Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03-04

AUTHORS

Tomoko Ito, Mami Saito, Tomohiro Uchino, Mamoru Senna, Michele Iafisco, Maria Prat, Lia Rimondini, Makoto Otsuka

ABSTRACT

Highly soluble amorphous calcium phosphate powder (ACP) was added to the alginate gel as a buffering agent, in an attempt to enable widely controlled release while avoiding an acidification of the gel-environment. Therapeutic effects of the ACP-containing alginate gel which slowly releases a drug, simvastatin, on osteoporosis model rats were examined. A model drug, simvastatin, incorporated in the alginate gel with ACP up to 0.5%, was continuously released for a long time under the acidic condition. The release rate was controlled by the amount of ACP, serving as a buffer to suppress acidity. When the alginate solution intramuscularly injected in the rat, a soft gel was formed in the injected site. Simvastatin released from the gel containing 0.5% of ACP showed high therapeutic effect on osteoporosis rat. Thus, the present injectable long-sustained release system is expected to be a novel drug delivery controlling device. More... »

PAGES

1291-1297

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-012-4597-3

DOI

http://dx.doi.org/10.1007/s10856-012-4597-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000867887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22391994


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