High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06-01

AUTHORS

Mausumi Das, Naif Al-Hathal, Maria San-Gabriel, Simon Phillips, Isaac-Jacques Kadoch, Francois Bissonnette, Hananel Holzer, Armand Zini

ABSTRACT

BackgroundSperm DNA damage is associated with male infertility, lower pregnancy rates and pregnancy loss.ObjectiveThe primary aim of our study was to evaluate the prevalence of sperm DNA damage in younger and older men with normozoospermia.Design, Setting and ParticipantsWe obtained semen from 277 consecutive non-azoospermic men presenting for sperm DNA testing.Outcome Measurements and Statistical AnalysisThe main outcome measures included sperm % DNA fragmentation index (%DFI, using sperm chromatin structure assay), sperm concentration, motility and morphology, and, paternal age.Results and LimitationsSperm % DFI was positively correlated with paternal age (r = 0.20, P < 0.001) and inversely correlated % progressive motility (r = −0.16, P = 0.01). Sperm %DFI was significantly higher in older (≥40 years) compared to younger (<40 years) normozoospermic men (17 ± 13 vs. 12 ± 8, respectively P = 0.008), whereas, sperm concentration, progressive motility and morphology were not significantly different in these two groups. Moreover, the prevalence of high levels of sperm DNA damage (>30 % DFI) was significantly higher in older compared to younger normozoospermic men (17 % vs. 3 %, respectively, P < 0.001).ConclusionThe data indicate that a conventional semen analysis can often fail to detect a defect in spermatogenesis (high %DFI) in older men and suggest that infertile couples with advanced paternal age, including those with normal semen parameters, should consider sperm DNA testing as part of the couple evaluation. More... »

PAGES

843-848

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10815-013-0015-0

DOI

http://dx.doi.org/10.1007/s10815-013-0015-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034300578

