Control of drug loading efficiency and drug release behavior in preparation of hydrophilic-drug-containing monodisperse PLGA microspheres View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05

AUTHORS

Fuminori Ito, Hiroyuki Fujimori, Hiroyuki Honnami, Hiroyoshi Kawakami, Kiyoshi Kanamura, Kimiko Makino

ABSTRACT

We prepared monodisperse poly(lactide-co-glycolide) (PLGA) microspheres containing blue dextran (BLD)--a hydrophilic drug--by membrane emulsification technique. The effects of electrolyte addition to the w(2) phase and significance of the droplet size ratio between primary (w(1)/o) and secondary (w(1)/o/w(2)) emulsions during the preparation of these microspheres was examined. The droplet size ratio was evaluated from the effect of stirring rate of the homogenizer when preparing the primary emulsion. The drug loading efficiency of BLD in these microspheres increased with stirring rate. It increased to approximately 90% when 2.0% NaCl was added to the w(2) phase. Drug release from these microspheres was slower than that when they were prepared without electrolyte addition. Despite the very high efficiency drug release was gradual because BLD was distributed at the microspheres core. Relatively monodisperse hydrophilic-drug-containing PLGA microspheres with controlled drug loading efficiency and drug release behavior were prepared. More... »

PAGES

1563-1571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-010-3995-7

DOI

http://dx.doi.org/10.1007/s10856-010-3995-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053484651

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20221788


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