Mechanical effects, antimicrobial efficacy and cytotoxicity of usnic acid as a biofilm prophylaxis in PMMA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09-22

AUTHORS

Sunghwan Kim, Robert Greenleaf, Mark Carl Miller, Latha Satish, Sandeep Kathju, Garth Ehrlich, J. Christopher Post, Nicholas G. Sotereanos, Paul Stoodley

ABSTRACT

Experiments were performed to test the null hypothesis that the addition of a natural occurring antibiotic would not alter mechanical properties of polymethylmethacrylate (PMMA). Compression and four-point bending tests were used to assess mechanical properties of zirconium dioxide bearing bone cement (Type Zr) and barium sulfate bearing bone cement (Type Ba), mixed with the antibiotic usnic acid (“usnic”), used to create a surface resistant to biofilm formation. Addition of usnic had a statistically significant effect on the material properties. Compressive and bending strengths decreased as usnic was added and Type Zr was stronger than Type Ba although material properties remained above recommended minima. With implications of liver toxicity with large doses of usnic taken as a dietary supplement, cytotoxicity tests using bone cement coupons were performed and showed very little or no toxicity in primary cultures of rabbit skin derived fibroblasts. A simple test of usnic’s efficacy as a biofilm prophylaxis in PMMA was also conducted. Bone cement coupons with usnic were tested for their effectiveness against methicillin resistant Staphylococcus aureus. Diminished biofilm formation on usnic-containing coupons indicated that usnic can be an effective anti-microbial agent. More... »

PAGES

2773-2780

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-011-4445-x

DOI

http://dx.doi.org/10.1007/s10856-011-4445-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016379675

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21938390


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