Disease-inducing potential of two leukemic cell lines in a xenografting model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-03-31

AUTHORS

D. D. Manavella, Sonia Herraiz, M. Soares, A. Buigues, A. Pellicer, J. Donnez, C. Díaz-García, M. M. Dolmans

ABSTRACT

PurposeCryopreserved ovarian tissue transplant restores ovarian function in young cancer patients after gonadotoxic treatment. However, leukemia is associated with increased risk of malignant cell transmission. We aimed to assess the tumor-inducing potential of two different leukemic cell lines when xenografted to immunodeficient mice.MethodsFifty-four female immunodeficient mice were grafted with either 100, 200, 500, 1000, and 10,000 chronic myeloid leukemia in blast crisis (BV-173) cells or relapsed acute lymphoblastic leukemia (RCH-ACV) cells, embedded inside a fibrin scaffold along with 50,000 human ovarian stromal cells. Two mice per cell line received the fibrin matrix without leukemic cells as negative controls. Clinical signs of disease were monitored for 20 weeks. Grafts, liver tissue, and masses were collected for macroscopic analysis and gene expression of BCR-ABL1 and E2A-PBX fusion transcripts present in BV-173 and RCH-ACV respectively.ResultsBV-173 cells: Mice grafted with 100, 200, or 500 cells showed no sign of disease after and were negative for BCR-ABL1 expression. Three of the 5 animals grafted with 1000 cells and all mice with 10,000 cells developed disease and showed BCR-ABL1-positive expression. RCH-ACV cells: Two out of 4 mice grafted with 100 cells developed disease and were E2A-PBX1-positive. All the animals grafted with higher cell doses showed signs of disease and all but one were E2A-PBX1-positive.ConclusionThe present work proves that the disease-inducing potential of BV-173 and RCH-ACV leukemic cells xenografted to SCID mouse peritoneum differs between cell lines, depending on cell number, type, status, and cytogenetic disease profile when ovarian tissue is harvested. More... »

PAGES

1589-1600

References to SciGraph publications

  • 2004-11-04. Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia in LEUKEMIA
  • 2012-12-22. The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 2015-07-03. A new method for evaluating the risk of transferring leukemic cells with transplanted cryopreserved ovarian tissue in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 1993-05. A rodent model for testicular involvement in acute lymphoblastic leukaemia. in BRITISH JOURNAL OF CANCER
  • 2012-05-31. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 1998-08-19. Differential growth patterns in SCID mice of patient-derived chronic myelogenous leukemias in BONE MARROW TRANSPLANTATION
  • 2013-11-25. First step in developing a 3D biodegradable fibrin scaffold for an artificial ovary in JOURNAL OF OVARIAN RESEARCH
  • 2009-12-29. Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2015-02-04. Is transplantation of a few leukemic cells inside an artificial ovary able to induce leukemia in an experimental model? in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 2018-09-25. Cryopreservation and transplantation of ovarian tissue: results from one center in the USA in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 2016-04-07. Acute myeloid leukemia presenting with complete paraplegia and bilateral total blindness due to central nervous system involvement in SPINAL CORD SERIES AND CASES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10815-021-02169-2

    DOI

    http://dx.doi.org/10.1007/s10815-021-02169-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1136786601

