Percutaneous left atrial appendage closure in patients with primary hemostasis disorders and atrial fibrillation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-25

AUTHORS

Nicolas Dognin, Erwan Salaun, Catherine Champagne, Guillaume Domain, Gilles O’Hara, François Philippon, Jean-Michel Paradis, Laurent Faroux, Jonathan Beaudoin, Kim O’Connor, Mathieu Bernier, Josep Rodés-Cabau, Jean Champagne

ABSTRACT

Background or purposeWe report our single-center experience with percutaneous left atrial appendage closure (LAAC) in patients with non-valvular atrial fibrillation (NVAF) and primary hemostasis disorders (HD).MethodsConsecutive patients with primary HD who underwent a percutaneous LAAC were included. Baseline characteristics, procedural data, and clinical outcomes were prospectively collected and compared with the overall LAAC cohort without HD.ResultsSince 2013, among 229 LAAC, 17 patients (7%) had a primary HD: thrombocytopenia (n = 5), myelodysplastic syndrome (n = 6), von Willebrand syndrome (n = 4), type A hemophilia (n = 1), and dysfibrinogenemia (n = 1). The HD population’s age ranged from 61 to 87 years, and the median CHA2DS2VASc was 5. Periprocedural plasmatic management was required in 47% of patients. The immediate LAAC implantation success rate was 100%. Patients received a direct oral anticoagulant (DOA) (n = 9), dual antiplatelet (n = 6), aspirin (n = 1), or no therapy (n = 1) during the first six postoperative weeks, followed with single antiplatelet (n = 16) or no therapy (n = 1) during lifelong. After 20 months, the technical success rate and procedural success rate were 100% and 94%. Zero device-/procedure-related complication and only one life-threatening bleeding occurred. Compared to patients without HD (n = 212), a baseline history of bleeding was less frequent (53% vs 91%, p < 0.001), and more patients received a perioperative blood transfusion (47% vs 4%, p < 0.001) in the HD group. The efficacy and safety outcomes did not differ between HD and non-HD cohorts.ConclusionsPercutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up.Graphical abstractPercutaneous left atrial appendage closure in patients with atrial fibrillation and primary hemostasis disorders. The percutaneous LAAC in primary hemostasis disorders and AF carriers requires a multidisciplinary approach. Cardiologist, anesthesiologist, and hematologist discussion is a cornerstone to assess anticoagulant contraindication, LAAC feasibility, periprocedural management, and follow-up (high). This multidisciplinary care is illustrated by the case of a 61-year-old male with hemophilia type A and recurrent hemarthrosis. Pre-LAAC assessment confirmed procedural indication and cactus LAA anatomy (left). After plasmatic management with factor VIII infusion, a WATCHMAN™ no. 21 was successfully implanted (middle). During follow-up, without antithrombotic regime, no ischemic or hemorrhagic complication occurred (right). LAA, left atrial appendage; LAAC, left atrial appendage closure; TEE, transesophageal echocardiography. Percutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up. More... »

PAGES

1-13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10840-021-01073-0

DOI

http://dx.doi.org/10.1007/s10840-021-01073-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1143056625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34822043


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dognin", 
        "givenName": "Nicolas", 
        "id": "sg:person.015372763644.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015372763644.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salaun", 
        "givenName": "Erwan", 
        "id": "sg:person.01305556310.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305556310.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Champagne", 
        "givenName": "Catherine", 
        "id": "sg:person.014133225377.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014133225377.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Domain", 
        "givenName": "Guillaume", 
        "id": "sg:person.016021500340.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016021500340.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Hara", 
        "givenName": "Gilles", 
