In vivo biocompatibility assessment of (PTFE–PVDF–PP) terpolymer-based membrane with potential application for glaucoma treatment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07-23

AUTHORS

Rafał Leszczynski, Ewa Stodolak, Jarosław Wieczorek, Jolanta Orlowska-Heitzman, Teresa Gumula, Stanislaw Blazewicz

ABSTRACT

The aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE-PVDF-PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself. More... »

PAGES

2843-2851

References to SciGraph publications

  • 2008-02-28. Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 1999-01. Biodegradable tube impla in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • 2006-04-05. Outflow mechanisms after deep sclerectomy with two different designs of collagen implant in an animal model in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10856-010-4132-3

    DOI

    http://dx.doi.org/10.1007/s10856-010-4132-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041808493

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20652824


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