Crystal solvates and polymorphs of N-(3-methylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl)cytisine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06

AUTHORS

B. Tashkhodjave, K. K. Turgunov, A. G. Tojiboev, U. S. Makhmudov, T. F. Ibragimov, V. A. Saprykina, Kh. M. Shakhidoyatov

ABSTRACT

A polymorphs, crystallohydrate and crystallosolvates of N-(3-methylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl)cytisine, C16H19N5O2S2, with chloroform, methanol, benzene have been obtained and crystal structures have been determined by the method of single crystal X-ray diffraction. In the investigated crystals N-(3-methylthio-1,2,4-thiadiazol-5-yl-aminocarbonylmethyl)cytisine have taken four types of conformation due to intra-molecular rotations around N–C and C–C bonds. So free rotations in the molecule assisted in formation a different crystallosolvates and polymorphs depending on nature of solvents. The thermal decomposition of the hydrate and methanol solvated crystals was studied by means of a TG-DSC. More... »

PAGES

71-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10847-007-9394-0

DOI

http://dx.doi.org/10.1007/s10847-007-9394-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025817409


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