Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

M. M. Dolmans, S. Hollanders de Ouderaen, D. Demylle, C. Pirard

ABSTRACT

PURPOSE: The aim of this study was to evaluate long-term embryo cryopreservation, utilization, and success rate in patients subjected to gonadotoxic treatments in the context of cancer. METHODS: This is a retrospective study on patients (n = 54) undergoing ovarian stimulation and IVF for fertility preservation between January 1997 and June 2014. Embryos were slow-frozen and stored until the women were cured and able to undergo embryo transfer. RESULTS: Fifty-four women underwent 66 oocyte pick-up procedures in total, and embryos were obtained from 52 of the 54 patients. Four patients died before their frozen embryos could be thawed. Of the remaining 48, 9 women returned to use their embryos, resulting in 6 pregnancies (66% cumulative pregnancy rate), two of which ended in miscarriage. The live birth rate per patient was thus 44% (4/9). The true come-back rate, calculated after applicable exclusions, was found to be 23%. CONCLUSION: IVF followed by embryo freezing is a widely established technique for fertility preservation, but little has been published on the outcomes in cancer patients. While we found the number of good-quality embryos to be lower than in a normal population, the cumulative live birth rate was similar to that achieved with fresh embryos in non-cancer patients. The utilization rate of this fertility preservation method can be considered high. More... »

PAGES

1233-1237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10815-015-0533-z

DOI

http://dx.doi.org/10.1007/s10815-015-0533-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008985719

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26174124


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