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23722935


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Fragmentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infertility, Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paternal Age", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ploidies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Semen Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sperm Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermatogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermatozoa", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Das", 
        "givenName": "Mausumi", 
        "id": "sg:person.01031444525.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031444525.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Hathal", 
        "givenName": "Naif", 
        "id": "sg:person.01012030211.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012030211.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "San-Gabriel", 
        "givenName": "Maria", 
        "id": "sg:person.01242440026.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242440026.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "OVO Fertility Clinic, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "OVO Fertility Clinic, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phillips", 
        "givenName": "Simon", 
        "id": "sg:person.01251574254.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251574254.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier de l\u2019Universite de Montreal, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.410559.c", 
          "name": [
            "OVO Fertility Clinic, Montreal, Quebec, Canada", 
            "Centre Hospitalier de l\u2019Universite de Montreal, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadoch", 
        "givenName": "Isaac-Jacques", 
        "id": "sg:person.0641545226.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641545226.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier de l\u2019Universite de Montreal, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.410559.c", 
          "name": [
            "OVO Fertility Clinic, Montreal, Quebec, Canada", 
            "Centre Hospitalier de l\u2019Universite de Montreal, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bissonnette", 
        "givenName": "Francois", 
        "id": "sg:person.0661436421.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661436421.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holzer", 
        "givenName": "Hananel", 
        "id": "sg:person.0605514460.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605514460.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Mary\u2019s Hospital, 3830 Lacombe Ave., H3T 1M5, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.416526.2", 
          "name": [
            "Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada", 
            "St. Mary\u2019s Hospital, 3830 Lacombe Ave., H3T 1M5, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zini", 
        "givenName": "Armand", 
        "id": "sg:person.0602500535.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602500535.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf03340164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014466678", 
          "https://doi.org/10.1007/bf03340164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4899-0089-0_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027670463", 
          "https://doi.org/10.1007/978-1-4899-0089-0_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029300076", 
          "https://doi.org/10.1038/nature11396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10815-011-9544-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020995454", 
          "https://doi.org/10.1007/s10815-011-9544-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06-01", 
    "datePublishedReg": "2013-06-01", 
    "description": "BackgroundSperm DNA damage is associated with male infertility, lower pregnancy rates and pregnancy loss.ObjectiveThe primary aim of our study was to evaluate the prevalence of sperm DNA damage in younger and older men with normozoospermia.Design, Setting and ParticipantsWe obtained semen from 277 consecutive non-azoospermic men presenting for sperm DNA testing.Outcome Measurements and Statistical AnalysisThe main outcome measures included sperm % DNA fragmentation index (%DFI, using sperm chromatin structure assay), sperm concentration, motility and morphology, and, paternal age.Results and LimitationsSperm % DFI was positively correlated with paternal age (r\u2009=\u20090.20, P\u2009<\u20090.001) and inversely correlated % progressive motility (r\u2009=\u2009\u22120.16, P\u2009=\u20090.01). Sperm %DFI was significantly higher in older (\u226540\u00a0years) compared to younger (<40\u00a0years) normozoospermic men (17\u2009\u00b1\u200913 vs. 12\u2009\u00b1\u20098, respectively P\u2009=\u20090.008), whereas, sperm concentration, progressive motility and morphology were not significantly different in these two groups. Moreover, the prevalence of high levels of sperm DNA damage (>30\u00a0% DFI) was significantly higher in older compared to younger normozoospermic men (17\u00a0% vs. 3\u00a0%, respectively, P\u2009<\u20090.001).ConclusionThe data indicate that a conventional semen analysis can often fail to detect a defect in spermatogenesis (high %DFI) in older men and suggest that infertile couples with advanced paternal age, including those with normal semen parameters, should consider sperm DNA testing as part of the couple evaluation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10815-013-0015-0", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1095018", 
