Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-07

AUTHORS

R. Díaz-Peña, M. J. de los Santos, Alejandro Lucia, P. Castro-Santos

ABSTRACT

Pregnancy is a unique immunological situation in which a fetus-bearing paternal histocompatibility antigens can survive in a maternal environment without apparent rejection. To face this challenge, cells of the uterine immune system show characteristic changes in absolute number and composition during pregnancy. Particularly relevant to this process are uterine natural killer (uNK) cells and their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The main purpose of this review is to outline the current body of knowledge on the involvement of KIRs in the complications of pregnancy. Implantation depends on the invasion of embryonic trophoblast cells into maternal uterine tissue and remodeling of the uterine spiral arterioles, which is essential for placental perfusion and successful pregnancy. The proper interaction between maternal KIRs and their ligands human leukocyte antigen (HLA) class I molecules, expressed by the extravillous trophoblast cells, is crucial in this process. KIRs are a complex family that includes both activator and inhibitory receptors. The activation profile is genetically determined in each individual and leads to diverse levels of functionality for NK and T cells on engagement with specific HLA class I molecules. An association between different KIR alleles and HLA molecules has been reported in pregnancy complications, supporting the idea of a relevant role of these receptors in successful pregnancy. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10815-019-01426-9

DOI

http://dx.doi.org/10.1007/s10815-019-01426-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112607101

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30847698


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universidad Aut\u00f3noma de Chile", 
          "id": "https://www.grid.ac/institutes/grid.441837.d", 
          "name": [
            "Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain", 
            "Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Talca, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00edaz-Pe\u00f1a", 
        "givenName": "R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Valencia", 
          "id": "https://www.grid.ac/institutes/grid.5338.d", 
          "name": [
            "IVI-RMA, Fundaci\u00f3n IVI; INCLIVA, IIS La Fe, Valencia University, Valencia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de los Santos", 
        "givenName": "M. J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European University of Madrid", 
          "id": "https://www.grid.ac/institutes/grid.119375.8", 
          "name": [
            "Faculty of Sport Sciences and Instituto de Investigaci\u00f3n Hospital 12 de Octubre, Universidad Europea de Madrid, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lucia", 
        "givenName": "Alejandro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vigo", 
          "id": "https://www.grid.ac/institutes/grid.6312.6", 
          "name": [
            "Inmunolog\u00eda, Centro de Investigaciones Biom\u00e9dicas (CINBIO), Universidade de Vigo, Vigo, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro-Santos", 
        "givenName": "P.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2010.05938.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001058443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.1a0815-351r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002096646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2002.19004.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003551010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2006.763_7.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003782224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2009.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004252765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0803177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004488988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deu251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004918920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(03)81006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005058967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00709.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00709.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2011.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006014769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-010-0480-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006463048", 
          "https://doi.org/10.1007/s00251-010-0480-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-010-0480-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006463048", 
