Sperm transcriptome profiling in oligozoospermia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Debbie Montjean, Pierre De La Grange, David Gentien, Audrey Rapinat, Stéphanie Belloc, Paul Cohen-Bacrie, Yves Menezo, Moncef Benkhalifa

ABSTRACT

PURPOSE: Investigate in what extent sperm transcriptome of infertile men is different from that of fertile individuals. METHODS: Semen samples were collected for determination of sperm parameters as well as for RNA isolation. Gene expression profile was investigated in spermatozoa of 8 infertile and 3 fertile men by microarray analysis using the Affymetrix Chip HG-U133 Plus 2.0. RESULT(S): We observed up to 33-fold reduction expression of genes involved in spermatogenesis and sperm motility. Furthermore, there is an important decrease in expression of genes involved in DNA repair as well as oxidative stress regulation. In this study, we also show a striking drop in expression of histone modification genes. CONCLUSION(S): We found that transcription profile in germ cells of men with idiopathic infertility is different from that of fertile individuals. Interestingly, about 15% of the regulated genes (Eddy Rev Reprod 4:23-30, 1999) play a role in spermatogenesis. More... »

PAGES

3-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10815-011-9644-3

DOI

http://dx.doi.org/10.1007/s10815-011-9644-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018633697

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21989496


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