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33786735


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Neolife-Medicina y Cirug\u00eda Reproductiva, Brasilia 760, 1434, Asunci\u00f3n, Paraguay", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "P\u00f4le de Recherche en Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium", 
                "Neolife-Medicina y Cirug\u00eda Reproductiva, Brasilia 760, 1434, Asunci\u00f3n, Paraguay"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manavella", 
            "givenName": "D. D.", 
            "id": "sg:person.013577047542.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013577047542.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.84393.35", 
              "name": [
                "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herraiz", 
            "givenName": "Sonia", 
            "id": "sg:person.0725244145.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725244145.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "P\u00f4le de Recherche en Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.7942.8", 
              "name": [
                "P\u00f4le de Recherche en Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soares", 
            "givenName": "M.", 
            "id": "sg:person.01104531665.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104531665.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.84393.35", 
              "name": [
                "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buigues", 
            "givenName": "A.", 
            "id": "sg:person.011724070757.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724070757.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.84393.35", 
              "name": [
                "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pellicer", 
            "givenName": "A.", 
            "id": "sg:person.012076377472.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076377472.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Society for Research into Infertility, Brussels, Belgium", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Society for Research into Infertility, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Donnez", 
            "givenName": "J.", 
            "id": "sg:person.0664042671.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664042671.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Reproductive Health, UCL, WC1E 6AU, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "IVI Foundation-Instituto de Investigaci\u00f3n Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain", 
                "IVI London, IVIRMA Global, W1G 9RQ, London, UK", 
                "Department of Reproductive Health, UCL, WC1E 6AU, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u00edaz-Garc\u00eda", 
            "givenName": "C.", 
            "id": "sg:person.01242775100.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242775100.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.48769.34", 
              "name": [
                "P\u00f4le de Recherche en Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium", 
                "Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dolmans", 
            "givenName": "M. M.", 
            "id": "sg:person.01237246247.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237246247.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/scsandc.2015.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045479505", 
              "https://doi.org/10.1038/scsandc.2015.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-018-1315-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107226577", 
              "https://doi.org/10.1007/s10815-018-1315-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8722-2-51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044534826", 
              "https://doi.org/10.1186/1756-8722-2-51"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-2215-6-83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044746727", 
              "https://doi.org/10.1186/1757-2215-6-83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-015-0512-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025254984", 
              "https://doi.org/10.1007/s10815-015-0512-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-012-9786-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043543790", 
              "https://doi.org/10.1007/s10815-012-9786-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012422677", 
              "https://doi.org/10.1038/sj.leu.2403540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020837277", 
              "https://doi.org/10.1038/bjc.1993.166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1701343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006444538", 
