Impact of left ventricular lead position on the incidence of ventricular arrhythmia and clinical outcome in patients with cardiac resynchronization ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03-03

AUTHORS

Thomas Kleemann, Torsten Becker, Margit Strauss, Ngoc Dyck, Steffen Schneider, Udo Weisse, Werner Saggau, Bernd Cornelius, Günter Layer, Karlheinz Seidl

ABSTRACT

PurposeThe aim of the study was to evaluate the incidence of ventricular arrhythmia and clinical outcome in patients receiving a cardiac resynchronization therapy (CRT) depending on the left ventricular (LV) lead position.MethodsA total of 187 consecutive patients with advanced heart failure who received a CRT-implantable cardioverter defibrillator were analyzed. Forty patients (21%) had a LV lead in the anterior/apical (anterior) and 147 patients (79%) in the posterior/posterolateral (posterior) region. The total median follow-up time was 644 days.ResultsThe incidence of ventricular arrhythmia was 35% in patients with an anterior LV lead versus 30% in patients with a posterior LV lead (p = 0.53). The 1- and 2-year mortality in the anterior LV lead group was 19% and 22%, as compared with 0.7% and 3.2%, respectively, in the posterior LV lead group (p < 0.001). In a multivariable analysis, an anterior LV lead was independently associated with an increased mortality (hazard ratio 5.88, 95% confidence interval 2.22–16.67). The major cause of death was end-stage heart failure whereas the incidence of sudden cardiac death was not different between both groups.ConclusionsThus, biventricular pacing with an anterior LV lead seems to have no impact on the incidence of ventricular arrhythmia but may be associated with an increased mortality rate due to worsening heart failure. More... »

PAGES

109-116

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10840-010-9470-z

DOI

http://dx.doi.org/10.1007/s10840-010-9470-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015140525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20198505


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