        "id": "sg:person.01207415712.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207415712.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philippon", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.01073167312.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073167312.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paradis", 
        "givenName": "Jean-Michel", 
        "id": "sg:person.0777357754.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777357754.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faroux", 
        "givenName": "Laurent", 
        "id": "sg:person.01332773377.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332773377.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaudoin", 
        "givenName": "Jonathan", 
        "id": "sg:person.01246737301.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246737301.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Connor", 
        "givenName": "Kim", 
        "id": "sg:person.01342307601.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342307601.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernier", 
        "givenName": "Mathieu", 
        "id": "sg:person.0676567035.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676567035.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rod\u00e9s-Cabau", 
        "givenName": "Josep", 
        "id": "sg:person.01234573672.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234573672.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.421142.0", 
          "name": [
            "Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Qu\u00e9bec, 2725 Chemin de Sainte-Foy, G1V 4G5, Qu\u00e9bec City, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Champagne", 
        "givenName": "Jean", 
        "id": "sg:person.01043354457.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043354457.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11239-018-1792-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110748734", 
          "https://doi.org/10.1007/s11239-018-1792-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-020-02097-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1126388045", 
          "https://doi.org/10.1007/s11239-020-02097-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-020-02205-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1128838152", 
          "https://doi.org/10.1007/s11239-020-02205-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-11-25", 
    "datePublishedReg": "2021-11-25", 
    "description": "Background or purposeWe report our single-center experience with percutaneous left atrial appendage closure (LAAC) in patients with non-valvular atrial fibrillation (NVAF) and primary hemostasis disorders (HD).MethodsConsecutive patients with primary HD who underwent a percutaneous LAAC were included. Baseline characteristics, procedural data, and clinical outcomes were prospectively collected and compared with the overall LAAC cohort without HD.ResultsSince 2013, among 229 LAAC, 17 patients (7%) had a primary HD: thrombocytopenia (n\u2009=\u20095), myelodysplastic syndrome (n\u2009=\u20096), von Willebrand syndrome (n\u2009=\u20094), type A hemophilia (n\u2009=\u20091), and dysfibrinogenemia (n\u2009=\u20091). The HD population\u2019s age ranged from 61 to 87\u00a0years, and the median CHA2DS2VASc was 5. Periprocedural plasmatic management was required in 47% of patients. The immediate LAAC implantation success rate was 100%. Patients received a direct oral anticoagulant (DOA) (n\u2009=\u20099), dual antiplatelet (n\u2009=\u20096), aspirin (n\u2009=\u20091), or no therapy (n\u2009=\u20091) during the first six postoperative weeks, followed with single antiplatelet (n\u2009=\u200916) or no therapy (n\u2009=\u20091) during lifelong. After 20\u00a0months, the technical success rate and procedural success rate were 100% and 94%. Zero device-/procedure-related complication and only one life-threatening bleeding occurred. Compared to patients without HD (n\u2009=\u2009212), a baseline history of bleeding was less frequent (53% vs 91%, p\u2009<\u20090.001), and more patients received a perioperative blood transfusion (47% vs 4%, p\u2009<\u20090.001) in the HD group. The efficacy and safety outcomes did not differ between HD and non-HD