          "https://doi.org/10.1007/s00251-010-0480-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007961379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007961379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008387877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2014.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008919624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/den011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.1999.0496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013392487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imr.12323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019281099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0015-0282(01)01859-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021276431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0897.2003.00018.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023318352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2007.06.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023648430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2010.212555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023852277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00005-016-0389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026561203", 
          "https://doi.org/10.1007/s00005-016-0389-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00005-016-0389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026561203", 
          "https://doi.org/10.1007/s00005-016-0389-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00005-016-0389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026561203", 
          "https://doi.org/10.1007/s00005-016-0389-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deh483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027302894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14767050903019684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029631612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcibr1207279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029919781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/7.4.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030427186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deq341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031598899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032277388", 
          "https://doi.org/10.1038/ni.3513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.06.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034343802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.medre.2015.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035849079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2009.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036586892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2006.762_8.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038031827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humupd/dms015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039476390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.7.3859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041644181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0040009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042352238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0040009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042352238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2015.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043441559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2007.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045248164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2012.00258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045778927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2005.00550.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046745886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2005.00550.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046745886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rbmo.2016.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046904952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/aji.12453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047312519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048674861", 
          "https://doi.org/10.1038/nri3370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2007.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049258283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.11.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051744897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10815-012-9811-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052520269", 
          "https://doi.org/10.1007/s10815-012-9811-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2009.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052980659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci22991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074628799", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.4.1768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075327704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.11.6719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076969442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1601279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079351128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083095029", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/aji.12643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083739009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2017.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083889292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1601175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084779795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/aji.12684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085056279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00005-017-0474-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085437834", 
