Fabrication and cell affinity of biomimetic structured PLGA/articular cartilage ECM composite scaffold View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03

AUTHORS

Xifu Zheng, Fei Yang, Shenguo Wang, Shibi Lu, Weiguo Zhang, Shuyun Liu, Jingxiang Huang, Aiyuan Wang, Baosheng Yin, Ning Ma, Li Zhang, Wenjing Xu, Quanyi Guo

ABSTRACT

An ideal scaffold for cartilage tissue engineering should be biomimetic in not only mechanical property and biochemical composition, but also the morphological structure. In this research, we fabricated a composite scaffold with oriented structure to mimic cartilage physiological morphology, where natural nanofibrous articular cartilage extracellular matrix (ACECM) was used to mimic the biochemical composition, and synthetic PLGA was used to enhance the mechanical strength of ACECM. The composite scaffold has well oriented structure and more than 89% of porosity as well as about 107 μm of average pore diameter. The composite scaffold was compared with ACECM and PLGA scaffolds. Cell proliferation test showed that the number of MSCs in ACECM and composite scaffolds was noticeably bigger than that in PLGA scaffold, which was coincident with results of SEM observation and cell viability staining. The water absorption of ACECM and composite scaffolds were 22.1 and 10.2 times respectively, which was much higher than that of PLGA scaffolds (3.8 times). The compressive modulus of composite scaffold in hydrous status was 1.03 MPa, which was near 10 times higher than that of hydrous ACECM scaffold. The aforementioned results suggested that the composite scaffold has the potential for application in cartilage tissue engineering. More... »

PAGES

693-704

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-011-4248-0

DOI

http://dx.doi.org/10.1007/s10856-011-4248-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014081153