cohorts.ConclusionsPercutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up.Graphical abstractPercutaneous left atrial appendage closure in patients with atrial fibrillation and primary hemostasis disorders. The percutaneous LAAC in primary hemostasis disorders and AF carriers requires a multidisciplinary approach. Cardiologist, anesthesiologist, and hematologist discussion is a cornerstone to assess anticoagulant contraindication, LAAC feasibility, periprocedural management, and follow-up (high). This multidisciplinary care is illustrated by the case of a 61-year-old male with hemophilia type A and recurrent hemarthrosis. Pre-LAAC assessment confirmed procedural indication and cactus LAA anatomy (left). After plasmatic management with factor VIII infusion, a WATCHMAN\u2122 no. 21 was successfully implanted (middle). During follow-up, without antithrombotic regime, no ischemic or hemorrhagic complication occurred (right). LAA, left atrial appendage; LAAC, left atrial appendage closure; TEE, transesophageal echocardiography.\u00a0Percutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10840-021-01073-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116996", 
        "issn": [
          "1383-875X", 
          "1573-725X"
        ], 
        "name": "Journal of Interventional Cardiac Electrophysiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "left atrial appendage closure", 
      "percutaneous left atrial appendage closure", 
      "primary hemostasis disorders", 
      "atrial appendage closure", 
      "non-valvular atrial fibrillation", 
      "direct oral anticoagulants", 
      "appendage closure", 
      "hemostasis disorders", 
      "atrial fibrillation", 
      "HD carriers", 
      "success rate", 
      "perioperative blood transfusion", 
      "single-center experience", 
      "procedural success rate", 
      "life-threatening bleeding", 
      "technical success rate", 
      "von Willebrand syndrome", 
      "factor VIII infusions", 
      "hemophilia type A", 
      "implantation success rate", 
      "single antiplatelet", 
      "MethodsConsecutive patients", 
      "oral anticoagulants", 
      "periprocedural management", 
      "hemorrhagic complications", 
      "baseline characteristics", 
      "dual antiplatelet", 
      "procedural indications", 
      "more patients", 
      "blood transfusion", 
      "multidisciplinary care", 
      "clinical outcomes", 
      "postoperative week", 
      "baseline history", 
      "antithrombotic regimes", 
      "procedural data", 
      "myelodysplastic syndrome", 
      "recurrent hemarthrosis", 
      "transesophageal echocardiography", 
      "HD group", 
      "atrial appendage", 
      "safety outcomes", 
      "patients", 
      "LAA anatomy", 
      "population ages", 
      "fibrillation", 
      "multidisciplinary approach", 
      "disorders", 
      "bleeding", 
      "antiplatelet", 
      "complications", 
      "syndrome", 
      "type A", 
      "therapy", 
      "cohort", 
      "stroke", 
      "prevention", 
      "midterm", 
      "outcomes", 
      "age", 
      "closure", 
      "CHA2DS2VASc", 
      "thrombocytopenia", 
      "transfusion", 
      "hemarthrosis", 
      "contraindications", 
      "echocardiography", 
      "aspirin", 
      "anticoagulants", 
      "infusion", 
      "anesthesiologists", 
      "PurposeWe", 
      "hemophilia", 
      "population", 
      "management", 
      "weeks", 
      "months", 
      "care", 
      "efficacy", 
      "dysfibrinogenemia", 
      "rate", 
      "males", 
      "anatomy", 
      "indications", 
      "No. 21", 
      "group", 
      "TEE", 
      "years", 
      "carriers", 
      "cornerstone", 
      "assessment", 
      "Watchman", 
      "history", 
      "cases", 
      "appendages", 
      "background", 
      "experience", 
      "data", 
      "feasibility", 
      "Lifelong", 
      "characteristics", 
      "discussion", 
      "approach", 
      "devices", 
      "regime"
    ], 
    "name": "Percutaneous left atrial appendage closure in patients with primary hemostasis disorders and atrial fibrillation", 
    "pagination": "1-13", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1143056625"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10840-021-01073-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34822043"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10840-021-01073-0", 
