Genetic analysis of the M2/ANXA5 haplotype as recurrent pregnancy loss predisposition in the Malay population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04

AUTHORS

Kai-Cheen Ang, Sushilnathan Kathirgamanathan, Ewe Seng Ch’ng, Yan-Yeow Lee, Anna-Liza Roslani, Bavanandan Naidu, Krishna Kumar, Ridzuan Abdullah, Siti-Nadiah Abdul Kadir, Narazah Mohd Yusoff, Wan Zaidah Abdullah, Nadja Bogdanova, Peter Wieacker, Arseni Markoff, Thean-Hock Tang

ABSTRACT

PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out. METHODS: A total of 232 women who had experienced ≥2 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls. Prevalence of M2 carriage and RPL odds ratios were calculated in (a) control and patient groups; (b) clinically defined subgroups in categories of pregnancy loss, primary, secondary, and tertiary; and (c) timing of pregnancy loss in early, ≤15th gestation week and "late" fetal losses, and >15th gestation week subgroups. RESULTS: Both male and female subjects had similar M2/ANXA5 allele frequencies. The carrier rate of M2/ANXA5 for the general Malay population was 42.2 and 34.9% for parous controls. These carrier rates compared to Malay RPL subjects (52% M2 carriers) resulted in elevated odds ratios (95% confidence interval) of 1.53 (1.1 to 2.1) and 1.97 (1.3 to 3.1) accordingly for early fetal losses. Moreover, exceeding copy numbers of M2/ANXA5 alleles seemed to afflict a greater chance of RPL in couples, especially when both partners were M2 carriers. CONCLUSION: This study confirmed the proposed role of M2/ANXA5 as embryonic, genetically associated thrombophilia predisposition factor for early RPL among ethnic Malay of Malaysia. More... »

PAGES

517-524

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10815-017-0871-0

DOI

http://dx.doi.org/10.1007/s10815-017-0871-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053953550