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21287238


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomimetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cartilage, Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanostructures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyglycolic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Porosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Mechanical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, 116011, Dalian, China", 
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Xifu", 
        "id": "sg:person.014172316304.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172316304.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418929.f", 
          "name": [
            "BNLMS, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Fei", 
        "id": "sg:person.01037540467.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037540467.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418929.f", 
          "name": [
            "BNLMS, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Shenguo", 
        "id": "sg:person.01016152455.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016152455.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Shibi", 
        "id": "sg:person.01000022117.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000022117.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Affiliated Hospital of Dalian Medical University", 
          "id": "https://www.grid.ac/institutes/grid.452435.1", 
          "name": [
            "Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, 116011, Dalian, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Weiguo", 
        "id": "sg:person.01052111761.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052111761.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Shuyun", 
        "id": "sg:person.0744221262.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744221262.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jingxiang", 
        "id": "sg:person.0703132326.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703132326.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Aiyuan", 
        "id": "sg:person.0663737024.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663737024.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yin", 
        "givenName": "Baosheng", 
        "id": "sg:person.012210036261.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012210036261.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Ning", 
        "id": "sg:person.01326556634.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326556634.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Li", 
        "id": "sg:person.01126563062.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126563062.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Wenjing", 
        "id": "sg:person.016033054053.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033054053.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414252.4", 
          "name": [
            "Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Quanyi", 
        "id": "sg:person.012344521067.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344521067.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0142-9612(00)00174-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002757067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.08.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003858011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.32381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004260717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004268381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-8186-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004665387", 
          "https://doi.org/10.1007/978-1-4615-8186-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-8186-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004665387", 
          "https://doi.org/10.1007/978-1-4615-8186-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-8186-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004665387", 
          "https://doi.org/10.1007/978-1-4615-8186-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2008.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008846258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.09.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013556523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2006.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014897902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2008.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015954416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.01.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019654723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/joca.2001.0504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019809801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021902763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021928921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028229677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiomech.2004.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031730822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08941938909016503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032222452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032733277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033559484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.11.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034203062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2004.06.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034607878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2004.10.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035546646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.01.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035596070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.09.089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036649649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.02.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037580539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.31816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038713989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:jmsm.0000030216.73274.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039266542", 
          "https://doi.org/10.1023/b:jmsm.0000030216.73274.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.07.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040271827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.30614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043054131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.30614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043054131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.07.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043615202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046689872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4636(20010915)56:4<469::aid-jbm1118>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047459075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pat.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047589011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2004.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048028211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.09.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049599035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.1995.1.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059312993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.2006.12.1775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059313760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2008.0109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315367"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03", 
    "datePublishedReg": "2011-03-01", 
    "description": "An ideal scaffold for cartilage tissue engineering should be biomimetic in not only mechanical property and biochemical composition, but also the morphological structure. In this research, we fabricated a composite scaffold with oriented structure to mimic cartilage physiological morphology, where natural nanofibrous articular cartilage extracellular matrix (ACECM) was used to mimic the biochemical composition, and synthetic PLGA was used to enhance the mechanical strength of ACECM. The composite scaffold has well oriented structure and more than 89% of porosity as well as about 107 \u03bcm of average pore diameter. The composite scaffold was compared with ACECM and PLGA scaffolds. Cell proliferation test showed that the number of MSCs in ACECM and composite scaffolds was noticeably bigger than that in PLGA scaffold, which was coincident with results of SEM observation and cell viability staining. The water absorption of ACECM and composite scaffolds were 22.1 and 10.2 times respectively, which was much higher than that of PLGA scaffolds (3.8 times). The compressive modulus of composite scaffold in hydrous status was 1.03 MPa, which was near 10 times higher than that of hydrous ACECM scaffold. The aforementioned results suggested that the composite scaffold has the potential for application in cartilage tissue engineering.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10856-011-4248-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4955410", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1100668", 
        "issn": [
          "0957-4530", 
          "1573-4838"
        ], 
        "name": "Journal of Materials Science: Materials in Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Fabrication and cell affinity of biomimetic structured PLGA/articular cartilage ECM composite scaffold", 
    "pagination": "693-704", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4314c59d8639b19bcd93da843b287a7f1cfcaeca5f5150bf1cb6f9be29f9f7cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21287238"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9013087"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10856-011-4248-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014081153"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10856-011-4248-0", 
      "https://app.dimensions.ai/details/publication/pub.1014081153"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000487.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10856-011-4248-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4248-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4248-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4248-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10856-011-4248-0'


 

This table displays all metadata directly associated to this object as RDF triples.