      "https://app.dimensions.ai/details/publication/pub.1143056625"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_894.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10840-021-01073-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10840-021-01073-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10840-021-01073-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10840-021-01073-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10840-021-01073-0'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      22 PREDICATES      132 URIs      121 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10840-021-01073-0 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Ne89d3571410a4a48a9e4b217b914339e
4 schema:citation sg:pub.10.1007/s11239-018-1792-1
5 sg:pub.10.1007/s11239-020-02097-5
6 sg:pub.10.1007/s11239-020-02205-5
7 schema:datePublished 2021-11-25
8 schema:datePublishedReg 2021-11-25
9 schema:description Background or purposeWe report our single-center experience with percutaneous left atrial appendage closure (LAAC) in patients with non-valvular atrial fibrillation (NVAF) and primary hemostasis disorders (HD).MethodsConsecutive patients with primary HD who underwent a percutaneous LAAC were included. Baseline characteristics, procedural data, and clinical outcomes were prospectively collected and compared with the overall LAAC cohort without HD.ResultsSince 2013, among 229 LAAC, 17 patients (7%) had a primary HD: thrombocytopenia (n = 5), myelodysplastic syndrome (n = 6), von Willebrand syndrome (n = 4), type A hemophilia (n = 1), and dysfibrinogenemia (n = 1). The HD population’s age ranged from 61 to 87 years, and the median CHA2DS2VASc was 5. Periprocedural plasmatic management was required in 47% of patients. The immediate LAAC implantation success rate was 100%. Patients received a direct oral anticoagulant (DOA) (n = 9), dual antiplatelet (n = 6), aspirin (n = 1), or no therapy (n = 1) during the first six postoperative weeks, followed with single antiplatelet (n = 16) or no therapy (n = 1) during lifelong. After 20 months, the technical success rate and procedural success rate were 100% and 94%. Zero device-/procedure-related complication and only one life-threatening bleeding occurred. Compared to patients without HD (n = 212), a baseline history of bleeding was less frequent (53% vs 91%, p < 0.001), and more patients received a perioperative blood transfusion (47% vs 4%, p < 0.001) in the HD group. The efficacy and safety outcomes did not differ between HD and non-HD cohorts.ConclusionsPercutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up.Graphical abstractPercutaneous left atrial appendage closure in patients with atrial fibrillation and primary hemostasis disorders. The percutaneous LAAC in primary hemostasis disorders and AF carriers requires a multidisciplinary approach. Cardiologist, anesthesiologist, and hematologist discussion is a cornerstone to assess anticoagulant contraindication, LAAC feasibility, periprocedural management, and follow-up (high). This multidisciplinary care is illustrated by the case of a 61-year-old male with hemophilia type A and recurrent hemarthrosis. Pre-LAAC assessment confirmed procedural indication and cactus LAA anatomy (left). After plasmatic management with factor VIII infusion, a WATCHMAN™ no. 21 was successfully implanted (middle). During follow-up, without antithrombotic regime, no ischemic or hemorrhagic complication occurred (right). LAA, left atrial appendage; LAAC, left atrial appendage closure; TEE, transesophageal echocardiography. Percutaneous LAAC in primary HD carriers appeared as safe and as effective as in overall LAAC population for stroke and bleeding prevention at midterm follow-up.
10 schema:genre article
11 schema:inLanguage en
12 schema:isAccessibleForFree false
13 schema:isPartOf sg:journal.1116996
14 schema:keywords CHA2DS2VASc
15 HD carriers
16 HD group
17 LAA anatomy
18 Lifelong
19 MethodsConsecutive patients
20 No. 21
21 PurposeWe
22 TEE
23 Watchman
24 age
25 anatomy
26 anesthesiologists
27 anticoagulants
28 antiplatelet
29 antithrombotic regimes
30 appendage closure
31 appendages
32 approach
33 aspirin
34 assessment