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28108842


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Abortion, Habitual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Annexin A5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Advanced Medical and Dental Institute, University Sains Malaysia, Bertam, Penang, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ang", 
        "givenName": "Kai-Cheen", 
        "id": "sg:person.01074657750.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074657750.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sultan Abdul Halim Hospital", 
          "id": "https://www.grid.ac/institutes/grid.461061.4", 
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kathirgamanathan", 
        "givenName": "Sushilnathan", 
        "id": "sg:person.01132142206.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132142206.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Advanced Medical and Dental Institute, University Sains Malaysia, Bertam, Penang, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ch\u2019ng", 
        "givenName": "Ewe Seng", 
        "id": "sg:person.01165655606.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165655606.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Tuanku Jaafar, Seremban, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yan-Yeow", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Tengku Ampuan Afzan", 
          "id": "https://www.grid.ac/institutes/grid.413479.c", 
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Tengku Ampuan Afzan, Kuantan, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roslani", 
        "givenName": "Anna-Liza", 
        "id": "sg:person.013416404755.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013416404755.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Sultanah Bahiyah", 
          "id": "https://www.grid.ac/institutes/grid.452819.3", 
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Sultanah Bahiyah, Alor Setar, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naidu", 
        "givenName": "Bavanandan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Tuanku Jaafar, Seremban, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumar", 
        "givenName": "Krishna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sultan Abdul Halim Hospital", 
          "id": "https://www.grid.ac/institutes/grid.461061.4", 
          "name": [
            "Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdullah", 
        "givenName": "Ridzuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sultan Abdul Halim Hospital", 
          "id": "https://www.grid.ac/institutes/grid.461061.4", 
          "name": [
            "Department of Pathology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadir", 
        "givenName": "Siti-Nadiah Abdul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Advanced Medical and Dental Institute, University Sains Malaysia, Bertam, Penang, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yusoff", 
        "givenName": "Narazah Mohd", 
        "id": "sg:person.0737266553.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737266553.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdullah", 
        "givenName": "Wan Zaidah", 
        "id": "sg:person.0671322333.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671322333.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Institute of Human Genetics, University of Muenster, Muenster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanova", 
        "givenName": "Nadja", 
        "id": "sg:person.07754120104.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07754120104.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Institute of Human Genetics, University of Muenster, Muenster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wieacker", 
        "givenName": "Peter", 
        "id": "sg:person.01135705644.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135705644.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Institute of Human Genetics, University of Muenster, Muenster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Markoff", 
        "givenName": "Arseni", 
        "id": "sg:person.0702420217.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702420217.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Advanced Medical and Dental Institute, University Sains Malaysia, Bertam, Penang, Malaysia", 
            "Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Bertam, Kepala Batas, Penang, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Thean-Hock", 
        "id": "sg:person.01100271547.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100271547.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1471-8286.2007.01931.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001508219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6874-12-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001915896", 
          "https://doi.org/10.1186/1472-6874-12-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2010.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006366034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12687-010-0011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008093179", 
          "https://doi.org/10.1007/s12687-010-0011-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12687-010-0011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008093179", 
          "https://doi.org/10.1007/s12687-010-0011-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rbmo.2015.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013973969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rbmo.2015.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013973969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0004-8666.2002.00164.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014315811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-015-1620-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014704803", 
          "https://doi.org/10.1007/s00439-015-1620-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-015-1620-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014704803", 
          "https://doi.org/10.1007/s00439-015-1620-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-015-1620-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014704803", 
          "https://doi.org/10.1007/s00439-015-1620-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.14655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015767158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.14655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015767158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddm017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021692296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0131606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022255398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2013.06.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023005124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1076029616658117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1076029616658117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63479-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023966145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rbmo.2014.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026298431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010539511401374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027845394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010539511401374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027845394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6926(03)00017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031512513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6926(03)00017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031512513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1447-0756.2009.01067.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032457814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1447-0756.2009.01067.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032457814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2007.12.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037261007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humupd/8.5.463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038933322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gar008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039902907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041201522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0015-0282(99)00133-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045209860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2016.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046265921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6926(02)00099-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046284911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1521-6926(02)00099-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046284911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2003.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048479089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2012.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050524268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2008.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050584703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ebiom.2016.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053267826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-996025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057522238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7099.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7099.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th03-09-0596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063289988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th09-02-0123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063292004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075152245", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0037-1615049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083253782"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-04", 
    "datePublishedReg": "2017-04-01", 
    "description": "PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out.\nMETHODS: A total of 232 women who had experienced \u22652 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls. Prevalence of M2 carriage and RPL odds ratios were calculated in (a) control and patient groups; (b) clinically defined subgroups in categories of pregnancy loss, primary, secondary, and tertiary; and (c) timing of pregnancy loss in early, \u226415th gestation week and \"late\" fetal losses, and >15th gestation week subgroups.\nRESULTS: Both male and female subjects had similar M2/ANXA5 allele frequencies. The carrier rate of M2/ANXA5 for the general Malay population was 42.2 and 34.9% for parous controls. These carrier rates compared to Malay RPL subjects (52% M2 carriers) resulted in elevated odds ratios (95% confidence interval) of 1.53 (1.1 to 2.1) and 1.97 (1.3 to 3.1) accordingly for early fetal losses. Moreover, exceeding copy numbers of M2/ANXA5 alleles seemed to afflict a greater chance of RPL in couples, especially when both partners were M2 carriers.\nCONCLUSION: This study confirmed the proposed role of M2/ANXA5 as embryonic, genetically associated thrombophilia predisposition factor for early RPL among ethnic Malay of Malaysia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10815-017-0871-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1095018", 
        "issn": [
          "1058-0468", 
          "1573-7330"
        ], 
        "name": "Journal of Assisted Reproduction and Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Genetic analysis of the M2/ANXA5 haplotype as recurrent pregnancy loss predisposition in the Malay population", 
    "pagination": "517-524", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9a2590059f4da8e5fea5d5ed4a692488b969bd81155d51cd7d2a9203e609750a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28108842"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9206495"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10815-017-0871-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053953550"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10815-017-0871-0", 
      "https://app.dimensions.ai/details/publication/pub.1053953550"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113679_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10815-017-0871-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10815-017-0871-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10815-017-0871-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10815-017-0871-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10815-017-0871-0'


 

This table displays all metadata directly associated to this object as RDF triples.