346 TRIPLES      21 PREDICATES      84 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10856-011-4248-0 schema:about N18db8d04087e4bbba55fcf46bddb4c40
2 N29b5e29edfe94217af2f02e9cf7edffe
3 N322a49e5b72d499a86e127a5110b7eca
4 N3e097d74f4ef44bc88f419fb80699feb
5 N43ddb64fee824c9e8b4cb896372a676b
6 N7635e0f14c974bdca9d29f6394cb3b1a
7 N7654b7a05fd84ac08da5e1f2123bab2c
8 N7b9250e1239543ffb0d81f9e89ff4597
9 N8af7926956174a99bc8f58be4571eebd
10 N908cbc85f9804626885b94952f4831bc
11 Nc47c7801e4f941458f57a33786f83205
12 Nc8ee2c4e1af547588f227181ad2a1ab4
13 Ne5b368417f064312982fb5cf1bebbcaf
14 Ne79324c89a924074bc6a7418b0730d76
15 Ne8730d5508294132bf2ef6d812f0d9b6
16 Nee1a147c64de478fa900d5c1adecaf47
17 Nfb6e96bfa73a4db0bef24e6801f83da4
18 anzsrc-for:09
19 anzsrc-for:0903
20 schema:author N285988ca16274fa48b0440668b1027a7
21 schema:citation sg:pub.10.1007/978-1-4615-8186-4
22 sg:pub.10.1023/b:jmsm.0000030216.73274.86
23 https://doi.org/10.1002/1097-4636(20010915)56:4<469::aid-jbm1118>3.0.co;2-h
24 https://doi.org/10.1002/jbm.a.30614
25 https://doi.org/10.1002/jbm.a.31816
26 https://doi.org/10.1002/jbm.a.32381
27 https://doi.org/10.1002/pat.178
28 https://doi.org/10.1016/j.actbio.2008.05.017
29 https://doi.org/10.1016/j.actbio.2008.07.030
30 https://doi.org/10.1016/j.biomaterials.2004.03.013
31 https://doi.org/10.1016/j.biomaterials.2004.06.051
32 https://doi.org/10.1016/j.biomaterials.2004.10.037
33 https://doi.org/10.1016/j.biomaterials.2006.01.041
34 https://doi.org/10.1016/j.biomaterials.2006.02.036
35 https://doi.org/10.1016/j.biomaterials.2006.05.028
36 https://doi.org/10.1016/j.biomaterials.2006.10.025
37 https://doi.org/10.1016/j.biomaterials.2008.01.037
38 https://doi.org/10.1016/j.biomaterials.2008.04.001
39 https://doi.org/10.1016/j.biomaterials.2008.08.031
40 https://doi.org/10.1016/j.biomaterials.2008.09.031
41 https://doi.org/10.1016/j.biomaterials.2009.01.018
42 https://doi.org/10.1016/j.biomaterials.2009.04.008
43 https://doi.org/10.1016/j.biomaterials.2009.06.013
44 https://doi.org/10.1016/j.biomaterials.2009.07.039
45 https://doi.org/10.1016/j.biomaterials.2009.07.062
46 https://doi.org/10.1016/j.biomaterials.2009.09.049
47 https://doi.org/10.1016/j.biomaterials.2009.09.089
48 https://doi.org/10.1016/j.biomaterials.2009.11.070
49 https://doi.org/10.1016/j.biomaterials.2010.02.006
50 https://doi.org/10.1016/j.jbiomech.2004.10.016
51 https://doi.org/10.1016/j.joca.2006.08.008
52 https://doi.org/10.1016/s0142-9612(00)00174-5
53 https://doi.org/10.1053/joca.2001.0504
54 https://doi.org/10.1089/ten.1995.1.3
55 https://doi.org/10.1089/ten.2006.12.1775
56 https://doi.org/10.1089/ten.tea.2008.0109
57 https://doi.org/10.1089/ten.tea.2009.0282
58 https://doi.org/10.3109/08941938909016503
59 schema:datePublished 2011-03
60 schema:datePublishedReg 2011-03-01
61 schema:description An ideal scaffold for cartilage tissue engineering should be biomimetic in not only mechanical property and biochemical composition, but also the morphological structure. In this research, we fabricated a composite scaffold with oriented structure to mimic cartilage physiological morphology, where natural nanofibrous articular cartilage extracellular matrix (ACECM) was used to mimic the biochemical composition, and synthetic PLGA was used to enhance the mechanical strength of ACECM. The composite scaffold has well oriented structure and more than 89% of porosity as well as about 107 μm of average pore diameter. The composite scaffold was compared with ACECM and PLGA scaffolds. Cell proliferation test showed that the number of MSCs in ACECM and composite scaffolds was noticeably bigger than that in PLGA scaffold, which was coincident with results of SEM observation and cell viability staining. The water absorption of ACECM and composite scaffolds were 22.1 and 10.2 times respectively, which was much higher than that of PLGA scaffolds (3.8 times). The compressive modulus of composite scaffold in hydrous status was 1.03 MPa, which was near 10 times higher than that of hydrous ACECM scaffold. The aforementioned results suggested that the composite scaffold has the potential for application in cartilage tissue engineering.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N1fd5ea8be608483483ee5227902ade25
66 Na7674a4edd634cde846bfb4972d9d0de
67 sg:journal.1100668
68 schema:name Fabrication and cell affinity of biomimetic structured PLGA/articular cartilage ECM composite scaffold
69 schema:pagination 693-704
70 schema:productId N2f6a6b7621554532afe0c8ebc1325b75
71 N3adb398b4df64e9bbf8cb4e7116d37fa
72 N42e247e17e5f4bc386591c89e3f0656a
73 N73c2d761a3ee4d34a5dec45d488780e5
74 Nb8309d32fe874de49fa1da7f0b0b1599
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014081153
76 https://doi.org/10.1007/s10856-011-4248-0
77 schema:sdDatePublished 2019-04-11T00:10
