Modelling intrinsic electrophysiological properties of ON and OFF retinal ganglion cells View Full Text


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Article Info

DATE

2011-03-23

AUTHORS

Tatiana Kameneva, Hamish Meffin, Anthony N. Burkitt

ABSTRACT

ON and OFF retinal ganglion cells (RGCs) display differences in their intrinsic electrophysiology: OFF cells maintain spontaneous activity in the absence of any input, exhibit subthreshold membrane potential oscillations, rebound excitation and burst firing; ON cells require excitatory input to drive their activity and display none of the aforementioned phenomena. The goal of this study was to identify and characterize ionic currents that explain these intrinsic electrophysiological differences between ON and OFF RGCs. A mathematical model of the electrophysiological properties of ON and OFF RGCs was constructed and validated using published patch-clamp data from isolated intact mouse retina. The model incorporates three ionic currents hypothesized to play a role in generating behaviors that are different between ON and OFF RGCs. These currents are persistent Na + , INaP, hyperpolarization-activated, Ih, and low voltage activated Ca2 + , IT, currents. Using computer simulations of Hodgkin-Huxley type neuron with a single compartment model we found two distinct sets of INaP, Ih, IT conductances that correspond to ON and OFF RGCs populations. Simulations indicated that special properties of IT explain the differences in intrinsic electrophysiology between ON and OFF RGCs examined here. The modelling shows that the maximum conductance of IT is higher in OFF than in ON cells, in agreement with recent experimental data. More... »

PAGES

547-561

References to SciGraph publications

  • 1993. NEURON — A Program for Simulation of Nerve Equations in NEURAL SYSTEMS: ANALYSIS AND MODELING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10827-011-0322-3

    DOI

    http://dx.doi.org/10.1007/s10827-011-0322-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018763995

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21431392


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