              "https://doi.org/10.1038/sj.bmt.1701343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-012-9912-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040768139", 
              "https://doi.org/10.1007/s10815-012-9912-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-015-0438-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012659560", 
              "https://doi.org/10.1007/s10815-015-0438-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-03-31", 
        "datePublishedReg": "2021-03-31", 
        "description": "PurposeCryopreserved ovarian tissue transplant restores ovarian function in young cancer patients after gonadotoxic treatment. However, leukemia is associated with increased risk of malignant cell transmission. We aimed to assess the tumor-inducing potential of two different leukemic cell lines when xenografted to immunodeficient mice.MethodsFifty-four female immunodeficient mice were grafted with either 100, 200, 500, 1000, and 10,000 chronic myeloid leukemia in blast crisis (BV-173) cells or relapsed acute lymphoblastic leukemia (RCH-ACV) cells, embedded inside a fibrin scaffold along with 50,000 human ovarian stromal cells. Two mice per cell line received the fibrin matrix without leukemic cells as negative controls. Clinical signs of disease were monitored for 20 weeks. Grafts, liver tissue, and masses were collected for macroscopic analysis and gene expression of BCR-ABL1 and E2A-PBX fusion transcripts present in BV-173 and RCH-ACV respectively.ResultsBV-173 cells: Mice grafted with 100, 200, or 500 cells showed no sign of disease after and were negative for BCR-ABL1 expression. Three of the 5 animals grafted with 1000 cells and all mice with 10,000 cells developed disease and showed BCR-ABL1-positive expression. RCH-ACV cells: Two out of 4 mice grafted with 100 cells developed disease and were E2A-PBX1-positive. All the animals grafted with higher cell doses showed signs of disease and all but one were E2A-PBX1-positive.ConclusionThe present work proves that the disease-inducing potential of BV-173 and RCH-ACV leukemic cells xenografted to SCID mouse peritoneum differs between cell lines, depending on cell number, type, status, and cytogenetic disease profile when ovarian tissue is harvested.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10815-021-02169-2", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6951270", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1095018", 
            "issn": [
              "1058-0468", 
              "1573-7330"
            ], 
            "name": "Journal of Assisted Reproduction and Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "38"
          }
        ], 
        "keywords": [
          "signs of disease", 
          "leukemic cell lines", 
          "BCR-ABL1", 
          "leukemic cells", 
          "cell lines", 
          "ovarian tissue transplants", 
          "tumor-inducing potential", 
          "acute lymphoblastic leukemia cells", 
          "young cancer patients", 
          "ovarian stromal cells", 
          "human ovarian stromal cells", 
          "chronic myeloid leukemia", 
          "different leukemic cell lines", 
          "E2A-PBX1", 
          "disease-inducing potential", 
          "lymphoblastic leukemia cells", 
          "BCR-ABL1 expression", 
          "higher cell doses", 
          "BV-173", 
          "blast crisis cells", 
          "malignant cell transmission", 
          "gonadotoxic treatment", 
          "ovarian function", 
          "cancer patients", 
          "clinical signs", 
          "myeloid leukemia", 
          "immunodeficient mice", 
          "cell doses", 
          "tissue transplants", 
          "ovarian tissue", 
          "xenografting model", 
          "positive expression", 
          "disease profile", 
          "liver tissue", 
          "stromal cells", 
          "mice", 
          "disease", 
          "mouse peritoneum", 
          "leukemia cells", 
          "fusion transcripts", 
          "cell number", 
          "cell transmission", 
          "leukemia", 
          "negative control", 
          "fibrin matrix", 
          "crisis cells", 
          "signs", 
          "cells", 
          "tissue", 
          "animals", 
          "expression", 
          "RCH-ACV", 
          "gene expression", 
          "patients", 
          "transplant", 
          "graft", 
          "peritoneum", 
          "doses", 
          "weeks", 
          "treatment", 
          "risk", 
          "fibrin", 
          "status", 
          "macroscopic analysis", 
          "lines", 
          "potential", 
          "control", 
          "transcripts", 
          "profile", 
          "transmission", 
          "mass", 
          "function", 
          "number", 
          "types", 
          "analysis", 
          "model", 
