefinedTerm
202 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biomedical Engineering
204 rdf:type schema:DefinedTerm
205 sg:grant.6072996 http://pending.schema.org/fundedItem sg:pub.10.1007/s10856-012-4732-1
206 rdf:type schema:MonetaryGrant
207 sg:journal.1100668 schema:issn 0957-4530
208 1573-4838
209 schema:name Journal of Materials Science: Materials in Medicine
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01032304265.79 schema:affiliation grid-institutes:grid.411867.d
213 schema:familyName Otsuka
214 schema:givenName Makoto
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032304265.79
216 rdf:type schema:Person
217 sg:person.01044377206.04 schema:affiliation grid-institutes:grid.16563.37
218 schema:familyName Rimondini
219 schema:givenName Lia
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044377206.04
221 rdf:type schema:Person
222 sg:person.01100430251.90 schema:affiliation grid-institutes:None
223 schema:familyName Gomez-Morales
224 schema:givenName Jaime
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100430251.90
226 rdf:type schema:Person
227 sg:person.01132020041.15 schema:affiliation grid-institutes:grid.411867.d
228 schema:familyName Ito
229 schema:givenName Tomoko
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132020041.15
231 rdf:type schema:Person
232 sg:person.011363404413.06 schema:affiliation grid-institutes:grid.26091.3c
233 schema:familyName Senna
234 schema:givenName Mamoru
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011363404413.06
236 rdf:type schema:Person
237 sg:person.01150401507.30 schema:affiliation grid-institutes:grid.16563.37
238 schema:familyName Prat
239 schema:givenName Maria
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150401507.30
241 rdf:type schema:Person
242 sg:person.01176776157.32 schema:affiliation grid-institutes:None
243 schema:familyName Palazzo
244 schema:givenName Barbara
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176776157.32
246 rdf:type schema:Person
247 sg:person.01330144172.71 schema:affiliation grid-institutes:grid.494561.b
248 schema:familyName Tampieri
249 schema:givenName Anna
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330144172.71
251 rdf:type schema:Person
252 sg:person.0601640051.57 schema:affiliation grid-institutes:None
253 schema:familyName Delgado-Lopez
254 schema:givenName Josè Manuel
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601640051.57
256 rdf:type schema:Person
257 sg:person.0727410013.47 schema:affiliation grid-institutes:grid.6292.f
258 schema:familyName Iafisco
259 schema:givenName Michele
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727410013.47
261 rdf:type schema:Person
262 sg:pub.10.1007/978-0-387-69002-5_55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016723686
263 https://doi.org/10.1007/978-0-387-69002-5_55
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/pl00021145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051540178
266 https://doi.org/10.1007/pl00021145
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s10856-010-4110-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018727275
269 https://doi.org/10.1007/s10856-010-4110-9
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s10856-010-4161-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015136446
272 https://doi.org/10.1007/s10856-010-4161-y
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s10856-011-4232-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035345884
275 https://doi.org/10.1007/s10856-011-4232-8
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s11095-008-9759-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033018631
278 https://doi.org/10.1007/s11095-008-9759-0
279 rdf:type schema:CreativeWork
280 grid-institutes:None schema:alternateName GHIMAS SpA, MeLab, Cittadella della Ricerca, SS7 per Mesagne, 72100, Brindisi, Italy
281 Laboratorio de Estudios Cristalográficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain
282 schema:name GHIMAS SpA, MeLab, Cittadella della Ricerca, SS7 per Mesagne, 72100, Brindisi, Italy
283 Laboratorio de Estudios Cristalográficos, IACT (CSIC-UGR), Avda. de las Palmeras, 4, 18100, Armilla, Granada, Spain
284 rdf:type schema:Organization
285 grid-institutes:grid.16563.37 schema:alternateName Dipartimento di Scienze della Salute, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy
286 schema:name Dipartimento di Scienze della Salute, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy
287 rdf:type schema:Organization
288 grid-institutes:grid.26091.3c schema:alternateName Faculty of Science and Technology, Keio University, 223-8522, Hiyoshi, Yokohama, Japan
289 schema:name Faculty of Science and Technology, Keio University, 223-8522, Hiyoshi, Yokohama, Japan
290 Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan
291 rdf:type schema:Organization
292 grid-institutes:grid.411867.d schema:alternateName Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan
293 schema:name Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi 1-1-20, 202-8585, Nishitokyo-Shi, Tokyo, Japan
294 rdf:type schema:Organization
295 grid-institutes:grid.494561.b schema:alternateName Istituto di Scienza e Tecnologia dei Materiali Ceramici, Consiglio Nazionale delle Ricerche, Via Granarolo 64, 48018, Faenza, RA, Italy
296 schema:name Istituto di Scienza e Tecnologia dei Materiali Ceramici, Consiglio Nazionale delle Ricerche, Via Granarolo 64, 48018, Faenza, RA, Italy
297 rdf:type schema:Organization
298 grid-institutes:grid.6292.f schema:alternateName Dipartimento di Chimica “G. Ciamician”, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy
299 schema:name Dipartimento di Chimica “G. Ciamician”, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy
300 Dipartimento di Scienze della Salute, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...