        "issn": [
          "1058-0468", 
          "1573-7330"
        ], 
        "name": "Journal of Assisted Reproduction and Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "sperm DNA testing", 
      "sperm DNA damage", 
      "advanced paternal age", 
      "paternal age", 
      "older men", 
      "normozoospermic men", 
      "main outcome measures", 
      "DNA testing", 
      "sperm concentration", 
      "lower pregnancy rates", 
      "normal semen parameters", 
      "non-azoospermic men", 
      "DNA damage", 
      "conventional semen analysis", 
      "progressive motility", 
      "pregnancy loss", 
      "DNA fragmentation index", 
      "pregnancy rate", 
      "high prevalence", 
      "outcome measures", 
      "infertile couples", 
      "infertile men", 
      "male infertility", 
      "outcome measurements", 
      "semen parameters", 
      "semen analysis", 
      "prevalence", 
      "men", 
      "age", 
      "primary aim", 
      "couple evaluation", 
      "motility", 
      "fragmentation index", 
      "damage", 
      "high levels", 
      "ParticipantsWe", 
      "infertility", 
      "DFI", 
      "normozoospermia", 
      "sperm", 
      "testing", 
      "spermatogenesis", 
      "group", 
      "aim", 
      "semen", 
      "concentration", 
      "setting", 
      "index", 
      "levels", 
      "evaluation", 
      "study", 
      "measures", 
      "rate", 
      "defects", 
      "loss", 
      "data", 
      "couples", 
      "analysis", 
      "results", 
      "morphology", 
      "part", 
      "measurements", 
      "parameters", 
      "design"
    ], 
    "name": "High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age", 
    "pagination": "843-848", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034300578"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10815-013-0015-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23722935"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10815-013-0015-0", 
      "https://app.dimensions.ai/details/publication/pub.1034300578"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_588.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10815-013-0015-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10815-013-0015-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10815-013-0015-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10815-013-0015-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10815-013-0015-0'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      109 URIs      96 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10815-013-0015-0 schema:about N061b8166f12c453da6da0582b3414627
2 N1916e59a660f4a3f9e67c7851ecfd4b9
3 N309f14e4ac4f45ce8ba60c4f4fb9a14b
4 N6b260bef3dd440b6865921b0e2657a02
5 N6ca2e92fc60940969f344b36c8ab045d
6 N77fd5a2a727c4d149958d552075de74d
7 N79347acf236247d6be90c76b06ef6bb0
8 N7cceeea68fa3485db756853328dfc514
9 Na5c2de13c44d4205b08209546dde2a1d
10 Nb0bfa166a40341889870aab9bfb90e9c
11 Nc02c8d086864440c80af030350ed3af6
12 Nc1b68d129218402388c5aac3577797e8
13 Ndbe5d40ee57a40a4a01832af8ca5ae9a
14 Nec6f63cdf43c4108bfddcae8f81ad2eb
15 Nf142498ae4dd4a4c9593df4e2b7c38fb
16 anzsrc-for:11
17 anzsrc-for:1103
18 anzsrc-for:1114
19 schema:author N742f3b5bcd8c4802a503a3965db15770
20 schema:citation sg:pub.10.1007/978-1-4899-0089-0_10
21 sg:pub.10.1007/bf03340164
22 sg:pub.10.1007/s10815-011-9544-6
23 sg:pub.10.1038/nature11396
24 schema:datePublished 2013-06-01
25 schema:datePublishedReg 2013-06-01
26 schema:description BackgroundSperm DNA damage is associated with male infertility, lower pregnancy rates and pregnancy loss.ObjectiveThe primary aim of our study was to evaluate the prevalence of sperm DNA damage in younger and older men with normozoospermia.Design, Setting and ParticipantsWe obtained semen from 277 consecutive non-azoospermic men presenting for sperm DNA testing.Outcome Measurements and Statistical AnalysisThe main outcome measures included sperm % DNA fragmentation index (%DFI, using sperm chromatin structure assay), sperm concentration, motility and morphology, and, paternal age.Results and LimitationsSperm % DFI was positively correlated with paternal age (r = 0.20, P < 0.001) and inversely correlated % progressive motility (r = −0.16, P = 