          "https://doi.org/10.1007/s00005-017-0474-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00005-017-0474-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085437834", 
          "https://doi.org/10.1007/s00005-017-0474-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-017-0988-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090602422", 
          "https://doi.org/10.1007/s00251-017-0988-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-017-0988-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090602422", 
          "https://doi.org/10.1007/s00251-017-0988-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109832851", 
          "https://doi.org/10.1038/s41586-018-0698-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109832851", 
          "https://doi.org/10.1038/s41586-018-0698-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109832851", 
          "https://doi.org/10.1038/s41586-018-0698-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-07", 
    "datePublishedReg": "2019-03-07", 
    "description": "Pregnancy is a unique immunological situation in which a fetus-bearing paternal histocompatibility antigens can survive in a maternal environment without apparent rejection. To face this challenge, cells of the uterine immune system show characteristic changes in absolute number and composition during pregnancy. Particularly relevant to this process are uterine natural killer (uNK) cells and their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The main purpose of this review is to outline the current body of knowledge on the involvement of KIRs in the complications of pregnancy. Implantation depends on the invasion of embryonic trophoblast cells into maternal uterine tissue and remodeling of the uterine spiral arterioles, which is essential for placental perfusion and successful pregnancy. The proper interaction between maternal KIRs and their ligands human leukocyte antigen (HLA) class I molecules, expressed by the extravillous trophoblast cells, is crucial in this process. KIRs are a complex family that includes both activator and inhibitory receptors. The activation profile is genetically determined in each individual and leads to diverse levels of functionality for NK and T cells on engagement with specific HLA class I molecules. An association between different KIR alleles and HLA molecules has been reported in pregnancy complications, supporting the idea of a relevant role of these receptors in successful pregnancy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10815-019-01426-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095018", 
        "issn": [
          "1058-0468", 
          "1573-7330"
        ], 
        "name": "Journal of Assisted Reproduction and Genetics", 
        "type": "Periodical"
      }
    ], 
    "name": "Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "89a2fdcd09fa456672d292f6e7b91d0c6943fd6802a9b83bd9b793d1bffa17d5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30847698"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9206495"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10815-019-01426-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112607101"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10815-019-01426-9", 
      "https://app.dimensions.ai/details/publication/pub.1112607101"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11701_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10815-019-01426-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10815-019-01426-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10815-019-01426-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10815-019-01426-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10815-019-01426-9'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      85 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10815-019-01426-9 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N0ed56abe795a4eb2974d39d6acf88afe
4 schema:citation sg:pub.10.1007/s00005-016-0389-7
5 sg:pub.10.1007/s00005-017-0474-6
6 sg:pub.10.1007/s00251-010-0480-x
7 sg:pub.10.1007/s00251-017-0988-4
8 sg:pub.10.1007/s10815-012-9811-1
9 sg:pub.10.1038/ni.3513
10 sg:pub.10.1038/nri3370
11 sg:pub.10.1038/s41586-018-0698-6
12 https://app.dimensions.ai/details/publication/pub.1074628799
13 https://app.dimensions.ai/details/publication/pub.1083095029
14 https://doi.org/10.1016/j.ajog.2007.06.033
15 https://doi.org/10.1016/j.bbrc.2003.11.153
16 https://doi.org/10.1016/j.bbrc.2007.06.125
17 https://doi.org/10.1016/j.humimm.2015.01.013
18 https://doi.org/10.1016/j.imlet.2007.09.014
19 https://doi.org/10.1016/j.it.2007.11.005
20 https://doi.org/10.1016/j.jri.2009.02.004
21 https://doi.org/10.1016/j.jri.2009.05.003
22 https://doi.org/10.1016/j.jri.2011.03.006
23 https://doi.org/10.1016/j.jri.2017.02.002
24 https://doi.org/10.1016/j.medre.2015.09.001
25 https://doi.org/10.1016/j.placenta.2009.02.009
26 https://doi.org/10.1016/j.placenta.2014.02.004
27 https://doi.org/10.1016/j.rbmo.2016.08.019
28 https://doi.org/10.1016/s0015-0282(01)01859-3
29 https://doi.org/10.1016/s0065-2776(03)81006-4
30 https://doi.org/10.1034/j.1600-065x.2002.19004.x
31 https://doi.org/10.1034/j.1600-0897.2003.00018.x
32 https://doi.org/10.1053/plac.1999.0496
33 https://doi.org/10.1056/nejmcibr1207279
34 https://doi.org/10.1093/humrep/deh483
35 https://doi.org/10.1093/humrep/den011