345 TRIPLES      21 PREDICATES      78 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10815-017-0871-0 schema:about N0ad06e28719345379ead78a4e1cf9117
2 N0ee4bd97369548f5a7f651183eeb96ea
3 N1768967b6a17468892b92f0f4d559ec4
4 N20648279b0324ca88fabfde4ee42ccde
5 N22ce4546e9b6497986671918af945851
6 N4415bfe4427048b4a12f8d5575014b25
7 N45e04fe9e7bc42bfb60ed8761e0f4a7f
8 N5554a80f2fb34fe9bafc9298b5d1e2c9
9 N6431deb52f1e4ae7bde467e34be32de6
10 N765759918e6449d1aea514e127fa8d85
11 N86701aa7250742138043910af8056363
12 N915a0f48173945679ddeb8897b709eb6
13 N9f4143d8220b46de93c8fd32b617e7fa
14 Nf1ed2bf9837f47da841ef8be4501757e
15 Nf40ce089e0ae4a9f95d15e8a4ec3fc18
16 anzsrc-for:11
17 anzsrc-for:1114
18 schema:author N7f62e11d7630421ba5fef340fb8f7dd5
19 schema:citation sg:pub.10.1007/s00439-015-1620-z
20 sg:pub.10.1007/s12687-010-0011-3
21 sg:pub.10.1186/1472-6874-12-15
22 https://app.dimensions.ai/details/publication/pub.1075152245
23 https://doi.org/10.1002/uog.14655
24 https://doi.org/10.1016/j.ebiom.2016.06.024
25 https://doi.org/10.1016/j.fertnstert.2003.10.004
26 https://doi.org/10.1016/j.fertnstert.2007.12.056
27 https://doi.org/10.1016/j.fertnstert.2008.03.002
28 https://doi.org/10.1016/j.fertnstert.2012.04.026
29 https://doi.org/10.1016/j.fertnstert.2013.06.046
30 https://doi.org/10.1016/j.placenta.2010.08.002
31 https://doi.org/10.1016/j.placenta.2013.09.010
32 https://doi.org/10.1016/j.rbmo.2014.12.014
33 https://doi.org/10.1016/j.rbmo.2015.07.004
34 https://doi.org/10.1016/j.thromres.2016.06.009
35 https://doi.org/10.1016/s0002-9440(10)63479-7
36 https://doi.org/10.1016/s0015-0282(99)00133-8
37 https://doi.org/10.1016/s1521-6926(02)00099-3
38 https://doi.org/10.1016/s1521-6926(03)00017-3
39 https://doi.org/10.1055/s-0037-1615049
40 https://doi.org/10.1055/s-2007-996025
41 https://doi.org/10.1093/hmg/ddm017
42 https://doi.org/10.1093/humupd/8.5.463
43 https://doi.org/10.1093/molehr/gar008
44 https://doi.org/10.1111/j.0004-8666.2002.00164.x
45 https://doi.org/10.1111/j.1447-0756.2009.01067.x
46 https://doi.org/10.1111/j.1471-8286.2007.01931.x
47 https://doi.org/10.1136/bmj.315.7099.32
48 https://doi.org/10.1160/th03-09-0596
49 https://doi.org/10.1160/th09-02-0123
50 https://doi.org/10.1177/1010539511401374
51 https://doi.org/10.1177/1076029616658117
52 https://doi.org/10.1371/journal.pone.0131606
53 schema:datePublished 2017-04
54 schema:datePublishedReg 2017-04-01
55 schema:description PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out. METHODS: A total of 232 women who had experienced ≥2 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls. Prevalence of M2 carriage and RPL odds ratios were calculated in (a) control and patient groups; (b) clinically defined subgroups in categories of pregnancy loss, primary, secondary, and tertiary; and (c) timing of pregnancy loss in early, ≤15th gestation week and "late" fetal losses, and >15th gestation week subgroups. RESULTS: Both male and female subjects had similar M2/ANXA5 allele frequencies. The carrier rate of M2/ANXA5 for the general Malay population was 42.2 and 34.9% for parous controls. These carrier rates compared to Malay RPL subjects (52% M2 carriers) resulted in elevated odds ratios (95% confidence interval) of 1.53 (1.1 to 2.1) and 1.97 (1.3 to 3.1) accordingly for early fetal losses. Moreover, exceeding copy numbers of M2/ANXA5 alleles seemed to afflict a greater chance of RPL in couples, especially when both partners were M2 carriers. CONCLUSION: This study confirmed the proposed role of M2/ANXA5 as embryonic, genetically associated thrombophilia predisposition factor for early RPL among ethnic Malay of Malaysia.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N59a7c47641164e069b7e4f59e530c31a
60 Ne3682208742e43f387a20ef9e31ec2d6
61 sg:journal.1095018
62 schema:name Genetic analysis of the M2/ANXA5 haplotype as recurrent pregnancy loss predisposition in the Malay population
63 schema:pagination 517-524
64 schema:productId N38600c341d6b45439078d21399d3b1bb
65 N3f88bcefc504424c88fdd55e39581352
66 Ndb58ce1c10a54886975d88dd8061bd3f
67 Ne1300e9e89764986b720c18c34ef4f00
68 Nf85966cbd36f46e6b4ed5508d2162a22
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053953550
70 https://doi.org/10.1007/s10815-017-0871-0
71 schema:sdDatePublished 2019-04-11T10:39
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N238fce0c8191413c932e2c8328d31c92
74 schema:url https://link.springer.com/10.1007%2Fs10815-017-0871-0
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0ad06e28719345379ead78a4e1cf9117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Genetic Testing
80 rdf:type schema:DefinedTerm
81 N0ee4bd97369548f5a7f651183eeb96ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Female