35 atrial appendage
36 atrial appendage closure
37 atrial fibrillation
38 background
39 baseline characteristics
40 baseline history
41 bleeding
42 blood transfusion
43 care
44 carriers
45 cases
46 characteristics
47 clinical outcomes
48 closure
49 cohort
50 complications
51 contraindications
52 cornerstone
53 data
54 devices
55 direct oral anticoagulants
56 discussion
57 disorders
58 dual antiplatelet
59 dysfibrinogenemia
60 echocardiography
61 efficacy
62 experience
63 factor VIII infusions
64 feasibility
65 fibrillation
66 group
67 hemarthrosis
68 hemophilia
69 hemophilia type A
70 hemorrhagic complications
71 hemostasis disorders
72 history
73 implantation success rate
74 indications
75 infusion
76 left atrial appendage closure
77 life-threatening bleeding
78 males
79 management
80 midterm
81 months
82 more patients
83 multidisciplinary approach
84 multidisciplinary care
85 myelodysplastic syndrome
86 non-valvular atrial fibrillation
87 oral anticoagulants
88 outcomes
89 patients
90 percutaneous left atrial appendage closure
91 perioperative blood transfusion
92 periprocedural management
93 population
94 population ages
95 postoperative week
96 prevention
97 primary hemostasis disorders
98 procedural data
99 procedural indications
100 procedural success rate
101 rate
102 recurrent hemarthrosis
103 regime
104 safety outcomes
105 single antiplatelet
106 single-center experience
107 stroke
108 success rate
109 syndrome
110 technical success rate
111 therapy
112 thrombocytopenia
113 transesophageal echocardiography
114 transfusion
115 type A
116 von Willebrand syndrome
117 weeks
118 years
119 schema:name Percutaneous left atrial appendage closure in patients with primary hemostasis disorders and atrial fibrillation
120 schema:pagination 1-13
121 schema:productId N063f64b48ddf479daf16e691492008e5
122 N11ccb63c0b234827b53851390f35ff44
123 N7b9bf75d887f4913987195dc972265f7
124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1143056625
125 https://doi.org/10.1007/s10840-021-01073-0
126 schema:sdDatePublished 2022-05-10T10:27
127 schema:sdLicense https://scigraph.springernature.com/explorer/license/
128 schema:sdPublisher Na25ac81b24d14ee9ab37c5d3d94884c9
129 schema:url https://doi.org/10.1007/s10840-021-01073-0
130 sgo:license sg:explorer/license/
131 sgo:sdDataset articles
132 rdf:type schema:ScholarlyArticle
133 N063f64b48ddf479daf16e691492008e5 schema:name pubmed_id
134 schema:value 34822043
135 rdf:type schema:PropertyValue
136 N08c34a575b4540bf9afbb5453e8c3124 rdf:first sg:person.0676567035.42
137 rdf:rest Ne9bbf2617bba4d2ea492b5eeac83efc1
138 N11ccb63c0b234827b53851390f35ff44 schema:name doi
139 schema:value 10.1007/s10840-021-01073-0
140 rdf:type schema:PropertyValue
141 N124abbbe9050480a8e9b6714dc7e1f99 rdf:first sg:person.01073167312.93
142 rdf:rest N21992d06939c4a19a5e479a86dc01217
143 N21992d06939c4a19a5e479a86dc01217 rdf:first sg:person.0777357754.17
144 rdf:rest N458b091dc92f4ff48c12167e41df7564
145 N3e29922d9e6f4caaaa6ebe31fb99159f rdf:first sg:person.016021500340.53
146 rdf:rest N9d328c2d1f8f499c9dec8b6b0b4738ae
147 N408ecc35fdbe42a2b9f0e97dffee4cb7 rdf:first sg:person.01246737301.56
148 rdf:rest N7b8fc569199a4175afab06c06ff176cf
149 N458b091dc92f4ff48c12167e41df7564 rdf:first sg:person.01332773377.09
150 rdf:rest N408ecc35fdbe42a2b9f0e97dffee4cb7
151 N4e92a0095ea34f04bfa1f3158dcf9e8e rdf:first sg:person.01305556310.45
152 rdf:rest Na246e99388814f4e8f91616bba39bf1f
153 N7b8fc569199a4175afab06c06ff176cf rdf:first sg:person.01342307601.90
154 rdf:rest N08c34a575b4540bf9afbb5453e8c3124
155 N7b9bf75d887f4913987195dc972265f7 schema:name dimensions_id
156 schema:value pub.1143056625
157 rdf:type schema:PropertyValue
158 N9d328c2d1f8f499c9dec8b6b0b4738ae rdf:first sg:person.01207415712.77
159 rdf:rest N124abbbe9050480a8e9b6714dc7e1f99
160 Na246e99388814f4e8f91616bba39bf1f rdf:first sg:person.014133225377.53
161 rdf:rest N3e29922d9e6f4caaaa6ebe31fb99159f
162 Na25ac81b24d14ee9ab37c5d3d94884c9 schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 Na6c010e481ca410886ba8c94ee04d1ee rdf:first sg:person.01043354457.41
165 rdf:rest rdf:nil
166 Ne89d3571410a4a48a9e4b217b914339e rdf:first sg:person.015372763644.42
167 rdf:rest N4e92a0095ea34f04bfa1f3158dcf9e8e
168 Ne9bbf2617bba4d2ea492b5eeac83efc1 rdf:first sg:person.01234573672.96