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Nd7bc6ea1031d4eae81be10adec832ced
80 schema:url http://link.springer.com/10.1007/s10856-011-4248-0
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N088c6cd57d71402ba780ae926b0633ac rdf:first sg:person.01016152455.23
85 rdf:rest N4ac599edec0c40c48a5b6c1f94be2a96
86 N18db8d04087e4bbba55fcf46bddb4c40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Rabbits
88 rdf:type schema:DefinedTerm
89 N1fd5ea8be608483483ee5227902ade25 schema:issueNumber 3
90 rdf:type schema:PublicationIssue
91 N285988ca16274fa48b0440668b1027a7 rdf:first sg:person.014172316304.29
92 rdf:rest N4d90a56adcf241b792341f77b7af62e0
93 N29b5e29edfe94217af2f02e9cf7edffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Mesenchymal Stromal Cells
95 rdf:type schema:DefinedTerm
96 N2f6a6b7621554532afe0c8ebc1325b75 schema:name doi
97 schema:value 10.1007/s10856-011-4248-0
98 rdf:type schema:PropertyValue
99 N322a49e5b72d499a86e127a5110b7eca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Immunohistochemistry
101 rdf:type schema:DefinedTerm
102 N3323ba34d6874655bd15d8a807d5e016 rdf:first sg:person.0663737024.96
103 rdf:rest N486062df254b407cb69d3952da984ca2
104 N36f28a70940a4258bc285ae180b136fe rdf:first sg:person.0703132326.91
105 rdf:rest N3323ba34d6874655bd15d8a807d5e016
106 N3adb398b4df64e9bbf8cb4e7116d37fa schema:name nlm_unique_id
107 schema:value 9013087
108 rdf:type schema:PropertyValue
109 N3e097d74f4ef44bc88f419fb80699feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Nanostructures
111 rdf:type schema:DefinedTerm
112 N42e247e17e5f4bc386591c89e3f0656a schema:name pubmed_id
113 schema:value 21287238
114 rdf:type schema:PropertyValue
115 N43ddb64fee824c9e8b4cb896372a676b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Lactic Acid
117 rdf:type schema:DefinedTerm
118 N486062df254b407cb69d3952da984ca2 rdf:first sg:person.012210036261.38
119 rdf:rest Na962c233629047fb8fb9951a86866a01
120 N4ac599edec0c40c48a5b6c1f94be2a96 rdf:first sg:person.01000022117.19
121 rdf:rest Nde0bcaa0c5c64eb9b04b7136b793737c
122 N4d90a56adcf241b792341f77b7af62e0 rdf:first sg:person.01037540467.36
123 rdf:rest N088c6cd57d71402ba780ae926b0633ac
124 N6335c00e027444cc94d43bc7a16b6816 rdf:first sg:person.016033054053.68
125 rdf:rest Nf4213ee5aedf464982af7d0a78811e8b
126 N73c2d761a3ee4d34a5dec45d488780e5 schema:name dimensions_id
127 schema:value pub.1014081153
128 rdf:type schema:PropertyValue
129 N7635e0f14c974bdca9d29f6394cb3b1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Tissue Engineering
131 rdf:type schema:DefinedTerm
132 N7654b7a05fd84ac08da5e1f2123bab2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Porosity
134 rdf:type schema:DefinedTerm
135 N7b9250e1239543ffb0d81f9e89ff4597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 N8af7926956174a99bc8f58be4571eebd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Survival
140 rdf:type schema:DefinedTerm
141 N8c4f38e510eb418ca937144feaedded7 rdf:first sg:person.0744221262.88
142 rdf:rest N36f28a70940a4258bc285ae180b136fe
143 N908cbc85f9804626885b94952f4831bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Tissue Scaffolds
145 rdf:type schema:DefinedTerm
146 Na7674a4edd634cde846bfb4972d9d0de schema:volumeNumber 22
147 rdf:type schema:PublicationVolume
148 Na962c233629047fb8fb9951a86866a01 rdf:first sg:person.01326556634.30
149 rdf:rest Nc8add541a8a84b7c81cb4f0b579b80ba
150 Nb8309d32fe874de49fa1da7f0b0b1599 schema:name readcube_id
151 schema:value 4314c59d8639b19bcd93da843b287a7f1cfcaeca5f5150bf1cb6f9be29f9f7cd
152 rdf:type schema:PropertyValue
153 Nc47c7801e4f941458f57a33786f83205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cell Proliferation
155 rdf:type schema:DefinedTerm
156 Nc8add541a8a84b7c81cb4f0b579b80ba rdf:first sg:person.01126563062.05
157 rdf:rest N6335c00e027444cc94d43bc7a16b6816
158 Nc8ee2c4e1af547588f227181ad2a1ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cartilage, Articular
160 rdf:type schema:DefinedTerm
161 Nd7bc6ea1031d4eae81be10adec832ced schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 Nde0bcaa0c5c64eb9b04b7136b793737c rdf:first sg:person.01052111761.11
164 rdf:rest N8c4f38e510eb418ca937144feaedded7
165 Ne5b368417f064312982fb5cf1bebbcaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Stress, Mechanical
167 rdf:type schema:DefinedTerm
168 Ne79324c89a924074bc6a7418b0730d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Microscopy, Electron, Scanning
170 rdf:type schema:DefinedTerm
171 Ne8730d5508294132bf2ef6d812f0d9b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Extracellular Matrix
173 rdf:type schema:DefinedTerm
174 Nee1a147c64de478fa900d5c1adecaf47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Polyglycolic Acid
176 rdf:type schema:DefinedTerm
177 Nf4213ee5aedf464982af7d0a78811e8b rdf:first sg:person.012344521067.36