83 rdf:type schema:DefinedTerm
84 N1768967b6a17468892b92f0f4d559ec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Genetic Predisposition to Disease
86 rdf:type schema:DefinedTerm
87 N1de8c1404eec42c89dd1b097dadbc092 rdf:first N953415b027e745a3b0a9ca63cd68c6f8
88 rdf:rest Nc09c8f8e57824175a4f7d5f95467a70b
89 N20648279b0324ca88fabfde4ee42ccde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Abortion, Habitual
91 rdf:type schema:DefinedTerm
92 N22ce4546e9b6497986671918af945851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Pregnancy
94 rdf:type schema:DefinedTerm
95 N238fce0c8191413c932e2c8328d31c92 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N38600c341d6b45439078d21399d3b1bb schema:name doi
98 schema:value 10.1007/s10815-017-0871-0
99 rdf:type schema:PropertyValue
100 N3a2d0150cbc54980b0548487889498c1 rdf:first sg:person.01132142206.02
101 rdf:rest Nefa9056f852d4dd091f56df484741c5a
102 N3c6f81fddae64f80910415ab85dd4cf0 rdf:first sg:person.0737266553.26
103 rdf:rest Nf5a6af98080e4a2b84843f2b6e22ec6d
104 N3f88bcefc504424c88fdd55e39581352 schema:name nlm_unique_id
105 schema:value 9206495
106 rdf:type schema:PropertyValue
107 N4415bfe4427048b4a12f8d5575014b25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Male
109 rdf:type schema:DefinedTerm
110 N45e04fe9e7bc42bfb60ed8761e0f4a7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Young Adult
112 rdf:type schema:DefinedTerm
113 N477595c98e5643629524476f26acf605 rdf:first sg:person.07754120104.39
114 rdf:rest Nb43d734af7d94f3eab1e83d5f1b7e453
115 N50625badac9d476982ab6808a28dd7e9 rdf:first Na3cc233c78dc41b78105baf63385b234
116 rdf:rest N1de8c1404eec42c89dd1b097dadbc092
117 N5554a80f2fb34fe9bafc9298b5d1e2c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Heterozygote
119 rdf:type schema:DefinedTerm
120 N59a7c47641164e069b7e4f59e530c31a schema:volumeNumber 34
121 rdf:type schema:PublicationVolume
122 N62ff607c97e94ff69c0305cddd35be75 rdf:first sg:person.01100271547.89
123 rdf:rest rdf:nil
124 N6431deb52f1e4ae7bde467e34be32de6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Gene Frequency
126 rdf:type schema:DefinedTerm
127 N647dda3e3f97456f85811cfe80d59f3f rdf:first Nc796f586dca4461eab96dbf537df7ffd
128 rdf:rest N3c6f81fddae64f80910415ab85dd4cf0
129 N6e8590945bcd4fa99a82135f2d515bea schema:name Department of Obstetrics and Gynaecology, Hospital Tuanku Jaafar, Seremban, Malaysia
130 rdf:type schema:Organization
131 N765759918e6449d1aea514e127fa8d85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adult
133 rdf:type schema:DefinedTerm
134 N7bd323b978c94c4db2e571df25f15205 rdf:first Nb9f3dc08a211424b91d2e66cbfc4838e
135 rdf:rest Ndfd1f1c8bc974d2e9df86dfbdd277ab6
136 N7f62e11d7630421ba5fef340fb8f7dd5 rdf:first sg:person.01074657750.47
137 rdf:rest N3a2d0150cbc54980b0548487889498c1
138 N86701aa7250742138043910af8056363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Haplotypes
140 rdf:type schema:DefinedTerm
141 N915a0f48173945679ddeb8897b709eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Risk Factors
143 rdf:type schema:DefinedTerm
144 N953415b027e745a3b0a9ca63cd68c6f8 schema:affiliation Nffeb8446d4e0492f9fd9518172e8da97
145 schema:familyName Kumar
146 schema:givenName Krishna
147 rdf:type schema:Person
148 N9f4143d8220b46de93c8fd32b617e7fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Genotype
150 rdf:type schema:DefinedTerm
151 Na3cc233c78dc41b78105baf63385b234 schema:affiliation https://www.grid.ac/institutes/grid.452819.3
152 schema:familyName Naidu
153 schema:givenName Bavanandan
154 rdf:type schema:Person
155 Naea999b36c2e4215872eb483788c9ca8 schema:affiliation https://www.grid.ac/institutes/grid.461061.4
156 schema:familyName Abdullah
157 schema:givenName Ridzuan
158 rdf:type schema:Person
159 Nb43d734af7d94f3eab1e83d5f1b7e453 rdf:first sg:person.01135705644.39
160 rdf:rest Nb5be4ddea074458e8004458a7d2dea74
161 Nb5be4ddea074458e8004458a7d2dea74 rdf:first sg:person.0702420217.12
162 rdf:rest N62ff607c97e94ff69c0305cddd35be75
163 Nb9f3dc08a211424b91d2e66cbfc4838e schema:affiliation N6e8590945bcd4fa99a82135f2d515bea
164 schema:familyName Lee
165 schema:givenName Yan-Yeow
166 rdf:type schema:Person
167 Nc09c8f8e57824175a4f7d5f95467a70b rdf:first Naea999b36c2e4215872eb483788c9ca8
168 rdf:rest N647dda3e3f97456f85811cfe80d59f3f
169 Nc796f586dca4461eab96dbf537df7ffd schema:affiliation https://www.grid.ac/institutes/grid.461061.4
170 schema:familyName Kadir
171 schema:givenName Siti-Nadiah Abdul
172 rdf:type schema:Person
173 Ndb58ce1c10a54886975d88dd8061bd3f schema:name dimensions_id
174 schema:value pub.1053953550
175 rdf:type schema:PropertyValue
176 Ndfd1f1c8bc974d2e9df86dfbdd277ab6 rdf:first sg:person.013416404755.62
177 rdf:rest N50625badac9d476982ab6808a28dd7e9