169 rdf:rest Na6c010e481ca410886ba8c94ee04d1ee
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
174 schema:name Cardiorespiratory Medicine and Haematology
175 rdf:type schema:DefinedTerm
176 sg:journal.1116996 schema:issn 1383-875X
177 1573-725X
178 schema:name Journal of Interventional Cardiac Electrophysiology
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.01043354457.41 schema:affiliation grid-institutes:grid.421142.0
182 schema:familyName Champagne
183 schema:givenName Jean
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043354457.41
185 rdf:type schema:Person
186 sg:person.01073167312.93 schema:affiliation grid-institutes:grid.421142.0
187 schema:familyName Philippon
188 schema:givenName François
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073167312.93
190 rdf:type schema:Person
191 sg:person.01207415712.77 schema:affiliation grid-institutes:grid.421142.0
192 schema:familyName O’Hara
193 schema:givenName Gilles
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207415712.77
195 rdf:type schema:Person
196 sg:person.01234573672.96 schema:affiliation grid-institutes:grid.421142.0
197 schema:familyName Rodés-Cabau
198 schema:givenName Josep
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234573672.96
200 rdf:type schema:Person
201 sg:person.01246737301.56 schema:affiliation grid-institutes:grid.421142.0
202 schema:familyName Beaudoin
203 schema:givenName Jonathan
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246737301.56
205 rdf:type schema:Person
206 sg:person.01305556310.45 schema:affiliation grid-institutes:grid.421142.0
207 schema:familyName Salaun
208 schema:givenName Erwan
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305556310.45
210 rdf:type schema:Person
211 sg:person.01332773377.09 schema:affiliation grid-institutes:grid.421142.0
212 schema:familyName Faroux
213 schema:givenName Laurent
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332773377.09
215 rdf:type schema:Person
216 sg:person.01342307601.90 schema:affiliation grid-institutes:grid.421142.0
217 schema:familyName O’Connor
218 schema:givenName Kim
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342307601.90
220 rdf:type schema:Person
221 sg:person.014133225377.53 schema:affiliation grid-institutes:grid.421142.0
222 schema:familyName Champagne
223 schema:givenName Catherine
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014133225377.53
225 rdf:type schema:Person
226 sg:person.015372763644.42 schema:affiliation grid-institutes:grid.421142.0
227 schema:familyName Dognin
228 schema:givenName Nicolas
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015372763644.42
230 rdf:type schema:Person
231 sg:person.016021500340.53 schema:affiliation grid-institutes:grid.421142.0
232 schema:familyName Domain
233 schema:givenName Guillaume
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016021500340.53
235 rdf:type schema:Person
236 sg:person.0676567035.42 schema:affiliation grid-institutes:grid.421142.0
237 schema:familyName Bernier
238 schema:givenName Mathieu
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676567035.42
240 rdf:type schema:Person
241 sg:person.0777357754.17 schema:affiliation grid-institutes:grid.421142.0
242 schema:familyName Paradis
243 schema:givenName Jean-Michel
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777357754.17
245 rdf:type schema:Person
246 sg:pub.10.1007/s11239-018-1792-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110748734
247 https://doi.org/10.1007/s11239-018-1792-1
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s11239-020-02097-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1126388045
250 https://doi.org/10.1007/s11239-020-02097-5
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s11239-020-02205-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128838152
253 https://doi.org/10.1007/s11239-020-02205-5
254 rdf:type schema:CreativeWork
255 grid-institutes:grid.421142.0 schema:alternateName Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Québec, 2725 Chemin de Sainte-Foy, G1V 4G5, Québec City, Québec, Canada
256 schema:name Service de Cardiologie, Institut Universitaire de Cardiologie Et de Pneumologie de Québec, 2725 Chemin de Sainte-Foy, G1V 4G5, Québec City, Québec, Canada
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...