          "present work", 
          "work", 
          "matrix", 
          "PurposeCryopreserved ovarian tissue transplant", 
          "MethodsFifty-four female immunodeficient mice", 
          "female immunodeficient mice", 
          "E2A-PBX fusion transcripts", 
          "RCH-ACV leukemic cells", 
          "SCID mouse peritoneum", 
          "cytogenetic disease profile"
        ], 
        "name": "Disease-inducing potential of two leukemic cell lines in a xenografting model", 
        "pagination": "1589-1600", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1136786601"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10815-021-02169-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33786735"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10815-021-02169-2", 
          "https://app.dimensions.ai/details/publication/pub.1136786601"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T19:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_878.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10815-021-02169-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10815-021-02169-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10815-021-02169-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10815-021-02169-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10815-021-02169-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    261 TRIPLES      22 PREDICATES      123 URIs      104 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10815-021-02169-2 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N0f150bd63dad407d93fe92423c812291
    4 schema:citation sg:pub.10.1007/s10815-012-9786-y
    5 sg:pub.10.1007/s10815-012-9912-x
    6 sg:pub.10.1007/s10815-015-0438-x
    7 sg:pub.10.1007/s10815-015-0512-4
    8 sg:pub.10.1007/s10815-018-1315-1
    9 sg:pub.10.1038/bjc.1993.166
    10 sg:pub.10.1038/scsandc.2015.35
    11 sg:pub.10.1038/sj.bmt.1701343
    12 sg:pub.10.1038/sj.leu.2403540
    13 sg:pub.10.1186/1756-8722-2-51
    14 sg:pub.10.1186/1757-2215-6-83
    15 schema:datePublished 2021-03-31
    16 schema:datePublishedReg 2021-03-31
    17 schema:description PurposeCryopreserved ovarian tissue transplant restores ovarian function in young cancer patients after gonadotoxic treatment. However, leukemia is associated with increased risk of malignant cell transmission. We aimed to assess the tumor-inducing potential of two different leukemic cell lines when xenografted to immunodeficient mice.MethodsFifty-four female immunodeficient mice were grafted with either 100, 200, 500, 1000, and 10,000 chronic myeloid leukemia in blast crisis (BV-173) cells or relapsed acute lymphoblastic leukemia (RCH-ACV) cells, embedded inside a fibrin scaffold along with 50,000 human ovarian stromal cells. Two mice per cell line received the fibrin matrix without leukemic cells as negative controls. Clinical signs of disease were monitored for 20 weeks. Grafts, liver tissue, and masses were collected for macroscopic analysis and gene expression of BCR-ABL1 and E2A-PBX fusion transcripts present in BV-173 and RCH-ACV respectively.ResultsBV-173 cells: Mice grafted with 100, 200, or 500 cells showed no sign of disease after and were negative for BCR-ABL1 expression. Three of the 5 animals grafted with 1000 cells and all mice with 10,000 cells developed disease and showed BCR-ABL1-positive expression. RCH-ACV cells: Two out of 4 mice grafted with 100 cells developed disease and were E2A-PBX1-positive. All the animals grafted with higher cell doses showed signs of disease and all but one were E2A-PBX1-positive.ConclusionThe present work proves that the disease-inducing potential of BV-173 and RCH-ACV leukemic cells xenografted to SCID mouse peritoneum differs between cell lines, depending on cell number, type, status, and cytogenetic disease profile when ovarian tissue is harvested.
    18 schema:genre article
    19 schema:inLanguage en
    20 schema:isAccessibleForFree false
    21 schema:isPartOf N8bc70753215f4ebc8131593b2663a02f
    22 Nf19486cf5f7a4d19a961325688b9ffa5
    23 sg:journal.1095018
    24 schema:keywords BCR-ABL1
    25 BCR-ABL1 expression
    26 BV-173
    27 E2A-PBX fusion transcripts
    28 E2A-PBX1
    29 MethodsFifty-four female immunodeficient mice
    30 PurposeCryopreserved ovarian tissue transplant
    31 RCH-ACV
    32 RCH-ACV leukemic cells
    33 SCID mouse peritoneum
    34 acute lymphoblastic leukemia cells
    35 analysis
    36 animals
    37 blast crisis cells
    38 cancer patients
    39 cell doses
    40 cell lines
    41 cell number
    42 cell transmission
    43 cells
    44 chronic myeloid leukemia
    45 clinical signs
    46 control
    47 crisis cells
    48 cytogenetic disease profile
    49 different leukemic cell lines
    50 disease
    51 disease profile
    52 disease-inducing potential
    53 doses
    54 expression
