Ontology type: schema:ScholarlyArticle
2018-10
AUTHORSIrene Woo, Lane K. Christenson, Sumedha Gunewardena, Sue Ann Ingles, Semara Thomas, Ali Ahmady, Karine Chung, Kristin Bendikson, Richard Paulson, Lynda K. McGinnis
ABSTRACTPURPOSE: The study aims to determine differences in micro-RNA (miRNA) expression in granulosa (GC) and cumulus cells (CC) between young women with diminished ovarian reserve (DOR) or normal ovarian reserve (NOR). Secondary objective was to identify downstream signaling pathways that could ultimately indicate causes of lower developmental competence of oocytes from young women with DOR. METHODS: The method of the study is prospective cohort study. RESULTS: Of the miRNA, 125 are differentially expressed in GC between DOR and NOR. Only nine miRNA were different in CC; therefore, we focused analysis on GC. In DOR GC, miR-100-5p, miR-16-5p, miR-30a-3p, and miR-193a-3p were significantly downregulated, while miR-155-5p, miR-192-5p, miR-128-3p, miR-486-5p, miR130a-3p, miR-92a-3p, miR-17-3p, miR-221-3p, and miR-175p were increased. This pattern predicted higher cell proliferation in the DOR GC. The primary pathways include MAPK, Wnt, and TGFbeta. CONCLUSIONS: The miRNA pattern identified critical functions in cell proliferation and survival associated with DOR. GC in women with DOR seems to respond differently to the LH surge. More... »
PAGES1777-1786
http://scigraph.springernature.com/pub.10.1007/s10815-018-1239-9
DOIhttp://dx.doi.org/10.1007/s10815-018-1239-9
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29987422
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"description": "PURPOSE: The study aims to determine differences in micro-RNA (miRNA) expression in granulosa (GC) and cumulus cells (CC) between young women with diminished ovarian reserve (DOR) or normal ovarian reserve (NOR). Secondary objective was to identify downstream signaling pathways that could ultimately indicate causes of lower developmental competence of oocytes from young women with DOR.\nMETHODS: The method of the study is prospective cohort study.\nRESULTS: Of the miRNA, 125 are differentially expressed in GC between DOR and NOR. Only nine miRNA were different in CC; therefore, we focused analysis on GC. In DOR GC, miR-100-5p, miR-16-5p, miR-30a-3p, and miR-193a-3p were significantly downregulated, while miR-155-5p, miR-192-5p, miR-128-3p, miR-486-5p, miR130a-3p, miR-92a-3p, miR-17-3p, miR-221-3p, and miR-175p were increased. This pattern predicted higher cell proliferation in the DOR GC. The primary pathways include MAPK, Wnt, and TGFbeta.\nCONCLUSIONS: The miRNA pattern identified critical functions in cell proliferation and survival associated with DOR. GC in women with DOR seems to respond differently to the LH surge.",
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]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29987422"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9206495"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10815-018-1239-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
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]
}
],
"sameAs": [
"https://doi.org/10.1007/s10815-018-1239-9",
"https://app.dimensions.ai/details/publication/pub.1105427148"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78956_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10815-018-1239-9"
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]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10815-018-1239-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10815-018-1239-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10815-018-1239-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10815-018-1239-9'
This table displays all metadata directly associated to this object as RDF triples.
341 TRIPLES
21 PREDICATES
90 URIs
33 LITERALS
21 BLANK NODES