Antitumor efficacy of Poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03-27

AUTHORS

Wen-xun Guo, Zongli Shi, Fan-bing Zeng, Kui Liang, Xian-hong Chen, Yong-ping Ai, Min Fang, Xiao Sun, Zhi Zhang, Li-xin Hu

ABSTRACT

The drug release profiles of poly(dimer acid-dodecanedioic acid) P(DA-DDDA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The biocompatibility of P(DA-DDDA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(DA-DDDA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (31 ± 1.5 days) compared to plain subcutaneous injection of ADM (7 ± 0.9 days). The studies suggest that P(DA-DDDA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors. More... »

PAGES

1515-1520

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10856-007-0126-1

DOI

http://dx.doi.org/10.1007/s10856-007-0126-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026334154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17387591


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