Ontology type: schema:ScholarlyArticle
2012-02
AUTHORSNikolaos Scoutaris, Andrew L. Hook, Paul R. Gellert, Clive J. Roberts, Morgan R. Alexander, David J. Scurr
ABSTRACTThree different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an individual micro-spot basis by time-of-flight secondary ion mass spectrometry (ToF-SIMS). For the HCT/PLGA formulation, the spots showed heterogeneity of the drug and other chemical constituents. To further investigate these heterogeneities, multivariate curve resolution was applied to the ToF-SIMS hyperspectral image datasets. This approach successfully identified distinct chemical components elucidating the HCT, PLGA, substrate material, and contaminants based on sulphur, phosphorous and sodium chloride. Spots printed using either of the drugs with PVP exhibited full substrate coverage and a uniform distribution of the active ingredient along with all other constituents within the printed spot area. This represents the preferred situation in terms of stability and controlling the release of a drug from a polymer matrix. More... »
PAGES385-391
http://scigraph.springernature.com/pub.10.1007/s10856-011-4474-5
DOIhttp://dx.doi.org/10.1007/s10856-011-4474-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1008912315
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22083856
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Macromolecular and Materials Chemistry",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemistry, Pharmaceutical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Delivery Systems",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Design",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Felodipine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydrochlorothiazide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lactic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mass Spectrometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microarray Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Chemical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyglycolic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyvinyls",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Printing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyrrolidinones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sodium Chloride",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spectrometry, Mass, Secondary Ion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Surface Properties",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Scoutaris",
"givenName": "Nikolaos",
"id": "sg:person.0660107717.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660107717.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Hook",
"givenName": "Andrew L.",
"id": "sg:person.01362765047.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362765047.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "AstraZeneca (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.417815.e",
"name": [
"AstraZeneca, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK"
],
"type": "Organization"
},
"familyName": "Gellert",
"givenName": "Paul R.",
"id": "sg:person.01110564717.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110564717.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Roberts",
"givenName": "Clive J.",
"id": "sg:person.01035336303.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035336303.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Alexander",
"givenName": "Morgan R.",
"id": "sg:person.0701505711.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701505711.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Scurr",
"givenName": "David J.",
"id": "sg:person.01250063121.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250063121.50"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1126/science.276.5320.1868",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003295975"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0142-9612(00)00115-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004843434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2006.04.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005195880"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.20697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015119935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(97)00048-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019350039"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2011.07.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025091161"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/9780470721582.ch10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029831767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1149/1.3536543",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033795485"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1012151006742",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034823062",
"https://doi.org/10.1023/a:1012151006742"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2007.03.037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037373224"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biomaterials.2005.12.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038140854"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejps.2005.01.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043027095"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-007-9331-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047710353",
"https://doi.org/10.1007/s11095-007-9331-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac000450+",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054968234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac000450+",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054968234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac071560k",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054999791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ac071560k",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054999791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/cc049840q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055227745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/cc049840q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055227745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la1029933",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056153034"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la1029933",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056153034"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-02",
"datePublishedReg": "2012-02-01",
"description": "Three different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an individual micro-spot basis by time-of-flight secondary ion mass spectrometry (ToF-SIMS). For the HCT/PLGA formulation, the spots showed heterogeneity of the drug and other chemical constituents. To further investigate these heterogeneities, multivariate curve resolution was applied to the ToF-SIMS hyperspectral image datasets. This approach successfully identified distinct chemical components elucidating the HCT, PLGA, substrate material, and contaminants based on sulphur, phosphorous and sodium chloride. Spots printed using either of the drugs with PVP exhibited full substrate coverage and a uniform distribution of the active ingredient along with all other constituents within the printed spot area. This represents the preferred situation in terms of stability and controlling the release of a drug from a polymer matrix.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10856-011-4474-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1100668",
"issn": [
"0957-4530",
"1573-4838"
],
"name": "Journal of Materials Science: Materials in Medicine",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "23"
}
],
"name": "ToF-SIMS analysis of chemical heterogenities in inkjet micro-array printed drug/polymer formulations",
"pagination": "385-391",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2a75c0cf89a9868e48f72fc306dd28c8565a09092129a37ddb2934a6e6571c12"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22083856"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9013087"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10856-011-4474-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1008912315"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10856-011-4474-5",
"https://app.dimensions.ai/details/publication/pub.1008912315"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:51",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000486.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s10856-011-4474-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4474-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4474-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4474-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4474-5'
This table displays all metadata directly associated to this object as RDF triples.
232 TRIPLES
21 PREDICATES
64 URIs
39 LITERALS
27 BLANK NODES