    55 female immunodeficient mice
    56 fibrin
    57 fibrin matrix
    58 function
    59 fusion transcripts
    60 gene expression
    61 gonadotoxic treatment
    62 graft
    63 higher cell doses
    64 human ovarian stromal cells
    65 immunodeficient mice
    66 leukemia
    67 leukemia cells
    68 leukemic cell lines
    69 leukemic cells
    70 lines
    71 liver tissue
    72 lymphoblastic leukemia cells
    73 macroscopic analysis
    74 malignant cell transmission
    75 mass
    76 matrix
    77 mice
    78 model
    79 mouse peritoneum
    80 myeloid leukemia
    81 negative control
    82 number
    83 ovarian function
    84 ovarian stromal cells
    85 ovarian tissue
    86 ovarian tissue transplants
    87 patients
    88 peritoneum
    89 positive expression
    90 potential
    91 present work
    92 profile
    93 risk
    94 signs
    95 signs of disease
    96 status
    97 stromal cells
    98 tissue
    99 tissue transplants
    100 transcripts
    101 transmission
    102 transplant
    103 treatment
    104 tumor-inducing potential
    105 types
    106 weeks
    107 work
    108 xenografting model
    109 young cancer patients
    110 schema:name Disease-inducing potential of two leukemic cell lines in a xenografting model
    111 schema:pagination 1589-1600
    112 schema:productId N1f1faf5e226e4204a261fd27b0f96184
    113 N92a445802deb49c1a9618910a5b1a523
    114 Nd76cd5c2d6384ef892dac6377463e7a5
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136786601
    116 https://doi.org/10.1007/s10815-021-02169-2
    117 schema:sdDatePublished 2022-01-01T19:01
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher Ndda5e3ad2f2e4677afbd4bd6186151b2
    120 schema:url https://doi.org/10.1007/s10815-021-02169-2
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N0f150bd63dad407d93fe92423c812291 rdf:first sg:person.013577047542.74
    125 rdf:rest N3ab0088997f64c2eb013a300e115f0c9
    126 N1f1faf5e226e4204a261fd27b0f96184 schema:name doi
    127 schema:value 10.1007/s10815-021-02169-2
    128 rdf:type schema:PropertyValue
    129 N3ab0088997f64c2eb013a300e115f0c9 rdf:first sg:person.0725244145.42
    130 rdf:rest Nfeb185bba2df4e2fa32f24ac17527ea9
    131 N44c1881a01e148a1a61798306175e106 rdf:first sg:person.01237246247.42
    132 rdf:rest rdf:nil
    133 N8bc70753215f4ebc8131593b2663a02f schema:volumeNumber 38
    134 rdf:type schema:PublicationVolume
    135 N8c4327f63eb34239aed6234df3910b6f rdf:first sg:person.01242775100.22
    136 rdf:rest N44c1881a01e148a1a61798306175e106
    137 N92a445802deb49c1a9618910a5b1a523 schema:name dimensions_id
    138 schema:value pub.1136786601
    139 rdf:type schema:PropertyValue
    140 Nada4ea9888a54242a20c09a0fe71ccbf rdf:first sg:person.0664042671.14
    141 rdf:rest N8c4327f63eb34239aed6234df3910b6f
    142 Nb0785b7e19f04ce38eb13cc780bc552f rdf:first sg:person.011724070757.34
    143 rdf:rest Nf347b2d09fa7434093251796b98fa5b8
    144 Nd76cd5c2d6384ef892dac6377463e7a5 schema:name pubmed_id
    145 schema:value 33786735
    146 rdf:type schema:PropertyValue
    147 Ndda5e3ad2f2e4677afbd4bd6186151b2 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 Nf19486cf5f7a4d19a961325688b9ffa5 schema:issueNumber 6
    150 rdf:type schema:PublicationIssue
    151 Nf347b2d09fa7434093251796b98fa5b8 rdf:first sg:person.012076377472.07
    152 rdf:rest Nada4ea9888a54242a20c09a0fe71ccbf
    153 Nfeb185bba2df4e2fa32f24ac17527ea9 rdf:first sg:person.01104531665.03
    154 rdf:rest Nb0785b7e19f04ce38eb13cc780bc552f
    155 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    156 schema:name Medical and Health Sciences
    157 rdf:type schema:DefinedTerm
    158 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Oncology and Carcinogenesis
    160 rdf:type schema:DefinedTerm
    161 sg:grant.6951270 http://pending.schema.org/fundedItem sg:pub.10.1007/s10815-021-02169-2
    162 rdf:type schema:MonetaryGrant
    163 sg:journal.1095018 schema:issn 1058-0468
    164 1573-7330
    165 schema:name Journal of Assisted Reproduction and Genetics
    166 schema:publisher Springer Nature
    167 rdf:type schema:Periodical
    168 sg:person.01104531665.03 schema:affiliation grid-institutes:grid.7942.8
    169 schema:familyName Soares
    170 schema:givenName M.
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104531665.03
    172 rdf:type schema:Person
    173 sg:person.011724070757.34 schema:affiliation grid-institutes:grid.84393.35
    174 schema:familyName Buigues
    175 schema:givenName A.
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724070757.34
    177 rdf:type schema:Person
    178 sg:person.012076377472.07 schema:affiliation grid-institutes:grid.84393.35
    179 schema:familyName Pellicer
    180 schema:givenName A.
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076377472.07
    182 rdf:type schema:Person