36 https://doi.org/10.1093/humrep/deq341
37 https://doi.org/10.1093/humrep/deu251
38 https://doi.org/10.1093/humupd/dms015
39 https://doi.org/10.1093/molehr/7.4.373
40 https://doi.org/10.1111/aji.12453
41 https://doi.org/10.1111/aji.12643
42 https://doi.org/10.1111/aji.12684
43 https://doi.org/10.1111/imr.12323
44 https://doi.org/10.1111/j.1399-0039.2005.00550.x
45 https://doi.org/10.1111/j.1399-0039.2006.762_8.x
46 https://doi.org/10.1111/j.1399-0039.2006.763_7.x
47 https://doi.org/10.1111/j.1600-0897.2009.00709.x
48 https://doi.org/10.1111/j.1749-6632.2010.05938.x
49 https://doi.org/10.1136/gut.2010.212555
50 https://doi.org/10.1172/jci22991
51 https://doi.org/10.1172/jci43998
52 https://doi.org/10.1189/jlb.1a0815-351r
53 https://doi.org/10.1371/journal.pbio.0040009
54 https://doi.org/10.1371/journal.pone.0015115
55 https://doi.org/10.3109/14767050903019684
56 https://doi.org/10.3389/fimmu.2012.00258
57 https://doi.org/10.4049/jimmunol.0803177
58 https://doi.org/10.4049/jimmunol.1601175
59 https://doi.org/10.4049/jimmunol.1601279
60 https://doi.org/10.4049/jimmunol.171.4.1768
61 https://doi.org/10.4049/jimmunol.173.11.6719
62 https://doi.org/10.4049/jimmunol.174.7.3859
63 schema:datePublished 2019-03-07
64 schema:datePublishedReg 2019-03-07
65 schema:description Pregnancy is a unique immunological situation in which a fetus-bearing paternal histocompatibility antigens can survive in a maternal environment without apparent rejection. To face this challenge, cells of the uterine immune system show characteristic changes in absolute number and composition during pregnancy. Particularly relevant to this process are uterine natural killer (uNK) cells and their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The main purpose of this review is to outline the current body of knowledge on the involvement of KIRs in the complications of pregnancy. Implantation depends on the invasion of embryonic trophoblast cells into maternal uterine tissue and remodeling of the uterine spiral arterioles, which is essential for placental perfusion and successful pregnancy. The proper interaction between maternal KIRs and their ligands human leukocyte antigen (HLA) class I molecules, expressed by the extravillous trophoblast cells, is crucial in this process. KIRs are a complex family that includes both activator and inhibitory receptors. The activation profile is genetically determined in each individual and leads to diverse levels of functionality for NK and T cells on engagement with specific HLA class I molecules. An association between different KIR alleles and HLA molecules has been reported in pregnancy complications, supporting the idea of a relevant role of these receptors in successful pregnancy.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree false
69 schema:isPartOf sg:journal.1095018
70 schema:name Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications
71 schema:pagination 1-9
72 schema:productId N0b351f696f0046838fd7a5082ea5c400
73 N1564f2ff311148938768fd0a01fd1723
74 N89336ff8101e40548b5fc9d69fa6026c
75 N98caa18f0ea648b29c7b539049d385b0
76 Na20cd1690db3435c954a640608cfc0ae
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112607101
78 https://doi.org/10.1007/s10815-019-01426-9
79 schema:sdDatePublished 2019-04-11T11:18
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N2aa7bc07b15c4e2d9d5c625dadc33495
82 schema:url https://link.springer.com/10.1007%2Fs10815-019-01426-9
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N0b351f696f0046838fd7a5082ea5c400 schema:name pubmed_id
87 schema:value 30847698
88 rdf:type schema:PropertyValue
89 N0ed56abe795a4eb2974d39d6acf88afe rdf:first Ne01bd69e0ae1485da0fda290ca32a83e
90 rdf:rest Ncdadf8c55ea84ad895fc8e1d898bd8ae
91 N1070a6fc315b4b4b969fef345cfd1689 schema:affiliation https://www.grid.ac/institutes/grid.119375.8
92 schema:familyName Lucia
93 schema:givenName Alejandro
94 rdf:type schema:Person
95 N1564f2ff311148938768fd0a01fd1723 schema:name nlm_unique_id
96 schema:value 9206495
97 rdf:type schema:PropertyValue
98 N2aa7bc07b15c4e2d9d5c625dadc33495 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N50ea5c2cb5bf4d0f9dad530d79e4b5ad schema:affiliation https://www.grid.ac/institutes/grid.6312.6
101 schema:familyName Castro-Santos
102 schema:givenName P.
103 rdf:type schema:Person
104 N527117a79033427db21d1bb39d29cb4a rdf:first N1070a6fc315b4b4b969fef345cfd1689
105 rdf:rest Nac36514b0dce45d2948655b0257299af
106 N89336ff8101e40548b5fc9d69fa6026c schema:name doi
107 schema:value 10.1007/s10815-019-01426-9
108 rdf:type schema:PropertyValue
109 N98caa18f0ea648b29c7b539049d385b0 schema:name readcube_id
110 schema:value 89a2fdcd09fa456672d292f6e7b91d0c6943fd6802a9b83bd9b793d1bffa17d5
111 rdf:type schema:PropertyValue
112 Na20cd1690db3435c954a640608cfc0ae schema:name dimensions_id
113 schema:value pub.1112607101
114 rdf:type schema:PropertyValue
115 Nac36514b0dce45d2948655b0257299af rdf:first N50ea5c2cb5bf4d0f9dad530d79e4b5ad
116 rdf:rest rdf:nil
117 Ncdadf8c55ea84ad895fc8e1d898bd8ae rdf:first Nd2341a68d7a540bd8078648897f81371
118 rdf:rest N527117a79033427db21d1bb39d29cb4a
119 Nd2341a68d7a540bd8078648897f81371 schema:affiliation https://www.grid.ac/institutes/grid.5338.d
120 schema:familyName de los Santos
121 schema:givenName M. J.
122 rdf:type schema:Person
123 Ne01bd69e0ae1485da0fda290ca32a83e schema:affiliation https://www.grid.ac/institutes/grid.441837.d
124 schema:familyName Díaz-Peña
125 schema:givenName R.
