Release of copper complexes from a nanostructured sol–gel titania for cancer treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-13

AUTHORS

Tessy López, Emma Ortiz-Islas, Patricia Guevara, Francisco Rodríguez-Reinoso, Esteban Gómez, José Luis Cuevas, Octavio Novaro

ABSTRACT

Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-TiO2) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-TiO2 materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg mL−1) of each copper complex, those loaded on titania (Cu/F-TiO2), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-TiO2 materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-TiO2 materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on TiO2 had higher toxic effect than cis-Pt. More... »

PAGES

2410-2421

References to SciGraph publications

  • 2007-12-01. Nanotechnology-based drug delivery systems in JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
  • 2011-12-13. Sol–gel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system in JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1007/s10853-014-8796-9

    DOI

    http://dx.doi.org/10.1007/s10853-014-8796-9

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