    183 sg:person.01237246247.42 schema:affiliation grid-institutes:grid.48769.34
    184 schema:familyName Dolmans
    185 schema:givenName M. M.
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237246247.42
    187 rdf:type schema:Person
    188 sg:person.01242775100.22 schema:affiliation grid-institutes:grid.83440.3b
    189 schema:familyName Díaz-García
    190 schema:givenName C.
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242775100.22
    192 rdf:type schema:Person
    193 sg:person.013577047542.74 schema:affiliation grid-institutes:None
    194 schema:familyName Manavella
    195 schema:givenName D. D.
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013577047542.74
    197 rdf:type schema:Person
    198 sg:person.0664042671.14 schema:affiliation grid-institutes:None
    199 schema:familyName Donnez
    200 schema:givenName J.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664042671.14
    202 rdf:type schema:Person
    203 sg:person.0725244145.42 schema:affiliation grid-institutes:grid.84393.35
    204 schema:familyName Herraiz
    205 schema:givenName Sonia
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725244145.42
    207 rdf:type schema:Person
    208 sg:pub.10.1007/s10815-012-9786-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043543790
    209 https://doi.org/10.1007/s10815-012-9786-y
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10815-012-9912-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040768139
    212 https://doi.org/10.1007/s10815-012-9912-x
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s10815-015-0438-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012659560
    215 https://doi.org/10.1007/s10815-015-0438-x
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s10815-015-0512-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025254984
    218 https://doi.org/10.1007/s10815-015-0512-4
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/s10815-018-1315-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107226577
    221 https://doi.org/10.1007/s10815-018-1315-1
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/bjc.1993.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020837277
    224 https://doi.org/10.1038/bjc.1993.166
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/scsandc.2015.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045479505
    227 https://doi.org/10.1038/scsandc.2015.35
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/sj.bmt.1701343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006444538
    230 https://doi.org/10.1038/sj.bmt.1701343
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/sj.leu.2403540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012422677
    233 https://doi.org/10.1038/sj.leu.2403540
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1186/1756-8722-2-51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044534826
    236 https://doi.org/10.1186/1756-8722-2-51
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1186/1757-2215-6-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044746727
    239 https://doi.org/10.1186/1757-2215-6-83
    240 rdf:type schema:CreativeWork
    241 grid-institutes:None schema:alternateName Neolife-Medicina y Cirugía Reproductiva, Brasilia 760, 1434, Asunción, Paraguay
    242 Society for Research into Infertility, Brussels, Belgium
    243 schema:name Neolife-Medicina y Cirugía Reproductiva, Brasilia 760, 1434, Asunción, Paraguay
    244 Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium
    245 Society for Research into Infertility, Brussels, Belgium
    246 rdf:type schema:Organization
    247 grid-institutes:grid.48769.34 schema:alternateName Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium
    248 schema:name Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium
    249 Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium
    250 rdf:type schema:Organization
    251 grid-institutes:grid.7942.8 schema:alternateName Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium
    252 schema:name Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium
    253 rdf:type schema:Organization
    254 grid-institutes:grid.83440.3b schema:alternateName Department of Reproductive Health, UCL, WC1E 6AU, London, UK
    255 schema:name Department of Reproductive Health, UCL, WC1E 6AU, London, UK
    256 IVI Foundation-Instituto de Investigación Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain
    257 IVI London, IVIRMA Global, W1G 9RQ, London, UK
    258 rdf:type schema:Organization
    259 grid-institutes:grid.84393.35 schema:alternateName IVI Foundation-Instituto de Investigación Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain
    260 schema:name IVI Foundation-Instituto de Investigación Sanitaria Hospital La Fe (IIS La Fe), Valencia, Spain
    261 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...