178 rdf:rest rdf:nil
179 Nfb6e96bfa73a4db0bef24e6801f83da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Biomimetics
181 rdf:type schema:DefinedTerm
182 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
183 schema:name Engineering
184 rdf:type schema:DefinedTerm
185 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
186 schema:name Biomedical Engineering
187 rdf:type schema:DefinedTerm
188 sg:grant.4955410 http://pending.schema.org/fundedItem sg:pub.10.1007/s10856-011-4248-0
189 rdf:type schema:MonetaryGrant
190 sg:journal.1100668 schema:issn 0957-4530
191 1573-4838
192 schema:name Journal of Materials Science: Materials in Medicine
193 rdf:type schema:Periodical
194 sg:person.01000022117.19 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
195 schema:familyName Lu
196 schema:givenName Shibi
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000022117.19
198 rdf:type schema:Person
199 sg:person.01016152455.23 schema:affiliation https://www.grid.ac/institutes/grid.418929.f
200 schema:familyName Wang
201 schema:givenName Shenguo
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016152455.23
203 rdf:type schema:Person
204 sg:person.01037540467.36 schema:affiliation https://www.grid.ac/institutes/grid.418929.f
205 schema:familyName Yang
206 schema:givenName Fei
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037540467.36
208 rdf:type schema:Person
209 sg:person.01052111761.11 schema:affiliation https://www.grid.ac/institutes/grid.452435.1
210 schema:familyName Zhang
211 schema:givenName Weiguo
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052111761.11
213 rdf:type schema:Person
214 sg:person.01126563062.05 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
215 schema:familyName Zhang
216 schema:givenName Li
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126563062.05
218 rdf:type schema:Person
219 sg:person.012210036261.38 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
220 schema:familyName Yin
221 schema:givenName Baosheng
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012210036261.38
223 rdf:type schema:Person
224 sg:person.012344521067.36 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
225 schema:familyName Guo
226 schema:givenName Quanyi
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344521067.36
228 rdf:type schema:Person
229 sg:person.01326556634.30 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
230 schema:familyName Ma
231 schema:givenName Ning
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326556634.30
233 rdf:type schema:Person
234 sg:person.014172316304.29 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
235 schema:familyName Zheng
236 schema:givenName Xifu
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172316304.29
238 rdf:type schema:Person
239 sg:person.016033054053.68 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
240 schema:familyName Xu
241 schema:givenName Wenjing
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033054053.68
243 rdf:type schema:Person
244 sg:person.0663737024.96 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
245 schema:familyName Wang
246 schema:givenName Aiyuan
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663737024.96
248 rdf:type schema:Person
249 sg:person.0703132326.91 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
250 schema:familyName Huang
251 schema:givenName Jingxiang
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703132326.91
253 rdf:type schema:Person
254 sg:person.0744221262.88 schema:affiliation https://www.grid.ac/institutes/grid.414252.4
255 schema:familyName Liu
256 schema:givenName Shuyun
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744221262.88
258 rdf:type schema:Person
259 sg:pub.10.1007/978-1-4615-8186-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004665387
260 https://doi.org/10.1007/978-1-4615-8186-4
261 rdf:type schema:CreativeWork
262 sg:pub.10.1023/b:jmsm.0000030216.73274.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039266542
263 https://doi.org/10.1023/b:jmsm.0000030216.73274.86
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/1097-4636(20010915)56:4<469::aid-jbm1118>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1047459075
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/jbm.a.30614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043054131
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/jbm.a.31816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038713989
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/jbm.a.32381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004260717
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/pat.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047589011
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.actbio.2008.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008846258