178 Ne1300e9e89764986b720c18c34ef4f00 schema:name pubmed_id
179 schema:value 28108842
180 rdf:type schema:PropertyValue
181 Ne3682208742e43f387a20ef9e31ec2d6 schema:issueNumber 4
182 rdf:type schema:PublicationIssue
183 Nefa9056f852d4dd091f56df484741c5a rdf:first sg:person.01165655606.65
184 rdf:rest N7bd323b978c94c4db2e571df25f15205
185 Nf1ed2bf9837f47da841ef8be4501757e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Annexin A5
187 rdf:type schema:DefinedTerm
188 Nf40ce089e0ae4a9f95d15e8a4ec3fc18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Humans
190 rdf:type schema:DefinedTerm
191 Nf5a6af98080e4a2b84843f2b6e22ec6d rdf:first sg:person.0671322333.46
192 rdf:rest N477595c98e5643629524476f26acf605
193 Nf85966cbd36f46e6b4ed5508d2162a22 schema:name readcube_id
194 schema:value 9a2590059f4da8e5fea5d5ed4a692488b969bd81155d51cd7d2a9203e609750a
195 rdf:type schema:PropertyValue
196 Nffeb8446d4e0492f9fd9518172e8da97 schema:name Department of Obstetrics and Gynaecology, Hospital Tuanku Jaafar, Seremban, Malaysia
197 rdf:type schema:Organization
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
202 schema:name Paediatrics and Reproductive Medicine
203 rdf:type schema:DefinedTerm
204 sg:journal.1095018 schema:issn 1058-0468
205 1573-7330
206 schema:name Journal of Assisted Reproduction and Genetics
207 rdf:type schema:Periodical
208 sg:person.01074657750.47 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
209 schema:familyName Ang
210 schema:givenName Kai-Cheen
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074657750.47
212 rdf:type schema:Person
213 sg:person.01100271547.89 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
214 schema:familyName Tang
215 schema:givenName Thean-Hock
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100271547.89
217 rdf:type schema:Person
218 sg:person.01132142206.02 schema:affiliation https://www.grid.ac/institutes/grid.461061.4
219 schema:familyName Kathirgamanathan
220 schema:givenName Sushilnathan
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132142206.02
222 rdf:type schema:Person
223 sg:person.01135705644.39 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
224 schema:familyName Wieacker
225 schema:givenName Peter
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135705644.39
227 rdf:type schema:Person
228 sg:person.01165655606.65 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
229 schema:familyName Ch’ng
230 schema:givenName Ewe Seng
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165655606.65
232 rdf:type schema:Person
233 sg:person.013416404755.62 schema:affiliation https://www.grid.ac/institutes/grid.413479.c
234 schema:familyName Roslani
235 schema:givenName Anna-Liza
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013416404755.62
237 rdf:type schema:Person
238 sg:person.0671322333.46 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
239 schema:familyName Abdullah
240 schema:givenName Wan Zaidah
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671322333.46
242 rdf:type schema:Person
243 sg:person.0702420217.12 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
244 schema:familyName Markoff
245 schema:givenName Arseni
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702420217.12
247 rdf:type schema:Person
248 sg:person.0737266553.26 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
249 schema:familyName Yusoff
250 schema:givenName Narazah Mohd
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737266553.26
252 rdf:type schema:Person
253 sg:person.07754120104.39 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
254 schema:familyName Bogdanova
255 schema:givenName Nadja
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07754120104.39
257 rdf:type schema:Person
258 sg:pub.10.1007/s00439-015-1620-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014704803
259 https://doi.org/10.1007/s00439-015-1620-z
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/s12687-010-0011-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008093179
262 https://doi.org/10.1007/s12687-010-0011-3
263 rdf:type schema:CreativeWork
264 sg:pub.10.1186/1472-6874-12-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001915896
265 https://doi.org/10.1186/1472-6874-12-15
266 rdf:type schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1075152245 schema:CreativeWork
268 https://doi.org/10.1002/uog.14655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015767158
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.ebiom.2016.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053267826
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.fertnstert.2003.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048479089
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.fertnstert.2007.12.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037261007