0.01). Sperm %DFI was significantly higher in older (≥40 years) compared to younger (<40 years) normozoospermic men (17 ± 13 vs. 12 ± 8, respectively P = 0.008), whereas, sperm concentration, progressive motility and morphology were not significantly different in these two groups. Moreover, the prevalence of high levels of sperm DNA damage (>30 % DFI) was significantly higher in older compared to younger normozoospermic men (17 % vs. 3 %, respectively, P < 0.001).ConclusionThe data indicate that a conventional semen analysis can often fail to detect a defect in spermatogenesis (high %DFI) in older men and suggest that infertile couples with advanced paternal age, including those with normal semen parameters, should consider sperm DNA testing as part of the couple evaluation.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N098f094ce1b344c89f1c776d39d41008
30 N5e40f483f74e490d80956b34fc0777ac
31 sg:journal.1095018
32 schema:keywords DFI
33 DNA damage
34 DNA fragmentation index
35 DNA testing
36 ParticipantsWe
37 advanced paternal age
38 age
39 aim
40 analysis
41 concentration
42 conventional semen analysis
43 couple evaluation
44 couples
45 damage
46 data
47 defects
48 design
49 evaluation
50 fragmentation index
51 group
52 high levels
53 high prevalence
54 index
55 infertile couples
56 infertile men
57 infertility
58 levels
59 loss
60 lower pregnancy rates
61 main outcome measures
62 male infertility
63 measurements
64 measures
65 men
66 morphology
67 motility
68 non-azoospermic men
69 normal semen parameters
70 normozoospermia
71 normozoospermic men
72 older men
73 outcome measurements
74 outcome measures
75 parameters
76 part
77 paternal age
78 pregnancy loss
79 pregnancy rate
80 prevalence
81 primary aim
82 progressive motility
83 rate
84 results
85 semen
86 semen analysis
87 semen parameters
88 setting
89 sperm
90 sperm DNA damage
91 sperm DNA testing
92 sperm concentration
93 spermatogenesis
94 study
95 testing
96 schema:name High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age
97 schema:pagination 843-848
98 schema:productId N254f7265887947ec97e25d1d52db4ab7
99 N292ada8586674bd7b5432eded6ade215
100 Nc0b16102eebe419ba4b9fd2eaccc27ae
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034300578
102 https://doi.org/10.1007/s10815-013-0015-0
103 schema:sdDatePublished 2022-12-01T06:30
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N7eaeec6b9c1140d196d17570cd7a0ffb
106 schema:url https://doi.org/10.1007/s10815-013-0015-0
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N061b8166f12c453da6da0582b3414627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Spermatozoa
112 rdf:type schema:DefinedTerm
113 N098f094ce1b344c89f1c776d39d41008 schema:volumeNumber 30
114 rdf:type schema:PublicationVolume
115 N1916e59a660f4a3f9e67c7851ecfd4b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Spermatogenesis
117 rdf:type schema:DefinedTerm
118 N254f7265887947ec97e25d1d52db4ab7 schema:name doi
119 schema:value 10.1007/s10815-013-0015-0
120 rdf:type schema:PropertyValue
121 N292ada8586674bd7b5432eded6ade215 schema:name pubmed_id
122 schema:value 23722935
123 rdf:type schema:PropertyValue
124 N309f14e4ac4f45ce8ba60c4f4fb9a14b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Semen Analysis
126 rdf:type schema:DefinedTerm
127 N40b10c02358c49f5954c6b21030e8c6d rdf:first sg:person.0661436421.33
128 rdf:rest Nb1bc5e2c0aa24eeba5c8130079673e2f
129 N5e40f483f74e490d80956b34fc0777ac schema:issueNumber 6
130 rdf:type schema:PublicationIssue
131 N6b1a83ee4c4646f3a891ed2ebb079383 rdf:first sg:person.01242440026.69
132 rdf:rest N89c8d860c93d456483b7b867315d2e35
133 N6b260bef3dd440b6865921b0e2657a02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Sperm Count
135 rdf:type schema:DefinedTerm
136 N6ca2e92fc60940969f344b36c8ab045d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Paternal Age
138 rdf:type schema:DefinedTerm
139 N7235868a534f474ab6ab69816aca01eb rdf:first sg:person.01012030211.76
140 rdf:rest N6b1a83ee4c4646f3a891ed2ebb079383
141 N742f3b5bcd8c4802a503a3965db15770 rdf:first sg:person.01031444525.66
142 rdf:rest N7235868a534f474ab6ab69816aca01eb
143 N77fd5a2a727c4d149958d552075de74d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Infertility, Male
145 rdf:type schema:DefinedTerm
146 N79347acf236247d6be90c76b06ef6bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Pregnancy
148 rdf:type schema:DefinedTerm
149 N7cceeea68fa3485db756853328dfc514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name DNA Damage
151 rdf:type schema:DefinedTerm
152 N7eaeec6b9c1140d196d17570cd7a0ffb schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N81cfc7100dc04995881c945b9be46a8f rdf:first sg:person.0602500535.82
155 rdf:rest rdf:nil
156 N89c8d860c93d456483b7b867315d2e35 rdf:first sg:person.01251574254.78
157 rdf:rest Nb678a8d5be6644fbb6435bee5476fefa
158 Na5c2de13c44d4205b08209546dde2a1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 Nb0bfa166a40341889870aab9bfb90e9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name DNA Fragmentation