126 rdf:type schema:Person
127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
128 schema:name Medical and Health Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
131 schema:name Immunology
132 rdf:type schema:DefinedTerm
133 sg:journal.1095018 schema:issn 1058-0468
134 1573-7330
135 schema:name Journal of Assisted Reproduction and Genetics
136 rdf:type schema:Periodical
137 sg:pub.10.1007/s00005-016-0389-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026561203
138 https://doi.org/10.1007/s00005-016-0389-7
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s00005-017-0474-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085437834
141 https://doi.org/10.1007/s00005-017-0474-6
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s00251-010-0480-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006463048
144 https://doi.org/10.1007/s00251-010-0480-x
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s00251-017-0988-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090602422
147 https://doi.org/10.1007/s00251-017-0988-4
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s10815-012-9811-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052520269
150 https://doi.org/10.1007/s10815-012-9811-1
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/ni.3513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032277388
153 https://doi.org/10.1038/ni.3513
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/nri3370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048674861
156 https://doi.org/10.1038/nri3370
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/s41586-018-0698-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109832851
159 https://doi.org/10.1038/s41586-018-0698-6
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1074628799 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1083095029 schema:CreativeWork
163 https://doi.org/10.1016/j.ajog.2007.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023648430
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.bbrc.2003.11.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051744897
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.bbrc.2007.06.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034343802
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.humimm.2015.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043441559
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.imlet.2007.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049258283
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.it.2007.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045248164
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.jri.2009.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004252765
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.jri.2009.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052980659
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.jri.2011.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014769
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jri.2017.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083889292
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.medre.2015.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035849079
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.placenta.2009.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036586892
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.placenta.2014.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008919624
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.rbmo.2016.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046904952
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0015-0282(01)01859-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021276431
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0065-2776(03)81006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005058967
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1034/j.1600-065x.2002.19004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003551010
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1034/j.1600-0897.2003.00018.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023318352
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1053/plac.1999.0496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013392487
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1056/nejmcibr1207279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029919781
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/humrep/deh483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027302894
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1093/humrep/den011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010113574
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1093/humrep/deq341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031598899
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/humrep/deu251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004918920
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/humupd/dms015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039476390
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/molehr/7.4.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427186
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/aji.12453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047312519
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/aji.12643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083739009
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/aji.12684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085056279
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/imr.12323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019281099
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1399-0039.2005.00550.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046745886
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/j.1399-0039.2006.762_8.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038031827
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1111/j.1399-0039.2006.763_7.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003782224
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1600-0897.2009.00709.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907447
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/j.1749-6632.2010.05938.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001058443
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1136/gut.2010.212555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023852277
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1172/jci22991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416686
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1172/jci43998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007961379
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1189/jlb.1a0815-351r schema:sameAs https://app.dimensions.ai/details/publication/pub.1002096646
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1371/journal.pbio.0040009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042352238
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.pone.0015115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008387877
244 rdf:type schema:CreativeWork
245 https://doi.org/10.3109/14767050903019684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029631612
246 rdf:type schema:CreativeWork
247 https://doi.org/10.3389/fimmu.2012.00258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045778927
248 rdf:type schema:CreativeWork
249 https://doi.org/10.4049/jimmunol.0803177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004488988
250 rdf:type schema:CreativeWork
251 https://doi.org/10.4049/jimmunol.1601175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084779795
252 rdf:type schema:CreativeWork
253 https://doi.org/10.4049/jimmunol.1601279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079351128
254 rdf:type schema:CreativeWork
255 https://doi.org/10.4049/jimmunol.171.4.1768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075327704
256 rdf:type schema:CreativeWork
257 https://doi.org/10.4049/jimmunol.173.11.6719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076969442
258 rdf:type schema:CreativeWork
259 https://doi.org/10.4049/jimmunol.174.7.3859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041644181
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.119375.8 schema:alternateName European University of Madrid
262 schema:name Faculty of Sport Sciences and Instituto de Investigación Hospital 12 de Octubre, Universidad Europea de Madrid, Madrid, Spain
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.441837.d schema:alternateName Universidad Autónoma de Chile
265 schema:name Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile
266 Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.5338.d schema:alternateName University of Valencia
269 schema:name IVI-RMA, Fundación IVI; INCLIVA, IIS La Fe, Valencia University, Valencia, Spain
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.6312.6 schema:alternateName University of Vigo
272 schema:name Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Universidade de Vigo, Vigo, Spain
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...