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.fertnstert.2008.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050584703
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.fertnstert.2012.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050524268
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.fertnstert.2013.06.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023005124
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.placenta.2010.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006366034
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.placenta.2013.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041201522
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.rbmo.2014.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026298431
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.rbmo.2015.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013973969
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.thromres.2016.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046265921
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0002-9440(10)63479-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023966145
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0015-0282(99)00133-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045209860
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s1521-6926(02)00099-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046284911
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s1521-6926(03)00017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031512513
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1055/s-0037-1615049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083253782
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1055/s-2007-996025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057522238
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/hmg/ddm017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021692296
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/humupd/8.5.463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038933322
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/molehr/gar008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039902907
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.0004-8666.2002.00164.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014315811
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1447-0756.2009.01067.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032457814
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1471-8286.2007.01931.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001508219
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1136/bmj.315.7099.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062780109
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1160/th03-09-0596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063289988
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1160/th09-02-0123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063292004
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1177/1010539511401374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027845394
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1177/1076029616658117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023542061
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1371/journal.pone.0131606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022255398
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.11875.3a schema:alternateName Universiti Sains Malaysia
329 schema:name Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Bertam, Kepala Batas, Penang, Malaysia
330 Advanced Medical and Dental Institute, University Sains Malaysia, Bertam, Penang, Malaysia
331 Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.413479.c schema:alternateName Hospital Tengku Ampuan Afzan
334 schema:name Department of Obstetrics and Gynaecology, Hospital Tengku Ampuan Afzan, Kuantan, Malaysia
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.452819.3 schema:alternateName Hospital Sultanah Bahiyah
337 schema:name Department of Obstetrics and Gynaecology, Hospital Sultanah Bahiyah, Alor Setar, Malaysia
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.461061.4 schema:alternateName Sultan Abdul Halim Hospital
340 schema:name Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia
341 Department of Pathology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.5949.1 schema:alternateName University of Münster
344 schema:name Institute of Human Genetics, University of Muenster, Muenster, Germany
345 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...