163 rdf:type schema:DefinedTerm
164 Nb1bc5e2c0aa24eeba5c8130079673e2f rdf:first sg:person.0605514460.26
165 rdf:rest N81cfc7100dc04995881c945b9be46a8f
166 Nb678a8d5be6644fbb6435bee5476fefa rdf:first sg:person.0641545226.82
167 rdf:rest N40b10c02358c49f5954c6b21030e8c6d
168 Nc02c8d086864440c80af030350ed3af6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Female
170 rdf:type schema:DefinedTerm
171 Nc0b16102eebe419ba4b9fd2eaccc27ae schema:name dimensions_id
172 schema:value pub.1034300578
173 rdf:type schema:PropertyValue
174 Nc1b68d129218402388c5aac3577797e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Middle Aged
176 rdf:type schema:DefinedTerm
177 Ndbe5d40ee57a40a4a01832af8ca5ae9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Humans
179 rdf:type schema:DefinedTerm
180 Nec6f63cdf43c4108bfddcae8f81ad2eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Adult
182 rdf:type schema:DefinedTerm
183 Nf142498ae4dd4a4c9593df4e2b7c38fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Ploidies
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
193 schema:name Paediatrics and Reproductive Medicine
194 rdf:type schema:DefinedTerm
195 sg:journal.1095018 schema:issn 1058-0468
196 1573-7330
197 schema:name Journal of Assisted Reproduction and Genetics
198 schema:publisher Springer Nature
199 rdf:type schema:Periodical
200 sg:person.01012030211.76 schema:affiliation grid-institutes:grid.14709.3b
201 schema:familyName Al-Hathal
202 schema:givenName Naif
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012030211.76
204 rdf:type schema:Person
205 sg:person.01031444525.66 schema:affiliation grid-institutes:grid.14709.3b
206 schema:familyName Das
207 schema:givenName Mausumi
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031444525.66
209 rdf:type schema:Person
210 sg:person.01242440026.69 schema:affiliation grid-institutes:grid.14709.3b
211 schema:familyName San-Gabriel
212 schema:givenName Maria
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242440026.69
214 rdf:type schema:Person
215 sg:person.01251574254.78 schema:affiliation grid-institutes:None
216 schema:familyName Phillips
217 schema:givenName Simon
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251574254.78
219 rdf:type schema:Person
220 sg:person.0602500535.82 schema:affiliation grid-institutes:grid.416526.2
221 schema:familyName Zini
222 schema:givenName Armand
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602500535.82
224 rdf:type schema:Person
225 sg:person.0605514460.26 schema:affiliation grid-institutes:grid.14709.3b
226 schema:familyName Holzer
227 schema:givenName Hananel
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605514460.26
229 rdf:type schema:Person
230 sg:person.0641545226.82 schema:affiliation grid-institutes:grid.410559.c
231 schema:familyName Kadoch
232 schema:givenName Isaac-Jacques
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641545226.82
234 rdf:type schema:Person
235 sg:person.0661436421.33 schema:affiliation grid-institutes:grid.410559.c
236 schema:familyName Bissonnette
237 schema:givenName Francois
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661436421.33
239 rdf:type schema:Person
240 sg:pub.10.1007/978-1-4899-0089-0_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027670463
241 https://doi.org/10.1007/978-1-4899-0089-0_10
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/bf03340164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014466678
244 https://doi.org/10.1007/bf03340164
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s10815-011-9544-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020995454
247 https://doi.org/10.1007/s10815-011-9544-6
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nature11396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029300076
250 https://doi.org/10.1038/nature11396
251 rdf:type schema:CreativeWork
252 grid-institutes:None schema:alternateName OVO Fertility Clinic, Montreal, Quebec, Canada
253 schema:name OVO Fertility Clinic, Montreal, Quebec, Canada
254 rdf:type schema:Organization
255 grid-institutes:grid.14709.3b schema:alternateName Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
256 Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada
257 schema:name Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
258 Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada
259 rdf:type schema:Organization
260 grid-institutes:grid.410559.c schema:alternateName Centre Hospitalier de l’Universite de Montreal, Montreal, Quebec, Canada
261 schema:name Centre Hospitalier de l’Universite de Montreal, Montreal, Quebec, Canada
262 OVO Fertility Clinic, Montreal, Quebec, Canada
263 rdf:type schema:Organization
264 grid-institutes:grid.416526.2 schema:alternateName St. Mary’s Hospital, 3830 Lacombe Ave., H3T 1M5, Montreal, Quebec, Canada
265 schema:name Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada
266 St. Mary’s Hospital, 3830 Lacombe Ave., H3T 1M5, Montreal, Quebec, Canada
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...