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.actbio.2008.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015954416
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.biomaterials.2004.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048028211
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.biomaterials.2004.06.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607878
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.biomaterials.2004.10.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035546646
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.biomaterials.2006.01.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035596070
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.biomaterials.2006.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037580539
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.biomaterials.2006.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046689872
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.biomaterials.2006.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028229677
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.biomaterials.2008.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019654723
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.biomaterials.2008.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021928921
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.biomaterials.2008.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003858011
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.biomaterials.2008.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049599035
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.biomaterials.2009.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032733277
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.biomaterials.2009.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033559484
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.biomaterials.2009.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004268381
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.biomaterials.2009.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040271827
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.biomaterials.2009.07.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043615202
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.biomaterials.2009.09.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013556523
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.biomaterials.2009.09.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036649649
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.biomaterials.2009.11.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034203062
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.biomaterials.2010.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902763
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.jbiomech.2004.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031730822
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.joca.2006.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014897902
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0142-9612(00)00174-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002757067
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1053/joca.2001.0504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019809801
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1089/ten.1995.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059312993
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1089/ten.2006.12.1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059313760
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1089/ten.tea.2008.0109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315030
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1089/ten.tea.2009.0282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315367
334 rdf:type schema:CreativeWork
335 https://doi.org/10.3109/08941938909016503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032222452
336 rdf:type schema:CreativeWork
337 https://www.grid.ac/institutes/grid.414252.4 schema:alternateName Chinese PLA General Hospital
338 schema:name Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, 116011, Dalian, China
339 Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, 100853, Beijing, People’s Republic of China
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.418929.f schema:alternateName Institute of Chemistry
342 schema:name BNLMS, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.452435.1 schema:alternateName First Affiliated Hospital of Dalian Medical University
345 schema:name Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, 116011, Dalian, China
346 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...